ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	LPCAT4
Previous Symbol	AYTL3, AGPAT7
Symbol Alias	FLJ10257, LPAAT-eta, LPEAT2
Approved Name	lysophosphatidylcholine acyltransferase 4
Previous Name	acyltransferase like 3, "1-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta)"
Name Alias	lysophosphatidylethanolamine acyltransferase 2
Location	15q14
Position	chr15:34651089-34659395, -
External Links	HGNC: 30059 Entrez Gene: 254531 Ensembl: ENSG00000176454 UCSC: uc001zig.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_44	chr15:30688712-32587887 (NCBI Build 36.1 (hg18))	1871368	15q13.3-15q14	Gain	Maternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 14)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 14)

ID	Name	Type	No. of Genes in ADHDgene
GO:0044255	cellular lipid metabolic process	Biological Process	30
GO:0044281	small molecule metabolic process	Biological Process	248
GO:0046474	glycerophospholipid biosynthetic process	Biological Process	30
GO:0036151	phosphatidylcholine acyl-chain remodeling	Biological Process	15
GO:0036152	phosphatidylethanolamine acyl-chain remodeling	Biological Process	15
GO:0036148	phosphatidylglycerol acyl-chain remodeling	Biological Process	10
GO:0036150	phosphatidylserine acyl-chain remodeling	Biological Process	10
GO:0016746	transferase activity, transferring acyl groups	Molecular Function	10
GO:0019432	triglyceride biosynthetic process	Biological Process	12
GO:0006654	phosphatidic acid biosynthetic process	Biological Process	12
GO:0016021	integral to membrane	Cellular Component	845
GO:0005789	endoplasmic reticulum membrane	Cellular Component	140
GO:0006644	phospholipid metabolic process	Biological Process	59
GO:0005509	calcium ion binding	Molecular Function	124

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene
hsa01100	Metabolic pathways	237
hsa00564	Glycerophospholipid metabolism	22
hsa00565	Ether lipid metabolism	15

Genes shared at least 5 GO terms with LPCAT4 (count: 25)

Gene Symbol	Pathway Count	Pathway List
LPCAT1	11	cellular lipid metabolic process; small molecule metabolic process; glycerophospholipid biosynthetic process; phosphatidylcholine acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling; triglyceride biosynthetic process; phosphatidic acid biosynthetic process; integral to membrane; endoplasmic reticulum membrane; phospholipid metabolic process; calcium ion binding;
PLA2G2A	10	small molecule metabolic process; glycerophospholipid biosynthetic process; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling; phosphatidylserine acyl-chain remodeling; phosphatidic acid biosynthetic process; endoplasmic reticulum membrane; phospholipid metabolic process; calcium ion binding;
PLA2G10	9	small molecule metabolic process; glycerophospholipid biosynthetic process; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling; phosphatidylserine acyl-chain remodeling; phosphatidic acid biosynthetic process; phospholipid metabolic process; calcium ion binding;
PLA2G1B	9	small molecule metabolic process; glycerophospholipid biosynthetic process; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling; phosphatidylserine acyl-chain remodeling; phosphatidic acid biosynthetic process; phospholipid metabolic process; calcium ion binding;
PLA2G2D	9	small molecule metabolic process; glycerophospholipid biosynthetic process; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling; phosphatidylserine acyl-chain remodeling; phosphatidic acid biosynthetic process; phospholipid metabolic process; calcium ion binding;
PLA2G2E	9	small molecule metabolic process; glycerophospholipid biosynthetic process; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling; phosphatidylserine acyl-chain remodeling; phosphatidic acid biosynthetic process; phospholipid metabolic process; calcium ion binding;
PLA2G4B	9	small molecule metabolic process; glycerophospholipid biosynthetic process; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling; phosphatidylserine acyl-chain remodeling; phosphatidic acid biosynthetic process; phospholipid metabolic process; calcium ion binding;
PLA2G5	9	small molecule metabolic process; glycerophospholipid biosynthetic process; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling; phosphatidylserine acyl-chain remodeling; phosphatidic acid biosynthetic process; phospholipid metabolic process; calcium ion binding;
DGAT2	7	cellular lipid metabolic process; small molecule metabolic process; glycerophospholipid biosynthetic process; triglyceride biosynthetic process; integral to membrane; endoplasmic reticulum membrane; phospholipid metabolic process;
MBOAT1	7	small molecule metabolic process; glycerophospholipid biosynthetic process; phosphatidylethanolamine acyl-chain remodeling; phosphatidylserine acyl-chain remodeling; integral to membrane; endoplasmic reticulum membrane; phospholipid metabolic process;
MBOAT2	7	small molecule metabolic process; glycerophospholipid biosynthetic process; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; integral to membrane; endoplasmic reticulum membrane; phospholipid metabolic process;
PLA2G16	7	small molecule metabolic process; glycerophospholipid biosynthetic process; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; phosphatidylserine acyl-chain remodeling; integral to membrane; phospholipid metabolic process;
PLA2G3	7	small molecule metabolic process; glycerophospholipid biosynthetic process; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling; phospholipid metabolic process; calcium ion binding;
PNPLA8	7	small molecule metabolic process; glycerophospholipid biosynthetic process; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; integral to membrane; endoplasmic reticulum membrane; phospholipid metabolic process;
LPIN1	6	cellular lipid metabolic process; small molecule metabolic process; glycerophospholipid biosynthetic process; triglyceride biosynthetic process; endoplasmic reticulum membrane; phospholipid metabolic process;
GPAT2	6	small molecule metabolic process; glycerophospholipid biosynthetic process; triglyceride biosynthetic process; phosphatidic acid biosynthetic process; integral to membrane; phospholipid metabolic process;
PLA2G4C	6	small molecule metabolic process; glycerophospholipid biosynthetic process; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; endoplasmic reticulum membrane; phospholipid metabolic process;
PNPLA3	6	small molecule metabolic process; glycerophospholipid biosynthetic process; triglyceride biosynthetic process; integral to membrane; endoplasmic reticulum membrane; phospholipid metabolic process;
ELOVL7	5	cellular lipid metabolic process; small molecule metabolic process; triglyceride biosynthetic process; integral to membrane; endoplasmic reticulum membrane;
CDIPT	5	small molecule metabolic process; glycerophospholipid biosynthetic process; integral to membrane; endoplasmic reticulum membrane; phospholipid metabolic process;
PEMT	5	small molecule metabolic process; glycerophospholipid biosynthetic process; integral to membrane; endoplasmic reticulum membrane; phospholipid metabolic process;
PLA2G6	5	small molecule metabolic process; glycerophospholipid biosynthetic process; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; phospholipid metabolic process;
PLD1	5	small molecule metabolic process; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process; endoplasmic reticulum membrane; phospholipid metabolic process;
PLD2	5	small molecule metabolic process; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process; endoplasmic reticulum membrane; phospholipid metabolic process;
PLD3	5	small molecule metabolic process; glycerophospholipid biosynthetic process; integral to membrane; endoplasmic reticulum membrane; phospholipid metabolic process;

Genes shared at least 2 KEGG pathways with LPCAT4 (count: 21)

Gene Symbol	Pathway Count	Pathway List
LPCAT1	3	Metabolic pathways; Glycerophospholipid metabolism; Ether lipid metabolism;
PLA2G10	3	Metabolic pathways; Glycerophospholipid metabolism; Ether lipid metabolism;
PLA2G1B	3	Metabolic pathways; Glycerophospholipid metabolism; Ether lipid metabolism;
PLA2G2A	3	Metabolic pathways; Glycerophospholipid metabolism; Ether lipid metabolism;
PLA2G2D	3	Metabolic pathways; Glycerophospholipid metabolism; Ether lipid metabolism;
PLA2G2E	3	Metabolic pathways; Glycerophospholipid metabolism; Ether lipid metabolism;
PLA2G3	3	Metabolic pathways; Glycerophospholipid metabolism; Ether lipid metabolism;
PLA2G4B	3	Metabolic pathways; Glycerophospholipid metabolism; Ether lipid metabolism;
PLA2G5	3	Metabolic pathways; Glycerophospholipid metabolism; Ether lipid metabolism;
PLA2G6	3	Metabolic pathways; Glycerophospholipid metabolism; Ether lipid metabolism;
PLD1	3	Metabolic pathways; Glycerophospholipid metabolism; Ether lipid metabolism;
PLD2	3	Metabolic pathways; Glycerophospholipid metabolism; Ether lipid metabolism;
CDIPT	2	Metabolic pathways; Glycerophospholipid metabolism;
CHKA	2	Metabolic pathways; Glycerophospholipid metabolism;
DGKH	2	Metabolic pathways; Glycerophospholipid metabolism;
GPAT2	2	Metabolic pathways; Glycerophospholipid metabolism;
MBOAT1	2	Metabolic pathways; Glycerophospholipid metabolism;
MBOAT2	2	Metabolic pathways; Glycerophospholipid metabolism;
PAFAH1B1	2	Metabolic pathways; Ether lipid metabolism;
PAFAH1B2	2	Metabolic pathways; Ether lipid metabolism;
PEMT	2	Metabolic pathways; Glycerophospholipid metabolism;

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Region: chr15:34651089..34659395 View in gBrowse