ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0007188
Name adenylate cyclase-modulating G-protein coupled receptor signaling pathway
Type biological process
No. of Genes in ADHDgene  14
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 14)

Literature-origin genes (count: 9)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
ADRA1D adrenoceptor alpha 1D 20p13 1(0/1/0) TAS[10820200]
ADRB3 adrenoceptor beta 3 8p12 2(0/2/0) TAS[1718744]
ADRB2 adrenoceptor beta 2, surface 5q31-q32 2(1/1/0) TAS[2823249]
CNR1 cannabinoid receptor 1 (brain) 6q14-q15 1(1/0/0) IDA[18761332]
ADRA1B adrenoceptor alpha 1B 5q33.3 2(1/1/0) TAS[10820200]
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 16q13 1(0/1/0) IBA
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide 22q11.1-q11.2 1(0/1/0) IBA
MC4R melanocortin 4 receptor 18q22 1(0/1/0) TAS[8794897]
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 1p13 1(1/0/0) IBA

Genes from other sources Help (count: 5)

Approved Symbol Approved Name Source Evidence[PMID]
ADCY2 adenylate cyclase 2 (brain) Mapped by significant region ISS
PTGER4 prostaglandin E receptor 4 (subtype EP4) Mapped by significant region IDA[8163486]
ADORA2A adenosine A2a receptor Mapped by CNV TAS[10899090]
ADCY4 adenylate cyclase 4 Mapped by significant region ISS
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit Mapped by PBA pathway ISS