ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PNPLA8
Symbol Alias	IPLA2G, IPLA2-2, IPLA2(GAMMA)
Approved Name	patatin-like phospholipase domain containing 8
Location	7q31
Position	chr7:108110866-108210110, -
External Links	HGNC: 28900 Entrez Gene: 50640 Ensembl: ENSG00000135241 UCSC: uc003vff.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 26)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016298	lipase activity	Molecular Function		49
GO:0004091	carboxylesterase activity	Molecular Function		40

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0048471	perinuclear region of cytoplasm	Cellular Component		87
GO:0047499	calcium-independent phospholipase A2 activity	Molecular Function	IDA[15695510]	3
GO:0046474	glycerophospholipid biosynthetic process	Biological Process		30
GO:0046338	phosphatidylethanolamine catabolic process	Biological Process	IDA[15695510]	1
GO:0050482	arachidonic acid secretion	Biological Process	IDA[10833412]	7
GO:0034638	phosphatidylcholine catabolic process	Biological Process	IDA[15695510]	1
GO:0019369	arachidonic acid metabolic process	Biological Process	IDA[15695510]	6
GO:0016021	integral to membrane	Cellular Component		845
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0043651	linoleic acid metabolic process	Biological Process	IDA[15695510]	3
GO:0036152	phosphatidylethanolamine acyl-chain remodeling	Biological Process		15
GO:0036151	phosphatidylcholine acyl-chain remodeling	Biological Process		15
GO:0005524	ATP binding	Molecular Function	NAS[10744668]	228
GO:0004622	lysophospholipase activity	Molecular Function		5
GO:0001516	prostaglandin biosynthetic process	Biological Process	IDA[15695510]	3
GO:0000139	Golgi membrane	Cellular Component		95
GO:0016020	membrane	Cellular Component	IDA[10833412]	139
GO:0008219	cell death	Biological Process	IDA[15695510]	33
GO:0006644	phospholipid metabolic process	Biological Process		59
GO:0006631	fatty acid metabolic process	Biological Process	IDA[10744668]	15
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0005778	peroxisomal membrane	Cellular Component	IDA[10744668]	8
GO:0005777	peroxisome	Cellular Component	IDA[15695510]	15
GO:0005622	intracellular	Cellular Component	IDA[10744668]	67

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with PNPLA8 (count: 31)

Gene Symbol	Pathway Count	Pathway List
PLA2G4C	11	calcium-independent phospholipase A2 activity; glycerophospholipid biosynthetic process; arachidonic acid metabolic process; lipase activity; small molecule metabolic process; phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; carboxylesterase activity; membrane; phospholipid metabolic process; endoplasmic reticulum membrane;
PLA2G6	10	calcium-independent phospholipase A2 activity; glycerophospholipid biosynthetic process; lipase activity; small molecule metabolic process; phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; carboxylesterase activity; membrane; cell death; phospholipid metabolic process;
PLA2G5	9	perinuclear region of cytoplasm; glycerophospholipid biosynthetic process; arachidonic acid secretion; lipase activity; small molecule metabolic process; phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; carboxylesterase activity; phospholipid metabolic process;
PLA2G4B	9	glycerophospholipid biosynthetic process; arachidonic acid metabolic process; lipase activity; small molecule metabolic process; phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; lysophospholipase activity; carboxylesterase activity; phospholipid metabolic process;
PLD1	8	perinuclear region of cytoplasm; glycerophospholipid biosynthetic process; lipase activity; small molecule metabolic process; Golgi membrane; membrane; phospholipid metabolic process; endoplasmic reticulum membrane;
MGLL	8	glycerophospholipid biosynthetic process; arachidonic acid metabolic process; lipase activity; small molecule metabolic process; lysophospholipase activity; carboxylesterase activity; phospholipid metabolic process; endoplasmic reticulum membrane;
PLA2G10	8	glycerophospholipid biosynthetic process; arachidonic acid metabolic process; lipase activity; small molecule metabolic process; phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; carboxylesterase activity; phospholipid metabolic process;
PLA2G1B	8	glycerophospholipid biosynthetic process; arachidonic acid secretion; lipase activity; small molecule metabolic process; phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; carboxylesterase activity; phospholipid metabolic process;
PLA2G2A	8	glycerophospholipid biosynthetic process; lipase activity; small molecule metabolic process; phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; carboxylesterase activity; phospholipid metabolic process; endoplasmic reticulum membrane;
PNPLA3	8	glycerophospholipid biosynthetic process; lipase activity; integral to membrane; small molecule metabolic process; carboxylesterase activity; membrane; phospholipid metabolic process; endoplasmic reticulum membrane;
PLA2G16	7	perinuclear region of cytoplasm; glycerophospholipid biosynthetic process; integral to membrane; small molecule metabolic process; phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; phospholipid metabolic process;
LPCAT1	7	glycerophospholipid biosynthetic process; integral to membrane; small molecule metabolic process; phosphatidylcholine acyl-chain remodeling; Golgi membrane; phospholipid metabolic process; endoplasmic reticulum membrane;
LPCAT4	7	glycerophospholipid biosynthetic process; integral to membrane; small molecule metabolic process; phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; phospholipid metabolic process; endoplasmic reticulum membrane;
MBOAT2	7	glycerophospholipid biosynthetic process; integral to membrane; small molecule metabolic process; phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; phospholipid metabolic process; endoplasmic reticulum membrane;
PLA2G2D	7	glycerophospholipid biosynthetic process; lipase activity; small molecule metabolic process; phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; carboxylesterase activity; phospholipid metabolic process;
PLA2G2E	7	glycerophospholipid biosynthetic process; lipase activity; small molecule metabolic process; phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; carboxylesterase activity; phospholipid metabolic process;
PLA2G3	7	glycerophospholipid biosynthetic process; lipase activity; small molecule metabolic process; phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; carboxylesterase activity; phospholipid metabolic process;
ACHE	6	perinuclear region of cytoplasm; glycerophospholipid biosynthetic process; small molecule metabolic process; carboxylesterase activity; membrane; phospholipid metabolic process;
DGAT2	6	perinuclear region of cytoplasm; glycerophospholipid biosynthetic process; integral to membrane; small molecule metabolic process; phospholipid metabolic process; endoplasmic reticulum membrane;
CDIPT	6	glycerophospholipid biosynthetic process; integral to membrane; small molecule metabolic process; Golgi membrane; phospholipid metabolic process; endoplasmic reticulum membrane;
MBOAT1	6	glycerophospholipid biosynthetic process; integral to membrane; small molecule metabolic process; phosphatidylethanolamine acyl-chain remodeling; phospholipid metabolic process; endoplasmic reticulum membrane;
PLD3	6	glycerophospholipid biosynthetic process; lipase activity; integral to membrane; small molecule metabolic process; phospholipid metabolic process; endoplasmic reticulum membrane;
FADS1	6	arachidonic acid metabolic process; integral to membrane; small molecule metabolic process; linoleic acid metabolic process; membrane; endoplasmic reticulum membrane;
SMPD4	6	lipase activity; integral to membrane; small molecule metabolic process; Golgi membrane; phospholipid metabolic process; endoplasmic reticulum membrane;
PEMT	5	glycerophospholipid biosynthetic process; integral to membrane; small molecule metabolic process; phospholipid metabolic process; endoplasmic reticulum membrane;
PLD2	5	glycerophospholipid biosynthetic process; lipase activity; small molecule metabolic process; phospholipid metabolic process; endoplasmic reticulum membrane;
ENPP7	5	lipase activity; integral to membrane; small molecule metabolic process; membrane; phospholipid metabolic process;
LYPLA1	5	lipase activity; small molecule metabolic process; lysophospholipase activity; carboxylesterase activity; fatty acid metabolic process;
STS	5	integral to membrane; small molecule metabolic process; membrane; phospholipid metabolic process; endoplasmic reticulum membrane;
TPTE2	5	integral to membrane; small molecule metabolic process; Golgi membrane; phospholipid metabolic process; endoplasmic reticulum membrane;
UGCG	5	integral to membrane; small molecule metabolic process; Golgi membrane; membrane; phospholipid metabolic process;

Genes shared at least 2 KEGG pathways with PNPLA8 (count: 0)

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Region: chr7:108110866..108210110 View in gBrowse