ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs6296 dbSNP Ensembl
Location	Chr6:78172260(Fwd)
Variant Alleles	C/G
Ancestral Allele	C
Functional Annotation	synonymous_variant.
Consequence to Transcript	synonymous_variant(ENST00000369947)
No. of Studies	10 (significant: 3; non-significant: 7; trend: 0)
Source	Literature-origin

SNP related studies (count: 10)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Bobb AJ, 2005			allelic TDT P-value=0.22, OR=1.06 in case-control analysis; ...... allelic TDT P-value=0.22, OR=1.06 in case-control analysis; allelic TDT P-value=0.49, RR=1.21 in family-based analysis More...	non-significant association non-significant association	Non-significant
Heiser P, 2007	C/G		allelic PDT P-value=0.91 allelic PDT P-value=0.91	showed no statistically significant preferential transmissio...... showed no statistically significant preferential transmission of any allele More...	Non-significant
Hawi Z, 2005			TDT P-value=0.11, X²=2.9, OR=1.6 for paternel tra...... TDT P-value=0.11, X²=2.9, OR=1.6 for paternel transmission; TDT P-value=0.46, X²=0.73, OR=1.3 for maternal transmission More...	a trend was seen for paternal transmission and no significan...... a trend was seen for paternal transmission and no significant association was observed for maternal transmission More...	Non-significant
Ribases M, 2009(b)			Case-control test: lowest P-value=0.033 for genotype analysi...... Case-control test: lowest P-value=0.033 for genotype analysis, P-value=0.52 for allele analysis in all childhood ADHD; lowest P-value=0.015 for genotype analysis, P-value=0.83 for allele analysis in childhood combined ADHD. More...	no significance after correcting for multiple comparisons no significance after correcting for multiple comparisons	Significant
Ickowicz A, 2007	G/C	C	TDT P-value=0.47 TDT P-value=0.47	No evidence for biased transmission No evidence for biased transmission	Non-significant
Forero DA, 2009	C/G			Not significant for the total samples. Not significant for the total samples.	Non-significant
Carpentier, P. J., 2012	G>C	C	genotypic P-value=0.69, adj OR=0.94, 95%CI=0.68-1.29; P-valu...... genotypic P-value=0.69, adj OR=0.94, 95%CI=0.68-1.29; P-value=0.54, adj OR=1.10, 95%CI=0.80-1.53 with gender as the covariate More...	No significant association was found for the risk allele car...... No significant association was found for the risk allele carriers in the ADHD_all group compared to the control group. The covariate Gender had no significant effect. More...	Non-significant
Smoller JW, 2006	G/C		TDT P-value=0.12, X²=2.46, OR=1.24 in total sampl...... TDT P-value=0.12, X²=2.46, OR=1.24 in total sample; TDT P-value=0.013, X²=6.13, OR=1.69 among paternal transmission; TDT P-value=0.91, X²=0.012, OR=0.98 among maternal transmission in this study; TDT P-value=0.0009, X²=11, OR=1.35 in total sample; TDT P-value=0.00005, X²=16.5, OR=1.81 among paternal transmission; TDT P-value=0.22, X²=1.48, OR=1.19 among maternal transmission in combined data; allelic P-value=0.025 in inattentive, P-value=0.070 in ADHD, P-value=0.93 in combined More...	evidence of significant overtransmission of the G allele in ...... evidence of significant overtransmission of the G allele in combined data, significant evidence of association with the G allele among paternal transmissions, but not among maternal transmissions in this study; displayed nominally significant association with the inattentive subtype More...	Significant
Gizer IR, 2009			Meta-analysis model: Fixed: OR=1.11, 95% CI=1.02-1.20, P-val...... Meta-analysis model: Fixed: OR=1.11, 95% CI=1.02-1.20, P-value=0.01; Q-statistic: P-value=0.441, I²=0 More...	significant but modest association significant but modest association	Significant
Brookes K, 2006	C/G		UNPHASED TDT P-value=0.456; WHAP TDT P-value=0.389 UNPHASED TDT P-value=0.456; WHAP TDT P-value=0.389	no significant association was observed no significant association was observed	Non-significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
HTR1B	5-hydroxytryptamine (serotonin) receptor 1B	6q13	13(5/8/0)

Genes from other sources (count: 0)

SNPs in LD with rs6296 (count: 16) View in gBrowse (chr6:78166945..78251686 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 2)

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs6298	synonymous_variant	4(0/4/0)	1.0[ASW]; 1.0[CEU]; 0.954[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 1.0[LWK]; 0.946[MEX]; 1.0[MKK]; 1.0[TSI]; 1.0[YRI]
rs2000292		2(1/1/0)	0.907[TSI]

LD-proxies (count: 14)

rs_ID	Functional Annotation	r²[population]
rs1458449		0.912[CEU]
rs1213355	nc_transcript_variant; non_coding_exon_variant	0.912[CEU]
rs13192352	downstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 1.0[YRI]
rs10806098	upstream_gene_variant	0.955[CEU]; 0.954[CHB]; 1.0[CHD]; 0.975[GIH]; 0.951[JPT]; 1.0[MEX]; 0.939[TSI]; 0.813[YRI]
rs12662392		0.912[CEU]; 0.907[CHB]; 0.904[JPT]
rs2798960		0.877[GIH]; 0.858[TSI]
rs4708347		0.912[CEU]; 0.863[CHD]; 0.877[GIH]; 0.86[JPT]; 0.946[MEX]; 0.884[TSI]
rs6916063	upstream_gene_variant	0.912[CEU]; 0.904[CHB]; 0.904[JPT]
rs10943465		0.912[CEU]; 0.842[CHD]; 0.877[GIH]; 0.86[JPT]; 0.946[MEX]; 0.884[TSI]
rs1419082		0.912[CEU]
rs1303712		1.0[CEU]
rs1778259	downstream_gene_variant	0.91[CEU]
rs1458443		0.912[CEU]
rs4142329	upstream_gene_variant	0.908[CEU]; 0.863[CHD]; 0.903[GIH]; 0.857[JPT]; 0.945[MEX]; 0.882[TSI]