ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Gene Report

Basic Info
Approved Symbol HTR1B
Symbol Alias S12, 5-HT1B, HTR1D2, 5-HT1DB
Approved Name 5-hydroxytryptamine (serotonin) receptor 1B
Location 6q13
Position chr6:78171922-78173181, -
External Links HGNC: 5287
Entrez Gene: 3351
Ensembl: ENSG00000135312
UCSC: uc003pil.1
No. of Studies 13 (significant: 5; non-significant: 8; trend: 0)
Source Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 13)
Reference Statistical Values/Author Comments Result of Statistical Analysis
Guimaraes AP, 2009 haplotype analyses: P-value=0.014. detected an over-transmission of -261G/-161T/861G haplotype in this gene. Significant
Gizer IR, 2009 The present study provides significant evidence suggesting an association between childhood ADHD and this gene. Significant
Carpentier, P. J., 2012 No significant association was found. Non-significant
Hawi Z, 2002 Significant preferential transmission of the allele 861G of the HTR1B was observed in the total sample Significant
Quist JF, 2003 TDT results for the HTR1B G861C polymorphism revealed a trend towards preferential transmission of the 861G allele and exhibited significantly greater paternal transmission of the G allele to the affected child; provided additional evidence that serotonin genes may be important risk factors for the development of ADHD Significant
Brookes K, 2006 UNPHASED TDT P-value=0.198, global P-value=0.928, WHAP TDT P_sum P-value=0.441, no SNP with nominal P-value<0.05 located in this gene Non-significant
Ickowicz A, 2007 Evidence for an association between the HTR1B gene and ADHD as a categorical diagnosis, or the inattentive and hyperactive-impulsive quantitative traits was not supported by either TDT single marker analysis or haplotype analysis. Non-significant
Heiser P, 2007 1 SNP showed no association to ADHD in their sample Non-significant
Ribases M, 2009(b) little evidence of association with ADHD was found. Non-significant
Li J, 2005 global test TRANSMIT P=0.068, X2=7.139, df=3, in ADHD-I trios, indicated a trend of association between haplotypes and ADHD-I; TRANSMIT P=0.054, X2=3.707, df=1 showed a tendency of excess transmission of 861G/ -161A haplotype; and a trend toward reduced transmission of 861C/-161A (X2=2.925, df=1, P=0.087) and 861C/-161T X2=2.739, df=1, P=0.098). Non-significant
Bobb AJ, 2005 no polymorphism was associated with ADHD Non-significant
Smoller JW, 2006 block 3, FBAT P-value=0.009, X2 (5df)=15.4, significant association with inattentive subtype; undertransmitted haplotype 3B-ACTTAT FBAT P-value=0.026, overtransmitted haplotype 3D-GGTCAT FBAT P-value=0.016 in inattentive Significant
Hawi Z, 2005 paternal versus maternal transmissions, 9 genes combined TDT P-value=0.0019, X2=9.6 (1df), OR=1.56; TDT P-value=0.0017, X2=9.8 when 5HT1B was removed in sensitivity analysis Non-significant

Gene related SNPs (count: 18)

Literature-origin SNPs (count: 9)

LD-proxies (count: 9)

Gene related CNVs (count: 0)

Gene related other variant (count: 2)

Gene related regions (count: 0)

Gene related GO terms (count: 22)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 22)

Gene related KEGG pathways (count: 1)

Genes shared at least 5 GO terms with HTR1B (count: 23)

Genes shared at least 2 KEGG pathways with HTR1B (count: 0)

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Region: chr6:78171922..78173181 View in gBrowse
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