ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PI4KA
Previous Symbol	PIK4CA
Symbol Alias	PI4K-ALPHA, pi4K230
Approved Name	phosphatidylinositol 4-kinase, catalytic, alpha
Location	22q11.21
Position	chr22:21061979-21213705, -
External Links	HGNC: 8983 Entrez Gene: 5297 Ensembl: ENSG00000241973 UCSC: uc002zsz.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 3)

ID	Location	Size	Band	Type
CNV_Jarick[2012]_41	chr22:17616020-19792353 (NCBI36 / hg18)	2176334	22q11.21	dup
CNV_Jarick[2012]_42	chr22:19066315-19792353 (NCBI36 / hg18)	726039	22q11.21	dup
CNV_Jarick[2012]_40	chr22:17257787-19792353 (NCBI36 / hg18)	2534567	22q11.21	dup

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005515	protein binding	Molecular Function	IPI[14676841]	910
GO:0005524	ATP binding	Molecular Function		228
GO:0005798	Golgi-associated vesicle	Cellular Component	TAS[8662589]	5
GO:0005829	cytosol	Cellular Component		447
GO:0004430	1-phosphatidylinositol 4-kinase activity	Molecular Function		2
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0048015	phosphatidylinositol-mediated signaling	Biological Process		16
GO:0006644	phospholipid metabolic process	Biological Process		59
GO:0006661	phosphatidylinositol biosynthetic process	Biological Process		12
GO:0007165	signal transduction	Biological Process	NAS[7961848]	171
GO:0007268	synaptic transmission	Biological Process	TAS[8662589]	96

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene
hsa01100	Metabolic pathways	237
hsa00562	Inositol phosphate metabolism	14
hsa04070	Phosphatidylinositol signaling system	19

Genes shared at least 5 GO terms with PI4KA (count: 11)

Gene Symbol	Pathway Count	Pathway List
PIK3C3	7	protein binding; ATP binding; cytosol; small molecule metabolic process; phosphatidylinositol-mediated signaling; phospholipid metabolic process; phosphatidylinositol biosynthetic process;
PIK3CG	6	protein binding; ATP binding; cytosol; small molecule metabolic process; phospholipid metabolic process; phosphatidylinositol biosynthetic process;
PIK3R1	6	protein binding; cytosol; small molecule metabolic process; phosphatidylinositol-mediated signaling; phospholipid metabolic process; phosphatidylinositol biosynthetic process;
PRKD1	6	protein binding; ATP binding; cytosol; small molecule metabolic process; phospholipid metabolic process; signal transduction;
PI4K2B	6	ATP binding; cytosol; 1-phosphatidylinositol 4-kinase activity; small molecule metabolic process; phospholipid metabolic process; phosphatidylinositol biosynthetic process;
ADCY4	5	protein binding; ATP binding; small molecule metabolic process; signal transduction; synaptic transmission;
INPPL1	5	protein binding; cytosol; small molecule metabolic process; phospholipid metabolic process; phosphatidylinositol biosynthetic process;
MAPK1	5	protein binding; ATP binding; cytosol; signal transduction; synaptic transmission;
MTMR2	5	protein binding; cytosol; small molecule metabolic process; phospholipid metabolic process; phosphatidylinositol biosynthetic process;
PRKCB	5	protein binding; ATP binding; cytosol; signal transduction; synaptic transmission;
CHKA	5	ATP binding; cytosol; small molecule metabolic process; phospholipid metabolic process; signal transduction;

Genes shared at least 2 KEGG pathways with PI4KA (count: 14)

Gene Symbol	Pathway Count	Pathway List
CDIPT	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
INPP5A	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
INPPL1	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
IPPK	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PI4K2B	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PIK3C3	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCB2	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCB3	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCD1	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCD4	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCE1	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCG2	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
DGKH	2	Metabolic pathways; Phosphatidylinositol signaling system;
PIK3CG	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;

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Region: chr22:21061979..21213705 View in gBrowse