ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PLCE1
Symbol Alias	KIAA1516, PLCE, NPHS3
Approved Name	phospholipase C, epsilon 1
Name Alias	nephrosis type 3
Location	10q23
Position	chr10:95753746-96088149, +
External Links	HGNC: 17175 Entrez Gene: 51196 Ensembl: ENSG00000138193 UCSC: uc001kjk.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 33)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016298	lipase activity	Molecular Function		49

GO terms by database search (count: 32)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006644	phospholipid metabolic process	Biological Process	IC[11022048]	59
GO:0006651	diacylglycerol biosynthetic process	Biological Process	TAS[11022047]	2
GO:0006940	regulation of smooth muscle contraction	Biological Process	TAS[11022047]	5
GO:0007010	cytoskeleton organization	Biological Process	NAS[11022047]	12
GO:0005515	protein binding	Molecular Function	IPI[11022048]	910
GO:0005737	cytoplasm	Cellular Component		690
GO:0005829	cytosol	Cellular Component	IDA[11022048]	447
GO:0005886	plasma membrane	Cellular Component	IDA[11022048]	772
GO:0007265	Ras protein signal transduction	Biological Process	TAS[11022048]	15
GO:0007507	heart development	Biological Process	TAS[11022047]	23
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	Biological Process	IDA[11022047]	5
GO:0008283	cell proliferation	Biological Process	NAS[11022048]	60
GO:0007173	epidermal growth factor receptor signaling pathway	Biological Process	NAS[11022048]	25
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	Biological Process	IDA[11022047]	12
GO:0007204	elevation of cytosolic calcium ion concentration	Biological Process	TAS[11022047]	20
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	Biological Process	NAS[11022048]	8
GO:0032835	glomerulus development	Biological Process	IMP[17086182]	2
GO:0019899	enzyme binding	Molecular Function	IPI[11022048]	47
GO:0046578	regulation of Ras protein signal transduction	Biological Process	IDA[11022047]	3
GO:0045859	regulation of protein kinase activity	Biological Process	IDA[11022047]	2
GO:0016042	lipid catabolic process	Biological Process		32
GO:0019722	calcium-mediated signaling	Biological Process	NAS[11022048]; TAS[11022047]	7
GO:0017016	Ras GTPase binding	Molecular Function	TAS[11022048]	2
GO:0048016	inositol phosphate-mediated signaling	Biological Process	TAS[11022047]	2
GO:0005509	calcium ion binding	Molecular Function		124
GO:0005085	guanyl-nucleotide exchange factor activity	Molecular Function	TAS[11022047]	17
GO:0005057	receptor signaling protein activity	Molecular Function	TAS[11022048]	9
GO:0004629	phospholipase C activity	Molecular Function	IDA[11022047]	6
GO:0004435	phosphatidylinositol phospholipase C activity	Molecular Function	IDA[11022047]	20
GO:0001558	regulation of cell growth	Biological Process	TAS[11022047]	11
GO:0000187	activation of MAPK activity	Biological Process	IDA[11022047]	21
GO:0000139	Golgi membrane	Cellular Component		95

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00562	Inositol phosphate metabolism	14
hsa04070	Phosphatidylinositol signaling system	19
hsa04020	Calcium signaling pathway	63	Ca2+ that enters the cell from the outside is a principal so...... Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs). More...

Genes shared at least 5 GO terms with PLCE1 (count: 37)

Gene Symbol	Pathway Count	Pathway List
PLCB2	7	phospholipid metabolic process; cytosol; lipase activity; lipid catabolic process; calcium ion binding; phospholipase C activity; phosphatidylinositol phospholipase C activity;
PLCD1	7	phospholipid metabolic process; cytoplasm; cytosol; lipase activity; lipid catabolic process; calcium ion binding; phosphatidylinositol phospholipase C activity;
BCAR1	7	protein binding; cytoplasm; cytosol; plasma membrane; cell proliferation; epidermal growth factor receptor signaling pathway; regulation of cell growth;
CCR5	7	protein binding; cytoplasm; plasma membrane; elevation of cytosolic calcium ion concentration; lipase activity; calcium-mediated signaling; phosphatidylinositol phospholipase C activity;
EDNRA	7	plasma membrane; heart development; cell proliferation; elevation of cytosolic calcium ion concentration; protein kinase C-activating G-protein coupled receptor signaling pathway; lipase activity; phosphatidylinositol phospholipase C activity;
PIK3CG	6	phospholipid metabolic process; protein binding; cytoplasm; cytosol; plasma membrane; elevation of cytosolic calcium ion concentration;
PLA2G6	6	phospholipid metabolic process; cytoplasm; cytosol; elevation of cytosolic calcium ion concentration; lipase activity; lipid catabolic process;
PLD2	6	phospholipid metabolic process; cytoskeleton organization; protein binding; plasma membrane; lipase activity; lipid catabolic process;
PRKD1	6	phospholipid metabolic process; protein binding; cytoplasm; cytosol; plasma membrane; cell proliferation;
SNCA	6	phospholipid metabolic process; protein binding; cytoplasm; cytosol; plasma membrane; calcium ion binding;
ADRBK1	6	protein binding; cytoplasm; cytosol; plasma membrane; heart development; epidermal growth factor receptor signaling pathway;
CBL	6	protein binding; cytoplasm; cytosol; plasma membrane; epidermal growth factor receptor signaling pathway; calcium ion binding;
MAPK1	6	protein binding; cytoplasm; cytosol; Ras protein signal transduction; epidermal growth factor receptor signaling pathway; activation of MAPK activity;
PLCG2	6	protein binding; cytosol; plasma membrane; calcium-mediated signaling; phospholipase C activity; phosphatidylinositol phospholipase C activity;
PLCH1	6	cytoplasm; cytosol; lipase activity; lipid catabolic process; calcium ion binding; phosphatidylinositol phospholipase C activity;
RASGRP2	6	cytosol; plasma membrane; Ras protein signal transduction; calcium ion binding; guanyl-nucleotide exchange factor activity; regulation of cell growth;
CCKBR	6	plasma membrane; cell proliferation; phospholipase C-activating G-protein coupled receptor signaling pathway; elevation of cytosolic calcium ion concentration; lipase activity; phosphatidylinositol phospholipase C activity;
INPPL1	5	phospholipid metabolic process; protein binding; cytoplasm; cytosol; plasma membrane;
PIK3R1	5	phospholipid metabolic process; protein binding; cytosol; plasma membrane; epidermal growth factor receptor signaling pathway;
PLA2G3	5	phospholipid metabolic process; plasma membrane; lipase activity; lipid catabolic process; calcium ion binding;
PLA2G4B	5	phospholipid metabolic process; cytosol; lipase activity; calcium-mediated signaling; calcium ion binding;
PLA2G5	5	phospholipid metabolic process; plasma membrane; lipase activity; lipid catabolic process; calcium ion binding;
PLD1	5	phospholipid metabolic process; Ras protein signal transduction; lipase activity; lipid catabolic process; Golgi membrane;
ARRB1	5	protein binding; cytoplasm; cytosol; plasma membrane; Golgi membrane;
BDKRB2	5	protein binding; plasma membrane; elevation of cytosolic calcium ion concentration; lipase activity; phosphatidylinositol phospholipase C activity;
DAXX	5	protein binding; cytoplasm; cytosol; enzyme binding; receptor signaling protein activity;
EIF2B1	5	protein binding; cytoplasm; cytosol; plasma membrane; guanyl-nucleotide exchange factor activity;
ERBB2	5	protein binding; plasma membrane; heart development; cell proliferation; epidermal growth factor receptor signaling pathway;
GOLPH3	5	protein binding; cytoplasm; cytosol; plasma membrane; cell proliferation;
GSK3B	5	protein binding; cytoplasm; cytosol; plasma membrane; epidermal growth factor receptor signaling pathway;
ILK	5	protein binding; cytoplasm; cytosol; plasma membrane; cell proliferation;
MAPK3	5	protein binding; cytosol; Ras protein signal transduction; epidermal growth factor receptor signaling pathway; activation of MAPK activity;
UBB	5	protein binding; cytosol; plasma membrane; epidermal growth factor receptor signaling pathway; activation of MAPK activity;
UBC	5	protein binding; cytosol; plasma membrane; epidermal growth factor receptor signaling pathway; activation of MAPK activity;
WWOX	5	protein binding; cytoplasm; cytosol; plasma membrane; enzyme binding;
PLCB3	5	cytosol; lipid catabolic process; calcium ion binding; phospholipase C activity; phosphatidylinositol phospholipase C activity;
CHRM1	5	plasma membrane; cell proliferation; protein kinase C-activating G-protein coupled receptor signaling pathway; lipase activity; phosphatidylinositol phospholipase C activity;

Genes shared at least 2 KEGG pathways with PLCE1 (count: 18)

Gene Symbol	Pathway Count	Pathway List
PLCB2	4	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system; Calcium signaling pathway;
PLCB3	4	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system; Calcium signaling pathway;
PLCD1	4	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system; Calcium signaling pathway;
PLCD4	4	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system; Calcium signaling pathway;
PLCG2	4	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system; Calcium signaling pathway;
CDIPT	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
INPP5A	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
INPPL1	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
IPPK	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PI4K2B	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PI4KA	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PIK3C3	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
DGKH	2	Metabolic pathways; Phosphatidylinositol signaling system;
NOS1	2	Metabolic pathways; Calcium signaling pathway;
PIK3CG	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;
ITPR1	2	Phosphatidylinositol signaling system; Calcium signaling pathway;
ITPR2	2	Phosphatidylinositol signaling system; Calcium signaling pathway;
PRKCB	2	Phosphatidylinositol signaling system; Calcium signaling pathway;

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Region: chr10:95753746..96088149 View in gBrowse