ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HTR7
Symbol Alias	5-HT7
Approved Name	5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
Location	10q21-q24
Position	chr10:92500575-92617671, -
External Links	HGNC: 5302 Entrez Gene: 3363 Ensembl: ENSG00000148680 UCSC: uc001kha.2
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Ribases M, 2009(b)	little evidence of association with ADHD was found.	Non-significant

Gene related SNPs (count: 25)

Literature-origin SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs11817364	Chr10:92498026(Fwd)	downstream_gene_variant	1(1/0/0)
rs12259062	Chr10:92610045(Fwd)	intron_variant	1(1/0/0)
rs11186320	Chr10:92576448(Fwd)	intron_variant	1(1/0/0)

LD-proxies (count: 22)

rs_ID	Location	Functional Annotation
rs11812708	Chr10:92505265(Fwd)	intron_variant
rs4520504	Chr10:92602373(Fwd)	intron_variant
rs11599902	Chr10:92598823(Fwd)	intron_variant
rs12254390	Chr10:92620148(Fwd)	upstream_gene_variant
rs7072526	Chr10:92529270(Fwd)	intron_variant
rs7912164	Chr10:92519954(Fwd)	intron_variant
rs1935351	Chr10:92565725(Fwd)	intron_variant
rs4933195	Chr10:92574239(Fwd)	intron_variant
rs12766851	Chr10:92562831(Fwd)	intron_variant
rs11594548	Chr10:92564191(Fwd)	intron_variant
rs12783703	Chr10:92560413(Fwd)	intron_variant
rs11186309	Chr10:92561557(Fwd)	intron_variant
rs12412496	Chr10:92546165(Fwd)	intron_variant
rs4272713	Chr10:92549972(Fwd)	intron_variant
rs7091039	Chr10:92534755(Fwd)	intron_variant
rs4933607	Chr10:92545069(Fwd)	intron_variant
rs7087400	Chr10:92587180(Fwd)	intron_variant
rs7086484	Chr10:92533729(Fwd)	intron_variant
rs10881838	Chr10:92590233(Fwd)	intron_variant
rs10785972	Chr10:92593800(Fwd)	intron_variant
rs12259401	Chr10:92594121(Fwd)	intron_variant
rs11597471	Chr10:92598767(Fwd)	intron_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 8)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007268	synaptic transmission	Biological Process	TAS[8226867]	96
GO:0007210	serotonin receptor signaling pathway	Biological Process	TAS[8226867]	9
GO:0008015	blood circulation	Biological Process	TAS[8226867]	12
GO:0007623	circadian rhythm	Biological Process	TAS[8398139]	15
GO:0005886	plasma membrane	Cellular Component		772
GO:0004993	serotonin receptor activity	Molecular Function		13
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	Biological Process	TAS[8226867]	18
GO:0005887	integral to plasma membrane	Cellular Component	TAS[8226867]	220

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04020	Calcium signaling pathway	63	Ca2+ that enters the cell from the outside is a principal so...... Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs). More...

Genes shared at least 5 GO terms with HTR7 (count: 9)

Gene Symbol	Pathway Count	Pathway List
HTR1E	6	synaptic transmission; serotonin receptor signaling pathway; plasma membrane; serotonin receptor activity; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; integral to plasma membrane;
HTR1F	6	synaptic transmission; serotonin receptor signaling pathway; plasma membrane; serotonin receptor activity; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; integral to plasma membrane;
HTR1B	5	synaptic transmission; plasma membrane; serotonin receptor activity; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; integral to plasma membrane;
HTR1D	5	synaptic transmission; plasma membrane; serotonin receptor activity; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; integral to plasma membrane;
HTR2A	5	synaptic transmission; serotonin receptor signaling pathway; plasma membrane; serotonin receptor activity; integral to plasma membrane;
HTR3A	5	synaptic transmission; serotonin receptor signaling pathway; plasma membrane; serotonin receptor activity; integral to plasma membrane;
HTR6	5	synaptic transmission; plasma membrane; serotonin receptor activity; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; integral to plasma membrane;
HTR4	5	serotonin receptor signaling pathway; plasma membrane; serotonin receptor activity; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; integral to plasma membrane;
HTR5A	5	serotonin receptor signaling pathway; plasma membrane; serotonin receptor activity; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; integral to plasma membrane;

Genes shared at least 2 KEGG pathways with HTR7 (count: 30)

Gene Symbol	Pathway Count	Pathway List
ADORA2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1B	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1D	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
BDKRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKAR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKBR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRNA7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
EDNRA	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRIN2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2C	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR4	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR5A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
LTB4R2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
OXTR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
TACR3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;

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Region: chr10:92500575..92617671 View in gBrowse