ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PNPLA8
Symbol Alias	IPLA2G, IPLA2-2, iPLA2gamma
Approved Name	patatin-like phospholipase domain containing 8
Location	7q31
Position	chr7:108110866-108210110, -1
External Links	HGNC: 28900 Entrez Gene: 50640 Ensembl: ENSG00000135241 UCSC: uc003vfj.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 24)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005777	peroxisome	cellular component	IDA[15695510]	17
GO:0046474	glycerophospholipid biosynthetic process	biological process	TAS	30
GO:0000139	Golgi membrane	cellular component	IEA	106
GO:0047499	calcium-independent phospholipase A2 activity	molecular function	IDA[15695510]	3
GO:0004622	lysophospholipase activity	molecular function	IEA	5
GO:0016020	membrane	cellular component	IDA[10833412]	155
GO:0034638	phosphatidylcholine catabolic process	biological process	IDA[15695510]	1
GO:0006631	fatty acid metabolic process	biological process	IDA[10744668]	15
GO:0005622	intracellular	cellular component	IDA[10744668]	83
GO:0019369	arachidonic acid metabolic process	biological process	IDA[15695510]	6
GO:0005524	ATP binding	molecular function	NAS[10744668]	265
GO:0044281	small molecule metabolic process	biological process	TAS	270
GO:0008219	cell death	biological process	IDA[15695510]	33
GO:0006644	phospholipid metabolic process	biological process	TAS	61
GO:0036152	phosphatidylethanolamine acyl-chain remodeling	biological process	TAS	15
GO:0048471	perinuclear region of cytoplasm	cellular component	IEA	99
GO:0050482	arachidonic acid secretion	biological process	IDA[10833412]	7
GO:0016021	integral to membrane	cellular component	IEA	932
GO:0043651	linoleic acid metabolic process	biological process	IDA[15695510]	3
GO:0005778	peroxisomal membrane	cellular component	IDA[10744668]	8
GO:0001516	prostaglandin biosynthetic process	biological process	IDA[15695510]	3
GO:0005789	endoplasmic reticulum membrane	cellular component	TAS	159
GO:0036151	phosphatidylcholine acyl-chain remodeling	biological process	TAS	15
GO:0046338	phosphatidylethanolamine catabolic process	biological process	IDA[15695510]	1

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with PNPLA8 (count: 30)

Gene Symbol	Pathway Count	Pathway List
PLA2G4C	9	glycerophospholipid biosynthetic process; calcium-independent phospholipase A2 activity; membrane; arachidonic acid metabolic process; small molecule metabolic process; phospholipid metabolic process; phosphatidylethanolamine acyl-chain remodeling; endoplasmic reticulum membrane; phosphatidylcholine acyl-chain remodeling;
PLA2G6	8	glycerophospholipid biosynthetic process; calcium-independent phospholipase A2 activity; membrane; small molecule metabolic process; cell death; phospholipid metabolic process; phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling;
PLA2G4B	7	glycerophospholipid biosynthetic process; lysophospholipase activity; arachidonic acid metabolic process; small molecule metabolic process; phospholipid metabolic process; phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling;
PLA2G16	7	glycerophospholipid biosynthetic process; small molecule metabolic process; phospholipid metabolic process; phosphatidylethanolamine acyl-chain remodeling; perinuclear region of cytoplasm; integral to membrane; phosphatidylcholine acyl-chain remodeling;
LPCAT1	7	glycerophospholipid biosynthetic process; Golgi membrane; small molecule metabolic process; phospholipid metabolic process; integral to membrane; endoplasmic reticulum membrane; phosphatidylcholine acyl-chain remodeling;
LPCAT4	7	glycerophospholipid biosynthetic process; small molecule metabolic process; phospholipid metabolic process; phosphatidylethanolamine acyl-chain remodeling; integral to membrane; endoplasmic reticulum membrane; phosphatidylcholine acyl-chain remodeling;
PLD1	7	glycerophospholipid biosynthetic process; Golgi membrane; membrane; small molecule metabolic process; phospholipid metabolic process; perinuclear region of cytoplasm; endoplasmic reticulum membrane;
MBOAT2	7	glycerophospholipid biosynthetic process; small molecule metabolic process; phospholipid metabolic process; phosphatidylethanolamine acyl-chain remodeling; integral to membrane; endoplasmic reticulum membrane; phosphatidylcholine acyl-chain remodeling;
PLA2G5	7	glycerophospholipid biosynthetic process; small molecule metabolic process; phospholipid metabolic process; phosphatidylethanolamine acyl-chain remodeling; perinuclear region of cytoplasm; arachidonic acid secretion; phosphatidylcholine acyl-chain remodeling;
CDIPT	6	glycerophospholipid biosynthetic process; Golgi membrane; small molecule metabolic process; phospholipid metabolic process; integral to membrane; endoplasmic reticulum membrane;
MBOAT1	6	glycerophospholipid biosynthetic process; small molecule metabolic process; phospholipid metabolic process; phosphatidylethanolamine acyl-chain remodeling; integral to membrane; endoplasmic reticulum membrane;
MGLL	6	glycerophospholipid biosynthetic process; lysophospholipase activity; arachidonic acid metabolic process; small molecule metabolic process; phospholipid metabolic process; endoplasmic reticulum membrane;
PLA2G2A	6	glycerophospholipid biosynthetic process; small molecule metabolic process; phospholipid metabolic process; phosphatidylethanolamine acyl-chain remodeling; endoplasmic reticulum membrane; phosphatidylcholine acyl-chain remodeling;
PLA2G10	6	glycerophospholipid biosynthetic process; arachidonic acid metabolic process; small molecule metabolic process; phospholipid metabolic process; phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling;
DGAT2	6	glycerophospholipid biosynthetic process; small molecule metabolic process; phospholipid metabolic process; perinuclear region of cytoplasm; integral to membrane; endoplasmic reticulum membrane;
PLA2G1B	6	glycerophospholipid biosynthetic process; small molecule metabolic process; phospholipid metabolic process; phosphatidylethanolamine acyl-chain remodeling; arachidonic acid secretion; phosphatidylcholine acyl-chain remodeling;
PNPLA3	6	glycerophospholipid biosynthetic process; membrane; small molecule metabolic process; phospholipid metabolic process; integral to membrane; endoplasmic reticulum membrane;
FADS1	6	membrane; arachidonic acid metabolic process; small molecule metabolic process; integral to membrane; linoleic acid metabolic process; endoplasmic reticulum membrane;
PLA2G3	5	glycerophospholipid biosynthetic process; small molecule metabolic process; phospholipid metabolic process; phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling;
PLA2G2E	5	glycerophospholipid biosynthetic process; small molecule metabolic process; phospholipid metabolic process; phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling;
PLD3	5	glycerophospholipid biosynthetic process; small molecule metabolic process; phospholipid metabolic process; integral to membrane; endoplasmic reticulum membrane;
ACHE	5	glycerophospholipid biosynthetic process; membrane; small molecule metabolic process; phospholipid metabolic process; perinuclear region of cytoplasm;
PLA2G2D	5	glycerophospholipid biosynthetic process; small molecule metabolic process; phospholipid metabolic process; phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling;
PEMT	5	glycerophospholipid biosynthetic process; small molecule metabolic process; phospholipid metabolic process; integral to membrane; endoplasmic reticulum membrane;
TPTE2	5	Golgi membrane; small molecule metabolic process; phospholipid metabolic process; integral to membrane; endoplasmic reticulum membrane;
UGCG	5	Golgi membrane; membrane; small molecule metabolic process; phospholipid metabolic process; integral to membrane;
SMPD4	5	Golgi membrane; small molecule metabolic process; phospholipid metabolic process; integral to membrane; endoplasmic reticulum membrane;
ATP2A1	5	membrane; ATP binding; perinuclear region of cytoplasm; integral to membrane; endoplasmic reticulum membrane;
STS	5	membrane; small molecule metabolic process; phospholipid metabolic process; integral to membrane; endoplasmic reticulum membrane;
ADCY2	5	membrane; intracellular; ATP binding; small molecule metabolic process; integral to membrane;

Genes shared at least 2 KEGG pathways with PNPLA8 (count: 0)

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Region: chr7:108110866..108210110 View in gBrowse