ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TACR3
Symbol Alias	NK3R
Approved Name	tachykinin receptor 3
Name Alias	neurokinin beta receptor
Location	4q25
Position	chr4:104507188-104640973, -
External Links	HGNC: 11528 Entrez Gene: 6870 Ensembl: ENSG00000169836 UCSC: uc003hxe.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2010]_40	chr4:104848417-104972885 (NCBI Build 35 (hg17))	124469	4q24	Duplication	Maternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007217	tachykinin receptor signaling pathway	Biological Process	TAS[8990205]	2
GO:0007568	aging	Biological Process		29
GO:0010460	positive regulation of heart rate	Biological Process		4
GO:0032355	response to estradiol stimulus	Biological Process		18
GO:0004995	tachykinin receptor activity	Molecular Function		1
GO:0005634	nucleus	Cellular Component		770
GO:0005886	plasma membrane	Cellular Component		772
GO:0005887	integral to plasma membrane	Cellular Component	TAS[1374246]	220
GO:0045777	positive regulation of blood pressure	Biological Process		6
GO:0060259	regulation of feeding behavior	Biological Process		2
GO:0070474	positive regulation of uterine smooth muscle contraction	Biological Process		3
GO:0042053	regulation of dopamine metabolic process	Biological Process		5
GO:0042220	response to cocaine	Biological Process		11
GO:0042538	hyperosmotic salinity response	Biological Process		2
GO:0043278	response to morphine	Biological Process		9

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04020	Calcium signaling pathway	63	Ca2+ that enters the cell from the outside is a principal so...... Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs). More...

Genes shared at least 5 GO terms with TACR3 (count: 4)

Gene Symbol	Pathway Count	Pathway List
CNR1	7	aging; plasma membrane; integral to plasma membrane; positive regulation of blood pressure; regulation of feeding behavior; response to cocaine; response to morphine;
OXTR	6	response to estradiol stimulus; plasma membrane; integral to plasma membrane; positive regulation of blood pressure; positive regulation of uterine smooth muscle contraction; response to cocaine;
SLC6A3	5	aging; plasma membrane; integral to plasma membrane; regulation of dopamine metabolic process; response to cocaine;
GHR	5	response to estradiol stimulus; nucleus; plasma membrane; integral to plasma membrane; response to morphine;

Genes shared at least 2 KEGG pathways with TACR3 (count: 30)

Gene Symbol	Pathway Count	Pathway List
ADORA2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1B	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1D	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
BDKRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKAR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKBR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRNA7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
EDNRA	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRIN2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2C	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR4	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR5A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
LTB4R2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
OXTR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;

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Region: chr4:104507188..104640973 View in gBrowse