ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0008144
Name drug binding
Type molecular function
No. of Genes in ADHDgene  20
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 20)

Literature-origin genes (count: 10)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 5p15.3 70(43/26/1) IEA
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 10q25 2(0/2/0) IEA
DRD2 dopamine receptor D2 11q22-q23 10(3/7/0) IDA[8413587]
DRD4 dopamine receptor D4 11p15.5 67(49/18/0) IDA[8413587]
CNR1 cannabinoid receptor 1 (brain) 6q14-q15 1(1/0/0) IEA
ADRB1 adrenoceptor beta 1 10q25.3 2(0/2/0) IEA
DRD3 dopamine receptor D3 3q13.3 8(1/7/0) IDA[8413587]; ISS
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Xq23 5(2/3/0) IDA[15831837]
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 6q13 14(5/9/0) IEA
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 13q14-q21 13(7/6/0) IDA[15831837]

Genes from other sources Help (count: 10)

Approved Symbol Approved Name Source Evidence[PMID]
CHKA choline kinase alpha Mapped by significant region IDA[19915674]
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 Mapped by Literature SNP IC
PDE4D phosphodiesterase 4D, cAMP-specific Mapped by CNV IPI[15938621]
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) Mapped by significant region IEA
DHFRP1 dihydrofolate reductase pseudogene 1 Mapped by significant region IDA[15039552]
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 Mapped by LD-proxy IDA
CHRM3 cholinergic receptor, muscarinic 3 Mapped by CNV; Mapped by PBA pathway IEA
PDE2A phosphodiesterase 2A, cGMP-stimulated Mapped by significant region IDA[15938621]; IPI[15938621]
SIGMAR1 sigma non-opioid intracellular receptor 1 Mapped by LD-proxy TAS[8954936]
CHRM1 cholinergic receptor, muscarinic 1 Mapped by significant region; Mapped by PBA pathway IEA