ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CNR1
Previous Symbol	CNR
Symbol Alias	CB1K5, CB-R, CB1, CANN6, CB1A
Approved Name	cannabinoid receptor 1 (brain)
Location	6q14-q15
Position	chr6:88849583-88875767, -
External Links	HGNC: 2159 Entrez Gene: 1268 Ensembl: ENSG00000118432 UCSC: uc003pmq.3
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Lu AT, 2008	haplotype CG P-value=0.008, significant association was detected with ADHD	Significant

Gene related SNPs (count: 15)

Literature-origin SNPs (count: 4)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs1049353	Chr6:88853635(Fwd)	3_prime_UTR_variant; downstream_gene_variant; synonymous_variant	1(0/1/0)
rs6454674	Chr6:88872930(Fwd)	intron_variant; upstream_gene_variant	1(0/1/0)
rs806377	Chr6:88858723(Fwd)	5_prime_UTR_variant; intron_variant; upstream_gene_variant	1(0/1/0)
rs806368	Chr6:88850100(Fwd)	3_prime_UTR_variant; downstream_gene_variant	1(0/1/0)

LD-proxies (count: 11)

rs_ID	Location	Functional Annotation
rs7766029	Chr6:88847435(Fwd)	downstream_gene_variant
rs4707436	Chr6:88851751(Fwd)	3_prime_UTR_variant; downstream_gene_variant
rs806381	Chr6:88865901(Fwd)	intron_variant
rs6454673	Chr6:88871049(Fwd)	intron_variant
rs806375	Chr6:88858521(Fwd)	5_prime_UTR_variant; intron_variant; upstream_gene_variant
rs806370	Chr6:88856331(Fwd)	intron_variant; upstream_gene_variant
rs806376	Chr6:88858648(Fwd)	5_prime_UTR_variant; intron_variant; upstream_gene_variant
rs806379	Chr6:88861267(Fwd)	intron_variant; upstream_gene_variant
rs806372	Chr6:88856563(Fwd)	intron_variant; upstream_gene_variant
rs806374	Chr6:88857320(Fwd)	intron_variant; upstream_gene_variant
rs806371	Chr6:88856363(Fwd)	intron_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 35)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 35)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0002866	positive regulation of acute inflammatory response to antigenic stimulus	Biological Process		1
GO:0004949	cannabinoid receptor activity	Molecular Function	IDA[18761332]	1
GO:0005886	plasma membrane	Cellular Component		772
GO:0008144	drug binding	Molecular Function		19
GO:0007613	memory	Biological Process		18
GO:0019233	sensory perception of pain	Biological Process		17
GO:0010976	positive regulation of neuron projection development	Biological Process		9
GO:0031999	negative regulation of fatty acid beta-oxidation	Biological Process		1
GO:0031622	positive regulation of fever generation	Biological Process		1
GO:0032496	response to lipopolysaccharide	Biological Process		22
GO:0032228	regulation of synaptic transmission, GABAergic	Biological Process		3
GO:0006950	response to stress	Biological Process		30
GO:0005887	integral to plasma membrane	Cellular Component	TAS[1718258]	220
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	Biological Process	IDA[18761332]	13
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	Biological Process	TAS[1718258]	18
GO:0007568	aging	Biological Process		29
GO:0007283	spermatogenesis	Biological Process		35
GO:0007610	behavior	Biological Process	TAS[1718258]	10
GO:0007584	response to nutrient	Biological Process		15
GO:0060259	regulation of feeding behavior	Biological Process		2
GO:0060405	regulation of penile erection	Biological Process		1
GO:0051966	regulation of synaptic transmission, glutamatergic	Biological Process		2
GO:0060135	maternal process involved in female pregnancy	Biological Process		5
GO:0050796	regulation of insulin secretion	Biological Process		22
GO:0051001	negative regulation of nitric-oxide synthase activity	Biological Process		2
GO:0045776	negative regulation of blood pressure	Biological Process		5
GO:0045777	positive regulation of blood pressure	Biological Process		6
GO:0045471	response to ethanol	Biological Process		17
GO:0045759	negative regulation of action potential	Biological Process		1
GO:0043065	positive regulation of apoptotic process	Biological Process		34
GO:0043278	response to morphine	Biological Process		9
GO:0035094	response to nicotine	Biological Process		6
GO:0042220	response to cocaine	Biological Process		11
GO:0033004	negative regulation of mast cell activation	Biological Process		1
GO:0033602	negative regulation of dopamine secretion	Biological Process		2

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93

Genes shared at least 5 GO terms with CNR1 (count: 13)

Gene Symbol	Pathway Count	Pathway List
DRD2	8	plasma membrane; drug binding; regulation of synaptic transmission, GABAergic; integral to plasma membrane; negative regulation of blood pressure; response to morphine; response to nicotine; response to cocaine;
DRD3	7	plasma membrane; drug binding; integral to plasma membrane; negative regulation of blood pressure; response to ethanol; response to morphine; response to cocaine;
HTR2A	7	plasma membrane; drug binding; memory; sensory perception of pain; response to stress; integral to plasma membrane; aging;
SLC6A3	7	plasma membrane; drug binding; integral to plasma membrane; aging; response to ethanol; response to nicotine; response to cocaine;
TACR3	7	plasma membrane; integral to plasma membrane; aging; regulation of feeding behavior; positive regulation of blood pressure; response to morphine; response to cocaine;
ADRB1	6	plasma membrane; drug binding; memory; sensory perception of pain; integral to plasma membrane; aging;
EDNRA	6	plasma membrane; sensory perception of pain; response to lipopolysaccharide; integral to plasma membrane; aging; response to morphine;
GRIN2A	6	plasma membrane; memory; sensory perception of pain; integral to plasma membrane; response to ethanol; positive regulation of apoptotic process;
HTR1B	6	plasma membrane; drug binding; integral to plasma membrane; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; response to ethanol; response to cocaine;
ADRB3	5	plasma membrane; integral to plasma membrane; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; aging;
OPRM1	5	plasma membrane; sensory perception of pain; integral to plasma membrane; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; behavior;
OXTR	5	plasma membrane; memory; integral to plasma membrane; positive regulation of blood pressure; response to cocaine;
SLC18A2	5	plasma membrane; drug binding; integral to plasma membrane; aging; response to cocaine;

Genes shared at least 2 KEGG pathways with CNR1 (count: 0)

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Region: chr6:88849583..88875767 View in gBrowse