ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

KEGG Pathway Report

Basic Info
ID hsa04020
Name Calcium signaling pathway
No. of Genes in ADHDgene  66
Source Pathway by Database Search

Pathway related genes in ADHDgene (count: 66)

Literature-origin genes (count: 23)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 15q13.3 2(0/1/1)
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 10q21-q24 1(0/1/0)
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 5q31-q33 1(1/0/0)
OXTR oxytocin receptor 3p25 1(0/1/0)
ADRB1 adrenoceptor beta 1 10q25.3 2(0/2/0)
ADRB3 adrenoceptor beta 3 8p12 2(0/2/0)
DRD1 dopamine receptor D1 5q34-q35 8(5/3/0)
GRM5 glutamate receptor, metabotropic 5 11q14.3 2(1/0/1)
NOS1 nitric oxide synthase 1 (neuronal) 12q24.22 1(1/0/0)
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 7q36.1 1(0/1/0)
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 12p13.3 3(0/3/0)
GRM1 glutamate receptor, metabotropic 1 6q24 1(1/0/0)
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 1p36-p35 2(0/2/0)
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 13q14-q21 13(7/6/0)
DRD5 dopamine receptor D5 4p16.1 22(14/6/2)
ADRA1B adrenoceptor alpha 1B 5q33.3 2(1/1/0)
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 18p11.22-p11.21 1(1/0/0)
ADRA1A adrenoceptor alpha 1A 8p21.2 3(2/1/0)
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 16p13.2 4(1/3/0)
ADRA1D adrenoceptor alpha 1D 20p13 1(0/1/0)
ADRB2 adrenoceptor beta 2, surface 5q31-q32 2(1/1/0)
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Xq23 5(2/3/0)
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 Xq28 1(0/1/0)

Genes from other sources Help(count: 43)

Approved Symbol Approved Name Location Source
CAMK2D calcium/calmodulin-dependent protein kinase II delta 4q26 Mapped by CNV
ADORA2A adenosine A2a receptor 22q11.23 Mapped by CNV
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 3p26.1 Mapped by CNV
ERBB2 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 17q11.2-q12 Mapped by LD-proxy
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 16p12.1 Mapped by Literature SNP
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 11q13 Mapped by significant region
PLN phospholamban 6q22.1 Mapped by significant region
RYR2 ryanodine receptor 2 (cardiac) 1q43 Mapped by CNV; Mapped by PBA pathway
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 19p13 Mapped by PBA pathway
RYR3 ryanodine receptor 3 15q14-q15 Mapped by CNV; Mapped by PBA pathway
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit 22q13.1 Mapped by CNV
PHKG2 phosphorylase kinase, gamma 2 (testis) 16p11.2 Mapped by CNV
ADCY4 adenylate cyclase 4 14q11.2 Mapped by significant region
ADCY2 adenylate cyclase 2 (brain) 5p15.3 Mapped by significant region
ADCY3 adenylate cyclase 3 2p23.3 Mapped by LD-proxy
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 16q24.1 Mapped by significant region
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 9q34 Mapped by PBA pathway
TACR3 tachykinin receptor 3 4q25 Mapped by CNV
CHRM1 cholinergic receptor, muscarinic 1 11q12-q13 Mapped by significant region; Mapped by PBA pathway
PLCD1 phospholipase C, delta 1 3p22-p21.3 Mapped by PBA pathway
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 16p13.3 Mapped by significant region; Mapped by PBA pathway
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit 17q22 Mapped by PBA pathway
CHRM3 cholinergic receptor, muscarinic 3 1q43 Mapped by CNV; Mapped by PBA pathway
LTB4R2 leukotriene B4 receptor 2 14q11.2-q12 Mapped by significant region
PLCD4 phospholipase C, delta 4 2q35 Mapped by significant region
CHRM5 cholinergic receptor, muscarinic 5 15q26 Mapped by CNV; Mapped by PBA pathway
P2RX3 purinergic receptor P2X, ligand-gated ion channel, 3 11q12 Mapped by significant region
P2RX6 purinergic receptor P2X, ligand-gated ion channel, 6 22q11.21 Mapped by CNV
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 3p14.3 Mapped by PBA pathway
TRPC1 transient receptor potential cation channel, subfamily C, member 1 3q23 Mapped by PBA pathway
CCKAR cholecystokinin A receptor 4p15.2 Mapped by CNV
RYR1 ryanodine receptor 1 (skeletal) 19q13.1 Mapped by PBA pathway
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 12p11.23 Mapped by Literature SNP
CCKBR cholecystokinin B receptor 11p15.4 Mapped by CNV; Mapped by PBA pathway
PLCE1 phospholipase C, epsilon 1 10q23 Mapped by PBA pathway
PLCB2 phospholipase C, beta 2 15q15.1 Mapped by PBA pathway
PPP3R2 protein phosphatase 3, regulatory subunit B, beta 9q31 Mapped by significant region
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit Xp11.23 Mapped by Literature SNP; Mapped by PBA pathway
EDNRA endothelin receptor type A 4q31.22 Mapped by PBA pathway
BDKRB2 bradykinin receptor B2 14q32.1-q32.2 Mapped by PBA pathway
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 1q32 Mapped by PBA pathway
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 1q25.3 Mapped by significant region; Mapped by PBA pathway
ADCY9 adenylate cyclase 9 16p13.3 Mapped by significant region