ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	LPCAT1
Previous Symbol	AYTL2
Symbol Alias	FLJ12443
Approved Name	lysophosphatidylcholine acyltransferase 1
Previous Name	"acyltransferase like 2"
Location	5p15.33
Position	chr5:1456595-1524092, -1
External Links	HGNC: 25718 Entrez Gene: 79888 Ensembl: ENSG00000153395 UCSC: uc003jcm.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 17)

Literature-origin SNPs (count: 0)

LD-proxies (count: 17)

rs_ID	Location	Functional Annotation
rs11133792	chr5:1477231(Fwd)	downstream_gene_variant; intron_variant; NMD_transcript_variant
rs12654851	chr5:1454004(Fwd)	downstream_gene_variant
rs11750173	chr5:1460131(Fwd)	downstream_gene_variant; intron_variant; NMD_transcript_variant
rs2292023	chr5:1461389(Fwd)	3_prime_UTR_variant; downstream_gene_variant; NMD_transcript_variant
rs9728	chr5:1462098(Fwd)	3_prime_UTR_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant
rs2277006	chr5:1466919(Fwd)	nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant; synonymous_variant
rs4608970	chr5:1519197(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant
rs2963282	chr5:1512208(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant
rs2962041	chr5:1511222(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant
rs2078247	chr5:1452280(Fwd)	downstream_gene_variant
rs17588991	chr5:1501695(Fwd)	nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant; synonymous_variant
rs8352	chr5:1463051(Fwd)	3_prime_UTR_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant
rs27052	chr5:1470069(Fwd)	intron_variant; NMD_transcript_variant; upstream_gene_variant
rs27053	chr5:1470578(Fwd)	intron_variant; NMD_transcript_variant; upstream_gene_variant
rs27056	chr5:1473977(Fwd)	intron_variant; NMD_transcript_variant
rs31491	chr5:1477310(Fwd)	downstream_gene_variant; intron_variant; NMD_transcript_variant
rs2937652	chr5:1460132(Fwd)	downstream_gene_variant; intron_variant; NMD_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
5p	chr5:0-48400000	1 (1/0/0)

Gene related GO terms (count: 21)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0019432	triglyceride biosynthetic process	biological process	TAS	12
GO:0006644	phospholipid metabolic process	biological process	TAS	61
GO:0043129	surfactant homeostasis	biological process	IEA	3
GO:0044281	small molecule metabolic process	biological process	TAS	270
GO:0000139	Golgi membrane	cellular component	IEA	106
GO:2001246	negative regulation of phosphatidylcholine biosynthetic process	biological process	IEA	1
GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity	molecular function	ISS	1
GO:0005783	endoplasmic reticulum	cellular component	ISS	111
GO:0060041	retina development in camera-type eye	biological process	IEA	9
GO:0005509	calcium ion binding	molecular function	IEA	140
GO:0036148	phosphatidylglycerol acyl-chain remodeling	biological process	TAS	10
GO:0008654	phospholipid biosynthetic process	biological process	ISS	3
GO:0045732	positive regulation of protein catabolic process	biological process	IEA	9
GO:0006654	phosphatidic acid biosynthetic process	biological process	TAS	12
GO:0044255	cellular lipid metabolic process	biological process	TAS	33
GO:0036151	phosphatidylcholine acyl-chain remodeling	biological process	TAS	15
GO:0005794	Golgi apparatus	cellular component	ISS	174
GO:0016021	integral to membrane	cellular component	IEA	932
GO:0047192	1-alkylglycerophosphocholine O-acetyltransferase activity	molecular function	IEA	1
GO:0005789	endoplasmic reticulum membrane	cellular component	TAS	159
GO:0046474	glycerophospholipid biosynthetic process	biological process	TAS	30

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with LPCAT1 (count: 31)

Gene Symbol	Pathway Count	Pathway List
LPCAT4	11	triglyceride biosynthetic process; phospholipid metabolic process; small molecule metabolic process; calcium ion binding; phosphatidylglycerol acyl-chain remodeling; phosphatidic acid biosynthetic process; cellular lipid metabolic process; phosphatidylcholine acyl-chain remodeling; integral to membrane; endoplasmic reticulum membrane; glycerophospholipid biosynthetic process;
PLA2G2A	9	phospholipid metabolic process; small molecule metabolic process; endoplasmic reticulum; calcium ion binding; phosphatidylglycerol acyl-chain remodeling; phosphatidic acid biosynthetic process; phosphatidylcholine acyl-chain remodeling; endoplasmic reticulum membrane; glycerophospholipid biosynthetic process;
DGAT2	8	triglyceride biosynthetic process; phospholipid metabolic process; small molecule metabolic process; endoplasmic reticulum; cellular lipid metabolic process; integral to membrane; endoplasmic reticulum membrane; glycerophospholipid biosynthetic process;
PLA2G5	8	phospholipid metabolic process; small molecule metabolic process; calcium ion binding; phosphatidylglycerol acyl-chain remodeling; phosphatidic acid biosynthetic process; phosphatidylcholine acyl-chain remodeling; Golgi apparatus; glycerophospholipid biosynthetic process;
PLA2G2E	7	phospholipid metabolic process; small molecule metabolic process; calcium ion binding; phosphatidylglycerol acyl-chain remodeling; phosphatidic acid biosynthetic process; phosphatidylcholine acyl-chain remodeling; glycerophospholipid biosynthetic process;
PLA2G1B	7	phospholipid metabolic process; small molecule metabolic process; calcium ion binding; phosphatidylglycerol acyl-chain remodeling; phosphatidic acid biosynthetic process; phosphatidylcholine acyl-chain remodeling; glycerophospholipid biosynthetic process;
SMPD4	7	phospholipid metabolic process; small molecule metabolic process; Golgi membrane; endoplasmic reticulum; Golgi apparatus; integral to membrane; endoplasmic reticulum membrane;
PLA2G10	7	phospholipid metabolic process; small molecule metabolic process; calcium ion binding; phosphatidylglycerol acyl-chain remodeling; phosphatidic acid biosynthetic process; phosphatidylcholine acyl-chain remodeling; glycerophospholipid biosynthetic process;
PLA2G2D	7	phospholipid metabolic process; small molecule metabolic process; calcium ion binding; phosphatidylglycerol acyl-chain remodeling; phosphatidic acid biosynthetic process; phosphatidylcholine acyl-chain remodeling; glycerophospholipid biosynthetic process;
PLA2G4B	7	phospholipid metabolic process; small molecule metabolic process; calcium ion binding; phosphatidylglycerol acyl-chain remodeling; phosphatidic acid biosynthetic process; phosphatidylcholine acyl-chain remodeling; glycerophospholipid biosynthetic process;
PLD1	7	phospholipid metabolic process; small molecule metabolic process; Golgi membrane; phosphatidic acid biosynthetic process; Golgi apparatus; endoplasmic reticulum membrane; glycerophospholipid biosynthetic process;
PNPLA8	7	phospholipid metabolic process; small molecule metabolic process; Golgi membrane; phosphatidylcholine acyl-chain remodeling; integral to membrane; endoplasmic reticulum membrane; glycerophospholipid biosynthetic process;
GPAT2	6	triglyceride biosynthetic process; phospholipid metabolic process; small molecule metabolic process; phosphatidic acid biosynthetic process; integral to membrane; glycerophospholipid biosynthetic process;
PNPLA3	6	triglyceride biosynthetic process; phospholipid metabolic process; small molecule metabolic process; integral to membrane; endoplasmic reticulum membrane; glycerophospholipid biosynthetic process;
ELOVL7	6	triglyceride biosynthetic process; small molecule metabolic process; endoplasmic reticulum; cellular lipid metabolic process; integral to membrane; endoplasmic reticulum membrane;
LPIN1	6	triglyceride biosynthetic process; phospholipid metabolic process; small molecule metabolic process; cellular lipid metabolic process; endoplasmic reticulum membrane; glycerophospholipid biosynthetic process;
PLA2G3	6	phospholipid metabolic process; small molecule metabolic process; calcium ion binding; phosphatidylglycerol acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; glycerophospholipid biosynthetic process;
STS	6	phospholipid metabolic process; small molecule metabolic process; endoplasmic reticulum; Golgi apparatus; integral to membrane; endoplasmic reticulum membrane;
PLA2G16	6	phospholipid metabolic process; small molecule metabolic process; endoplasmic reticulum; phosphatidylcholine acyl-chain remodeling; integral to membrane; glycerophospholipid biosynthetic process;
MBOAT2	6	phospholipid metabolic process; small molecule metabolic process; phosphatidylcholine acyl-chain remodeling; integral to membrane; endoplasmic reticulum membrane; glycerophospholipid biosynthetic process;
CDIPT	6	phospholipid metabolic process; small molecule metabolic process; Golgi membrane; integral to membrane; endoplasmic reticulum membrane; glycerophospholipid biosynthetic process;
ELOVL6	5	triglyceride biosynthetic process; small molecule metabolic process; endoplasmic reticulum; cellular lipid metabolic process; endoplasmic reticulum membrane;
TPTE2	5	phospholipid metabolic process; small molecule metabolic process; Golgi membrane; integral to membrane; endoplasmic reticulum membrane;
PLD3	5	phospholipid metabolic process; small molecule metabolic process; integral to membrane; endoplasmic reticulum membrane; glycerophospholipid biosynthetic process;
MBOAT1	5	phospholipid metabolic process; small molecule metabolic process; integral to membrane; endoplasmic reticulum membrane; glycerophospholipid biosynthetic process;
PLA2G4C	5	phospholipid metabolic process; small molecule metabolic process; phosphatidylcholine acyl-chain remodeling; endoplasmic reticulum membrane; glycerophospholipid biosynthetic process;
PEMT	5	phospholipid metabolic process; small molecule metabolic process; integral to membrane; endoplasmic reticulum membrane; glycerophospholipid biosynthetic process;
PLD2	5	phospholipid metabolic process; small molecule metabolic process; phosphatidic acid biosynthetic process; endoplasmic reticulum membrane; glycerophospholipid biosynthetic process;
ACHE	5	phospholipid metabolic process; small molecule metabolic process; retina development in camera-type eye; Golgi apparatus; glycerophospholipid biosynthetic process;
DSE	5	small molecule metabolic process; Golgi membrane; endoplasmic reticulum; Golgi apparatus; integral to membrane;
FADS1	5	small molecule metabolic process; phospholipid biosynthetic process; cellular lipid metabolic process; integral to membrane; endoplasmic reticulum membrane;

Genes shared at least 2 KEGG pathways with LPCAT1 (count: 0)

View in gBrowse

Region: chr5:1456595..1524092 View in gBrowse