ADHDgene Database

Gene Report

Basic Info

Approved Symbol	HTR1D
Previous Symbol	HTRL
Symbol Alias	RDC4, HT1DA, 5-HT1D
Approved Name	5-hydroxytryptamine (serotonin) receptor 1D
Location	1p36.3-p34.3
Position	chr1:23516993-23521222, -
External Links	HGNC: 5289 Entrez Gene: 3352 Ensembl: ENSG00000179546 UCSC: uc001bgn.2
No. of Studies	2 (significant: 1; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 2)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Ribases M, 2009(b)	little evidence of association with ADHD was found.	Non-significant
Li J, 2006(d)	A allele of the 1236A>G polymorphism exhibited both a trend toward preferential transmission to ADHD probands (X²=3.815, P-value=0.051) and a significant preferential transmission to probands of ADHD_C (X²=4.198, P-value=0.040)	Significant

Gene related SNPs (count: 7)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs604030	Chr1:23518227(Fwd)	downstream_gene_variant; intron_variant	1(1/0/0)
rs676643	Chr1:23521340(Fwd)	upstream_gene_variant	1(1/0/0)

rs_ID	Location	Functional Annotation
rs641032	Chr1:23513980(Fwd)	downstream_gene_variant
rs623988	Chr1:23519477(Fwd)	3_prime_UTR_variant; intron_variant
rs674386	Chr1:23521835(Fwd)	upstream_gene_variant
rs586589	Chr1:23523291(Fwd)	upstream_gene_variant
rs588387	Chr1:23523689(Fwd)	upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 2)

Variant Name	Variant Type	Location in Gene	No. of Studies (significant/non-significant/trend)
HTR1D_3'-UTR_1236A>G	point mutation	3' UTR	1 (1/0/0)
HTR1D_1350T>C	point mutation	coding region	1 (0/1/0)

Gene related regions (count: 0)

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005886	plasma membrane	Cellular Component		772
GO:0004993	serotonin receptor activity	Molecular Function		13
GO:0051378	serotonin binding	Molecular Function		7
GO:0014827	intestine smooth muscle contraction	Biological Process	IMP[9186750]	1
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	Biological Process	TAS[1565658]	18
GO:0005887	integral to plasma membrane	Cellular Component	TAS[1652050]	220
GO:0009636	response to toxin	Biological Process		15
GO:0007268	synaptic transmission	Biological Process	TAS[1565658]	96

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93

Genes shared at least 5 GO terms with HTR1D (count: 7)

Gene Symbol	Pathway Count	Pathway List
HTR1B	6	plasma membrane; serotonin receptor activity; serotonin binding; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; integral to plasma membrane; synaptic transmission;
HTR1E	6	plasma membrane; serotonin receptor activity; serotonin binding; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; integral to plasma membrane; synaptic transmission;
HTR1F	6	plasma membrane; serotonin receptor activity; serotonin binding; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; integral to plasma membrane; synaptic transmission;
HTR2A	5	plasma membrane; serotonin receptor activity; serotonin binding; integral to plasma membrane; synaptic transmission;
HTR3A	5	plasma membrane; serotonin receptor activity; serotonin binding; integral to plasma membrane; synaptic transmission;
HTR6	5	plasma membrane; serotonin receptor activity; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; integral to plasma membrane; synaptic transmission;
HTR7	5	plasma membrane; serotonin receptor activity; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; integral to plasma membrane; synaptic transmission;

Genes shared at least 2 KEGG pathways with HTR1D (count: 0)

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Region: chr1:23516993..23521222 View in gBrowse