ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CCKBR
Approved Name	cholecystokinin B receptor
Location	11p15.4
Position	chr11:6280966-6293357, 1
External Links	HGNC: 1571 Entrez Gene: 887 Ensembl: ENSG00000110148 UCSC: uc001mcp.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_29	chr11:5582423-7488751 (NCBI Build 36.1 (hg18))	1859865	11p15.4	Loss	De novo

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0015054	gastrin receptor activity	molecular function	IDA[10913157]	1
GO:0031741	type B gastrin/cholecystokinin receptor binding	molecular function	IDA[8185642]	1
GO:0005887	integral to plasma membrane	cellular component	IC[10913157]	236
GO:0004951	cholecystokinin receptor activity	molecular function	TAS[7681836]	2
GO:0008283	cell proliferation	biological process	TAS[10400698]	66
GO:0007586	digestion	biological process	TAS[7681836]	13
GO:0008284	positive regulation of cell proliferation	biological process	IDA[10913157]	75
GO:0007600	sensory perception	biological process	TAS[7681836]	5
GO:0007166	cell surface receptor signaling pathway	biological process	NAS[10913157]	36
GO:0004435	phosphatidylinositol phospholipase C activity	molecular function	TAS[7681836]	20
GO:0005886	plasma membrane	cellular component	TAS	839
GO:0007204	elevation of cytosolic calcium ion concentration	biological process	IDA[10913157]	21
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	molecular function	TAS[10400698]	1
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	biological process	TAS[8455720]	13
GO:0007631	feeding behavior	biological process	TAS[7681836]	10

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	89
hsa04020	Calcium signaling pathway	66

Genes shared at least 5 GO terms with CCKBR (count: 10)

Gene Symbol	Pathway Count	Pathway List
CCKAR	7	integral to plasma membrane; cholecystokinin receptor activity; digestion; plasma membrane; elevation of cytosolic calcium ion concentration; phospholipase C-activating G-protein coupled receptor signaling pathway; feeding behavior;
CXCR2	6	integral to plasma membrane; positive regulation of cell proliferation; cell surface receptor signaling pathway; plasma membrane; elevation of cytosolic calcium ion concentration; phospholipase C-activating G-protein coupled receptor signaling pathway;
EDNRA	6	integral to plasma membrane; cell proliferation; positive regulation of cell proliferation; phosphatidylinositol phospholipase C activity; plasma membrane; elevation of cytosolic calcium ion concentration;
BDKRB2	5	integral to plasma membrane; cell surface receptor signaling pathway; phosphatidylinositol phospholipase C activity; plasma membrane; elevation of cytosolic calcium ion concentration;
CHRM3	5	integral to plasma membrane; cell proliferation; digestion; phosphatidylinositol phospholipase C activity; plasma membrane;
CHRM1	5	integral to plasma membrane; cell proliferation; positive regulation of cell proliferation; phosphatidylinositol phospholipase C activity; plasma membrane;
CCR5	5	integral to plasma membrane; cell surface receptor signaling pathway; phosphatidylinositol phospholipase C activity; plasma membrane; elevation of cytosolic calcium ion concentration;
NTSR2	5	integral to plasma membrane; sensory perception; cell surface receptor signaling pathway; plasma membrane; phospholipase C-activating G-protein coupled receptor signaling pathway;
OPRM1	5	integral to plasma membrane; sensory perception; plasma membrane; elevation of cytosolic calcium ion concentration; phospholipase C-activating G-protein coupled receptor signaling pathway;
PLCE1	5	cell proliferation; phosphatidylinositol phospholipase C activity; plasma membrane; elevation of cytosolic calcium ion concentration; phospholipase C-activating G-protein coupled receptor signaling pathway;

Genes shared at least 2 KEGG pathways with CCKBR (count: 28)

Gene Symbol	Pathway Count	Pathway List
TACR3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2C	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRIN2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
BDKRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR4	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
EDNRA	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR5A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
LTB4R2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADORA2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1B	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
OXTR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKAR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;

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Region: chr11:6280966..6293357 View in gBrowse