ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HTR1F
Symbol Alias	HTR1EL, 5-HT1F
Approved Name	5-hydroxytryptamine (serotonin) receptor 1F
Location	3p12
Position	chr3:88031726-88042919, +
External Links	HGNC: 5292 Entrez Gene: 3355 Ensembl: ENSG00000179097 UCSC: uc003dqr.2
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Ribases M, 2009(b)	little evidence of association with ADHD was found.	Non-significant

Gene related SNPs (count: 8)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs1503433	Chr3:88037200(Fwd)	upstream_gene_variant	1(1/0/0)

LD-proxies (count: 7)

rs_ID	Location	Functional Annotation
rs9863076	Chr3:88033939(Fwd)
rs2099229	Chr3:88029064(Fwd)
rs6770013	Chr3:88031698(Fwd)
rs7630716	Chr3:88033471(Fwd)
rs12714696	Chr3:88032327(Fwd)
rs2016224	Chr3:88041650(Fwd)	3_prime_UTR_variant
rs7629565	Chr3:88044780(Fwd)	downstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 7)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004993	serotonin receptor activity	Molecular Function	IDA[8380639]	13
GO:0007268	synaptic transmission	Biological Process	TAS[8380639]	96
GO:0051378	serotonin binding	Molecular Function	IDA[8380639]	7
GO:0005886	plasma membrane	Cellular Component		772
GO:0005887	integral to plasma membrane	Cellular Component	TAS[8380639]	220
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	Biological Process	TAS[8380639]	18
GO:0007210	serotonin receptor signaling pathway	Biological Process	IDA[8380639]	9

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93

Genes shared at least 5 GO terms with HTR1F (count: 10)

Gene Symbol	Pathway Count	Pathway List
HTR1E	7	serotonin receptor activity; synaptic transmission; serotonin binding; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; serotonin receptor signaling pathway;
HTR1B	6	serotonin receptor activity; synaptic transmission; serotonin binding; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;
HTR1D	6	serotonin receptor activity; synaptic transmission; serotonin binding; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;
HTR2A	6	serotonin receptor activity; synaptic transmission; serotonin binding; plasma membrane; integral to plasma membrane; serotonin receptor signaling pathway;
HTR3A	6	serotonin receptor activity; synaptic transmission; serotonin binding; plasma membrane; integral to plasma membrane; serotonin receptor signaling pathway;
HTR7	6	serotonin receptor activity; synaptic transmission; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; serotonin receptor signaling pathway;
HTR2C	5	serotonin receptor activity; synaptic transmission; serotonin binding; plasma membrane; serotonin receptor signaling pathway;
HTR4	5	serotonin receptor activity; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; serotonin receptor signaling pathway;
HTR5A	5	serotonin receptor activity; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; serotonin receptor signaling pathway;
HTR6	5	serotonin receptor activity; synaptic transmission; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;

Genes shared at least 2 KEGG pathways with HTR1F (count: 0)

View in gBrowse

Region: chr3:88031726..88042919 View in gBrowse