ADHDgene Database

Gene Report

Basic Info

Approved Symbol	CHKA
Previous Symbol	CHK
Symbol Alias	CKI
Approved Name	choline kinase alpha
Previous Name	choline kinase
Location	11q13.1
Position	chr11:67820326-67888858, -
External Links	HGNC: 1937 Entrez Gene: 1119 Ensembl: ENSG00000110721 UCSC: uc001onj.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006657	CDP-choline pathway	Biological Process	IDA[19915674]; TAS[10363580]	1
GO:0006869	lipid transport	Biological Process	TAS[10363580]	12
GO:0006646	phosphatidylethanolamine biosynthetic process	Biological Process	IDA[19915674]	2
GO:0006656	phosphatidylcholine biosynthetic process	Biological Process	IDA[19915674]	6
GO:0006629	lipid metabolic process	Biological Process	TAS[10363580]	51
GO:0006644	phospholipid metabolic process	Biological Process		59
GO:0005524	ATP binding	Molecular Function		228
GO:0005829	cytosol	Cellular Component		447
GO:0004305	ethanolamine kinase activity	Molecular Function	IDA[19915674]	1
GO:0004871	signal transducer activity	Molecular Function	TAS[10363580]	49
GO:0004103	choline kinase activity	Molecular Function	IDA[19915674]	1
GO:0004104	cholinesterase activity	Molecular Function		3
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0042803	protein homodimerization activity	Molecular Function		113
GO:0046474	glycerophospholipid biosynthetic process	Biological Process		30
GO:0008144	drug binding	Molecular Function	IDA[19915674]	19
GO:0007165	signal transduction	Biological Process	TAS[10363580]	171
GO:0033265	choline binding	Molecular Function		2
GO:0019695	choline metabolic process	Biological Process		3

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00564	Glycerophospholipid metabolism	22

Genes shared at least 5 GO terms with CHKA (count: 6)

Gene Symbol	Pathway Count	Pathway List
ACHE	7	phosphatidylcholine biosynthetic process; phospholipid metabolic process; cholinesterase activity; small molecule metabolic process; protein homodimerization activity; glycerophospholipid biosynthetic process; choline metabolic process;
LPIN1	6	phosphatidylethanolamine biosynthetic process; phosphatidylcholine biosynthetic process; phospholipid metabolic process; cytosol; small molecule metabolic process; glycerophospholipid biosynthetic process;
PEMT	5	phosphatidylcholine biosynthetic process; lipid metabolic process; phospholipid metabolic process; small molecule metabolic process; glycerophospholipid biosynthetic process;
MGLL	5	lipid metabolic process; phospholipid metabolic process; small molecule metabolic process; protein homodimerization activity; glycerophospholipid biosynthetic process;
PI4KA	5	phospholipid metabolic process; ATP binding; cytosol; small molecule metabolic process; signal transduction;
PRKD1	5	phospholipid metabolic process; ATP binding; cytosol; small molecule metabolic process; signal transduction;

Genes shared at least 2 KEGG pathways with CHKA (count: 19)

Gene Symbol	Pathway Count	Pathway List
CDIPT	2	Metabolic pathways; Glycerophospholipid metabolism;
DGKH	2	Metabolic pathways; Glycerophospholipid metabolism;
GPAT2	2	Metabolic pathways; Glycerophospholipid metabolism;
LPCAT1	2	Metabolic pathways; Glycerophospholipid metabolism;
LPCAT4	2	Metabolic pathways; Glycerophospholipid metabolism;
MBOAT1	2	Metabolic pathways; Glycerophospholipid metabolism;
MBOAT2	2	Metabolic pathways; Glycerophospholipid metabolism;
PEMT	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G10	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G1B	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G2A	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G2D	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G2E	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G3	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G4B	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G5	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G6	2	Metabolic pathways; Glycerophospholipid metabolism;
PLD1	2	Metabolic pathways; Glycerophospholipid metabolism;
PLD2	2	Metabolic pathways; Glycerophospholipid metabolism;

View in gBrowse

Region: chr11:67820326..67888858 View in gBrowse