ADHDgene Database

Gene Report

Basic Info

Approved Symbol	HTR1A
Previous Symbol	ADRB2RL1, ADRBRL1
Symbol Alias	5-HT1A
Approved Name	5-hydroxytryptamine (serotonin) receptor 1A
Location	5q11.2-q13
Position	chr5:63256183-63258334, -
External Links	HGNC: 5286 Entrez Gene: 3350 Ensembl: ENSG00000178394 UCSC: uc011cqt.1
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Shim SH, 2010	genotype 'CC' of HTR1A C-1019G is associated with a higher risk of ADHD	Significant

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs6295	Chr5:63258565(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant	1(1/0/0)

Gene related CNVs (count: 0)

Gene related other variant (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (significant/non-significant/trend)
HTR1A_C-1019G	point mutation		1 (1/0/0)

Gene related regions (count: 0)

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0008284	positive regulation of cell proliferation	Biological Process	TAS[1330092]	69
GO:0007610	behavior	Biological Process	TAS[9736659]	10
GO:0007210	serotonin receptor signaling pathway	Biological Process	TAS[9736659]	9
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process	TAS[1330092]	72
GO:0005887	integral to plasma membrane	Cellular Component	TAS[3138543]	220
GO:0005886	plasma membrane	Cellular Component		772
GO:0004993	serotonin receptor activity	Molecular Function		13

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93

Genes shared at least 5 GO terms with HTR1A (count: 4)

Gene Symbol	Pathway Count	Pathway List
HTR4	6	positive regulation of cell proliferation; serotonin receptor signaling pathway; G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; serotonin receptor activity;
HTR2A	5	positive regulation of cell proliferation; serotonin receptor signaling pathway; integral to plasma membrane; plasma membrane; serotonin receptor activity;
HTR1E	5	serotonin receptor signaling pathway; G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; serotonin receptor activity;
HTR5A	5	serotonin receptor signaling pathway; G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; serotonin receptor activity;

Genes shared at least 2 KEGG pathways with HTR1A (count: 0)

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Region: chr5:63256183..63258334 View in gBrowse