ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PI4KA
Previous Symbol	PIK4CA
Symbol Alias	PI4K-ALPHA, pi4K230
Approved Name	phosphatidylinositol 4-kinase, catalytic, alpha
Location	22q11.21
Position	chr22:21061979-21213705, -1
External Links	HGNC: 8983 Entrez Gene: 5297 Ensembl: ENSG00000241973 UCSC: uc002zsz.5
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 3)

ID	Location	Size	Band	Type
CNV_Jarick[2012]_41	chr22:17616020-19792353 (NCBI36 / hg18)	2176334	22q11.21	dup
CNV_Jarick[2012]_42	chr22:19066315-19792353 (NCBI36 / hg18)	726039	22q11.21	dup
CNV_Jarick[2012]_40	chr22:17257787-19792353 (NCBI36 / hg18)	2534567	22q11.21	dup

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006661	phosphatidylinositol biosynthetic process	biological process	TAS	13
GO:0004430	1-phosphatidylinositol 4-kinase activity	molecular function	IEA	2
GO:0005524	ATP binding	molecular function	IEA	265
GO:0007268	synaptic transmission	biological process	TAS[8662589]	103
GO:0044281	small molecule metabolic process	biological process	TAS	270
GO:0005798	Golgi-associated vesicle	cellular component	TAS[8662589]	5
GO:0005829	cytosol	cellular component	TAS	485
GO:0048015	phosphatidylinositol-mediated signaling	biological process	IEA	20
GO:0007165	signal transduction	biological process	NAS[7961848]	189
GO:0005515	protein binding	molecular function	IPI[14676841]	1015
GO:0006644	phospholipid metabolic process	biological process	TAS	61

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00562	Inositol phosphate metabolism	12
hsa04070	Phosphatidylinositol signaling system	19

Genes shared at least 5 GO terms with PI4KA (count: 12)

Gene Symbol	Pathway Count	Pathway List
PIK3C3	7	phosphatidylinositol biosynthetic process; ATP binding; small molecule metabolic process; cytosol; phosphatidylinositol-mediated signaling; protein binding; phospholipid metabolic process;
PIK3R1	6	phosphatidylinositol biosynthetic process; small molecule metabolic process; cytosol; phosphatidylinositol-mediated signaling; protein binding; phospholipid metabolic process;
PIK3C2G	6	phosphatidylinositol biosynthetic process; ATP binding; small molecule metabolic process; cytosol; phosphatidylinositol-mediated signaling; phospholipid metabolic process;
PI4K2B	6	phosphatidylinositol biosynthetic process; 1-phosphatidylinositol 4-kinase activity; ATP binding; small molecule metabolic process; cytosol; phospholipid metabolic process;
PIK3CG	6	phosphatidylinositol biosynthetic process; ATP binding; small molecule metabolic process; cytosol; protein binding; phospholipid metabolic process;
PRKD1	6	ATP binding; small molecule metabolic process; cytosol; signal transduction; protein binding; phospholipid metabolic process;
MTMR2	5	phosphatidylinositol biosynthetic process; small molecule metabolic process; cytosol; protein binding; phospholipid metabolic process;
INPPL1	5	phosphatidylinositol biosynthetic process; small molecule metabolic process; cytosol; protein binding; phospholipid metabolic process;
ADCY4	5	ATP binding; synaptic transmission; small molecule metabolic process; signal transduction; protein binding;
CHKA	5	ATP binding; small molecule metabolic process; cytosol; signal transduction; phospholipid metabolic process;
PDPK1	5	ATP binding; synaptic transmission; cytosol; phosphatidylinositol-mediated signaling; protein binding;
MAPK1	5	ATP binding; synaptic transmission; cytosol; signal transduction; protein binding;

Genes shared at least 2 KEGG pathways with PI4KA (count: 11)

Gene Symbol	Pathway Count	Pathway List
INPPL1	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCD1	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCD4	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PIK3C3	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCG2	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCB2	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;
INPP5A	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCB3	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PTPMT1	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCE1	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PIK3CG	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;

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Region: chr22:21061979..21213705 View in gBrowse