ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PEMT
Symbol Alias	PEMPT, PEMT2
Approved Name	phosphatidylethanolamine N-methyltransferase
Location	17p11.2
Position	chr17:17408877-17495022, -
External Links	HGNC: 8830 Entrez Gene: 10400 Ensembl: ENSG00000133027 UCSC: uc002grl.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
17p11	chr17:16000000-24000000	3 (2/0/1)

Gene related GO terms (count: 12)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000773	phosphatidyl-N-methylethanolamine N-methyltransferase activity	Molecular Function		1
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0004608	phosphatidylethanolamine N-methyltransferase activity	Molecular Function		1
GO:0006644	phospholipid metabolic process	Biological Process		59
GO:0006629	lipid metabolic process	Biological Process	TAS[9989271]	51
GO:0016021	integral to membrane	Cellular Component		845
GO:0031966	mitochondrial membrane	Cellular Component		12
GO:0006656	phosphatidylcholine biosynthetic process	Biological Process		6
GO:0008283	cell proliferation	Biological Process	TAS[9989271]	60
GO:0080101	phosphatidyl-N-dimethylethanolamine N-methyltransferase activity	Molecular Function		1
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0046474	glycerophospholipid biosynthetic process	Biological Process		30

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00564	Glycerophospholipid metabolism	22

Genes shared at least 5 GO terms with PEMT (count: 14)

Gene Symbol	Pathway Count	Pathway List
CDIPT	5	endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; small molecule metabolic process; glycerophospholipid biosynthetic process;
DGAT2	5	endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; small molecule metabolic process; glycerophospholipid biosynthetic process;
LPCAT1	5	endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; small molecule metabolic process; glycerophospholipid biosynthetic process;
LPCAT4	5	endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; small molecule metabolic process; glycerophospholipid biosynthetic process;
LPIN1	5	endoplasmic reticulum membrane; phospholipid metabolic process; phosphatidylcholine biosynthetic process; small molecule metabolic process; glycerophospholipid biosynthetic process;
MBOAT1	5	endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; small molecule metabolic process; glycerophospholipid biosynthetic process;
MBOAT2	5	endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; small molecule metabolic process; glycerophospholipid biosynthetic process;
MGLL	5	endoplasmic reticulum membrane; phospholipid metabolic process; lipid metabolic process; small molecule metabolic process; glycerophospholipid biosynthetic process;
PLD3	5	endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; small molecule metabolic process; glycerophospholipid biosynthetic process;
PNPLA3	5	endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; small molecule metabolic process; glycerophospholipid biosynthetic process;
PNPLA8	5	endoplasmic reticulum membrane; phospholipid metabolic process; integral to membrane; small molecule metabolic process; glycerophospholipid biosynthetic process;
ACHE	5	phospholipid metabolic process; phosphatidylcholine biosynthetic process; cell proliferation; small molecule metabolic process; glycerophospholipid biosynthetic process;
CHKA	5	phospholipid metabolic process; lipid metabolic process; phosphatidylcholine biosynthetic process; small molecule metabolic process; glycerophospholipid biosynthetic process;
SLC44A1	5	phospholipid metabolic process; integral to membrane; phosphatidylcholine biosynthetic process; small molecule metabolic process; glycerophospholipid biosynthetic process;

Genes shared at least 2 KEGG pathways with PEMT (count: 19)

Gene Symbol	Pathway Count	Pathway List
CDIPT	2	Metabolic pathways; Glycerophospholipid metabolism;
CHKA	2	Metabolic pathways; Glycerophospholipid metabolism;
DGKH	2	Metabolic pathways; Glycerophospholipid metabolism;
GPAT2	2	Metabolic pathways; Glycerophospholipid metabolism;
LPCAT1	2	Metabolic pathways; Glycerophospholipid metabolism;
LPCAT4	2	Metabolic pathways; Glycerophospholipid metabolism;
MBOAT1	2	Metabolic pathways; Glycerophospholipid metabolism;
MBOAT2	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G10	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G1B	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G2A	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G2D	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G2E	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G3	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G4B	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G5	2	Metabolic pathways; Glycerophospholipid metabolism;
PLA2G6	2	Metabolic pathways; Glycerophospholipid metabolism;
PLD1	2	Metabolic pathways; Glycerophospholipid metabolism;
PLD2	2	Metabolic pathways; Glycerophospholipid metabolism;

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Region: chr17:17408877..17495022 View in gBrowse