ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HTR1E
Symbol Alias	5-HT1E
Approved Name	5-hydroxytryptamine (serotonin) receptor 1E
Location	6q14-q15
Position	chr6:87647024-87726401, +
External Links	HGNC: 5291 Entrez Gene: 3354 Ensembl: ENSG00000168830 UCSC: uc003pli.2
No. of Studies	2 (significant: 2; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 2)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Brookes K, 2006	UNPHASED TDT P-value=0.0513, global P-value=0.509, WHAP TDT P_sum P-value=0.108; OR=1.42, one or more SNPs with nominal P-value<0.05 located in this gene	Significant
Oades RD, 2008	1 SNP showed significant association	Significant

Gene related SNPs (count: 12)

Literature-origin SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs7751022	Chr6:87684800(Fwd)	downstream_gene_variant; intron_variant	1(1/0/0)
rs1406946	Chr6:87647591(Fwd)	intron_variant	1(1/0/0)

LD-proxies (count: 10)

rs_ID	Location	Functional Annotation
rs4707340	Chr6:87720685(Fwd)	intron_variant
rs11961440	Chr6:87667226(Fwd)	intron_variant
rs11966308	Chr6:87700820(Fwd)	intron_variant
rs718166	Chr6:87693623(Fwd)	intron_variant
rs4707335	Chr6:87666120(Fwd)	intron_variant
rs722763	Chr6:87692655(Fwd)	intron_variant
rs6914350	Chr6:87693076(Fwd)	intron_variant
rs11962946	Chr6:87690343(Fwd)	intron_variant
rs11963002	Chr6:87690518(Fwd)	intron_variant
rs7751001	Chr6:87684753(Fwd)	downstream_gene_variant; intron_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 9)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007210	serotonin receptor signaling pathway	Biological Process	IDA[1608964]	9
GO:0007268	synaptic transmission	Biological Process	TAS[1608964]	96
GO:0051378	serotonin binding	Molecular Function	IDA[1608964]	7
GO:0005886	plasma membrane	Cellular Component		772
GO:0005887	integral to plasma membrane	Cellular Component	TAS[1733778]	220
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process	TAS[1608964]	72
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	Biological Process	TAS[1733778]	18
GO:0004993	serotonin receptor activity	Molecular Function	IDA[1608964]	13
GO:0004930	G-protein coupled receptor activity	Molecular Function	TAS[1733778]	236

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93

Genes shared at least 5 GO terms with HTR1E (count: 13)

Gene Symbol	Pathway Count	Pathway List
HTR1F	7	serotonin receptor signaling pathway; synaptic transmission; serotonin binding; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; serotonin receptor activity;
HTR1B	7	synaptic transmission; serotonin binding; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; serotonin receptor activity;
HTR2A	6	serotonin receptor signaling pathway; synaptic transmission; serotonin binding; plasma membrane; integral to plasma membrane; serotonin receptor activity;
HTR3A	6	serotonin receptor signaling pathway; synaptic transmission; serotonin binding; plasma membrane; integral to plasma membrane; serotonin receptor activity;
HTR4	6	serotonin receptor signaling pathway; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; serotonin receptor activity;
HTR5A	6	serotonin receptor signaling pathway; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; serotonin receptor activity;
HTR7	6	serotonin receptor signaling pathway; synaptic transmission; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; serotonin receptor activity;
HTR1D	6	synaptic transmission; serotonin binding; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; serotonin receptor activity;
HTR1A	5	serotonin receptor signaling pathway; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway; serotonin receptor activity;
HTR2C	5	serotonin receptor signaling pathway; synaptic transmission; serotonin binding; plasma membrane; serotonin receptor activity;
GRM1	5	synaptic transmission; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway; G-protein coupled receptor activity;
HTR6	5	synaptic transmission; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; serotonin receptor activity;
MTNR1B	5	synaptic transmission; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; G-protein coupled receptor activity;

Genes shared at least 2 KEGG pathways with HTR1E (count: 0)

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Region: chr6:87647024..87726401 View in gBrowse