ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

SNP Report

Basic Info
Name rs6296 dbSNP Ensembl
Location chr6:78172260(Fwd)
Variant Alleles C/G
Ancestral Allele C
Functional Annotation synonymous_variant.
Consequence to Transcript synonymous_variant(ENST00000369947)
No. of Studies 10 (significant: 3; non-significant: 7; trend: 0)
Source Literature-origin

SNP related studies (count: 10)
Reference Allele Change Risk Allele Statistical Values Author Comments Result of Statistical Analysis
Forero DA, 2009 C/G Not significant for the total samples. Not significant for the total samples. Non-significant
Gizer IR, 2009 Meta-analysis model: Fixed: OR=1.11, 95% CI=1.02-1.20, P-val...... Meta-analysis model: Fixed: OR=1.11, 95% CI=1.02-1.20, P-value=0.01; Q-statistic: P-value=0.441, I2=0 More... significant but modest association significant but modest association Significant
Heiser P, 2007 C/G allelic PDT P-value=0.91 allelic PDT P-value=0.91 showed no statistically significant preferential transmissio...... showed no statistically significant preferential transmission of any allele More... Non-significant
Ickowicz A, 2007 G/C C TDT P-value=0.47 TDT P-value=0.47 No evidence for biased transmission No evidence for biased transmission Non-significant
Ribases M, 2009(b) Case-control test: lowest P-value=0.033 for genotype analysi...... Case-control test: lowest P-value=0.033 for genotype analysis, P-value=0.52 for allele analysis in all childhood ADHD; lowest P-value=0.015 for genotype analysis, P-value=0.83 for allele analysis in childhood combined ADHD. More... no significance after correcting for multiple comparisons no significance after correcting for multiple comparisons Significant
Carpentier, P. J., 2012 G>C C genotypic P-value=0.69, adj OR=0.94, 95%CI=0.68-1.29; P-valu...... genotypic P-value=0.69, adj OR=0.94, 95%CI=0.68-1.29; P-value=0.54, adj OR=1.10, 95%CI=0.80-1.53 with gender as the covariate More... No significant association was found for the risk allele car...... No significant association was found for the risk allele carriers in the ADHD_all group compared to the control group. The covariate Gender had no significant effect. More... Non-significant
Smoller JW, 2006 G/C TDT P-value=0.12, X2=2.46, OR=1.24 in total sampl...... TDT P-value=0.12, X2=2.46, OR=1.24 in total sample; TDT P-value=0.013, X2=6.13, OR=1.69 among paternal transmission; TDT P-value=0.91, X2=0.012, OR=0.98 among maternal transmission in this study; TDT P-value=0.0009, X2=11, OR=1.35 in total sample; TDT P-value=0.00005, X2=16.5, OR=1.81 among paternal transmission; TDT P-value=0.22, X2=1.48, OR=1.19 among maternal transmission in combined data; allelic P-value=0.025 in inattentive, P-value=0.070 in ADHD, P-value=0.93 in combined More... evidence of significant overtransmission of the G allele in ...... evidence of significant overtransmission of the G allele in combined data, significant evidence of association with the G allele among paternal transmissions, but not among maternal transmissions in this study; displayed nominally significant association with the inattentive subtype More... Significant
Hawi Z, 2005 TDT P-value=0.11, X2=2.9, OR=1.6 for paternel tra...... TDT P-value=0.11, X2=2.9, OR=1.6 for paternel transmission; TDT P-value=0.46, X2=0.73, OR=1.3 for maternal transmission More... a trend was seen for paternal transmission and no significan...... a trend was seen for paternal transmission and no significant association was observed for maternal transmission More... Non-significant
Brookes K, 2006 C/G UNPHASED TDT P-value=0.456; WHAP TDT P-value=0.389 UNPHASED TDT P-value=0.456; WHAP TDT P-value=0.389 no significant association was observed no significant association was observed Non-significant
Bobb AJ, 2005 allelic TDT P-value=0.22, OR=1.06 in case-control analysis; ...... allelic TDT P-value=0.22, OR=1.06 in case-control analysis; allelic TDT P-value=0.49, RR=1.21 in family-based analysis More... non-significant association non-significant association Non-significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Genes from other sources Help (count: 0)


SNPs in LD with rs6296 (count: 14) View in gBrowse (chr6:78168373..78251686 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2>=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 14)