ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PLA2G4C
Symbol Alias	cPLA2-gamma
Approved Name	phospholipase A2, group IVC (cytosolic, calcium-independent)
Location	19q13.3
Position	chr19:48551100-48614109, -
External Links	HGNC: 9037 Entrez Gene: 8605 Ensembl: ENSG00000105499 UCSC: uc002phx.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 18)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016298	lipase activity	Molecular Function		49
GO:0004091	carboxylesterase activity	Molecular Function		40

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0047499	calcium-independent phospholipase A2 activity	Molecular Function	IDA[10085124]	3
GO:0046475	glycerophospholipid catabolic process	Biological Process	IDA[10085124]	3
GO:0036152	phosphatidylethanolamine acyl-chain remodeling	Biological Process		15
GO:0036151	phosphatidylcholine acyl-chain remodeling	Biological Process		15
GO:0046474	glycerophospholipid biosynthetic process	Biological Process		30
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0019369	arachidonic acid metabolic process	Biological Process	NAS[10085124]	6
GO:0036149	phosphatidylinositol acyl-chain remodeling	Biological Process		8
GO:0035556	intracellular signal transduction	Biological Process	NAS[10085124]	44
GO:0007567	parturition	Biological Process	NAS[10085124]	2
GO:0016020	membrane	Cellular Component	TAS[10085124]	139
GO:0006644	phospholipid metabolic process	Biological Process		59
GO:0006954	inflammatory response	Biological Process	NAS[10085124]	51
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0005829	cytosol	Cellular Component	TAS[10085124]	447
GO:0005543	phospholipid binding	Molecular Function	NAS[10085124]	61

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with PLA2G4C (count: 26)

Gene Symbol	Pathway Count	Pathway List
PLA2G4B	12	glycerophospholipid catabolic process; phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; glycerophospholipid biosynthetic process; small molecule metabolic process; arachidonic acid metabolic process; lipase activity; parturition; phospholipid metabolic process; inflammatory response; cytosol; carboxylesterase activity;
PNPLA8	11	calcium-independent phospholipase A2 activity; phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; glycerophospholipid biosynthetic process; small molecule metabolic process; arachidonic acid metabolic process; lipase activity; membrane; phospholipid metabolic process; endoplasmic reticulum membrane; carboxylesterase activity;
PLA2G6	10	calcium-independent phospholipase A2 activity; phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; glycerophospholipid biosynthetic process; small molecule metabolic process; lipase activity; membrane; phospholipid metabolic process; cytosol; carboxylesterase activity;
PLA2G2A	10	phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; glycerophospholipid biosynthetic process; small molecule metabolic process; lipase activity; phosphatidylinositol acyl-chain remodeling; phospholipid metabolic process; endoplasmic reticulum membrane; carboxylesterase activity; phospholipid binding;
PLA2G10	9	phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; glycerophospholipid biosynthetic process; small molecule metabolic process; arachidonic acid metabolic process; lipase activity; phosphatidylinositol acyl-chain remodeling; phospholipid metabolic process; carboxylesterase activity;
PLA2G2D	9	phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; glycerophospholipid biosynthetic process; small molecule metabolic process; lipase activity; phosphatidylinositol acyl-chain remodeling; phospholipid metabolic process; inflammatory response; carboxylesterase activity;
PLA2G2E	9	phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; glycerophospholipid biosynthetic process; small molecule metabolic process; lipase activity; phosphatidylinositol acyl-chain remodeling; phospholipid metabolic process; inflammatory response; carboxylesterase activity;
PLA2G1B	8	phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; glycerophospholipid biosynthetic process; small molecule metabolic process; lipase activity; phosphatidylinositol acyl-chain remodeling; phospholipid metabolic process; carboxylesterase activity;
PLA2G5	8	phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; glycerophospholipid biosynthetic process; small molecule metabolic process; lipase activity; phosphatidylinositol acyl-chain remodeling; phospholipid metabolic process; carboxylesterase activity;
MGLL	8	glycerophospholipid biosynthetic process; small molecule metabolic process; arachidonic acid metabolic process; lipase activity; phospholipid metabolic process; inflammatory response; endoplasmic reticulum membrane; carboxylesterase activity;
PLA2G16	7	phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; glycerophospholipid biosynthetic process; small molecule metabolic process; phosphatidylinositol acyl-chain remodeling; phospholipid metabolic process; cytosol;
PLA2G3	7	phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; glycerophospholipid biosynthetic process; small molecule metabolic process; lipase activity; phospholipid metabolic process; carboxylesterase activity;
PNPLA3	7	glycerophospholipid biosynthetic process; small molecule metabolic process; lipase activity; membrane; phospholipid metabolic process; endoplasmic reticulum membrane; carboxylesterase activity;
LPCAT4	6	phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; glycerophospholipid biosynthetic process; small molecule metabolic process; phospholipid metabolic process; endoplasmic reticulum membrane;
MBOAT2	6	phosphatidylethanolamine acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; glycerophospholipid biosynthetic process; small molecule metabolic process; phospholipid metabolic process; endoplasmic reticulum membrane;
PLD1	6	glycerophospholipid biosynthetic process; small molecule metabolic process; lipase activity; membrane; phospholipid metabolic process; endoplasmic reticulum membrane;
SMPD4	5	glycerophospholipid catabolic process; small molecule metabolic process; lipase activity; phospholipid metabolic process; endoplasmic reticulum membrane;
MBOAT1	5	phosphatidylethanolamine acyl-chain remodeling; glycerophospholipid biosynthetic process; small molecule metabolic process; phospholipid metabolic process; endoplasmic reticulum membrane;
LPCAT1	5	phosphatidylcholine acyl-chain remodeling; glycerophospholipid biosynthetic process; small molecule metabolic process; phospholipid metabolic process; endoplasmic reticulum membrane;
ACHE	5	glycerophospholipid biosynthetic process; small molecule metabolic process; membrane; phospholipid metabolic process; carboxylesterase activity;
LPIN1	5	glycerophospholipid biosynthetic process; small molecule metabolic process; phospholipid metabolic process; endoplasmic reticulum membrane; cytosol;
PLD2	5	glycerophospholipid biosynthetic process; small molecule metabolic process; lipase activity; phospholipid metabolic process; endoplasmic reticulum membrane;
PLD3	5	glycerophospholipid biosynthetic process; small molecule metabolic process; lipase activity; phospholipid metabolic process; endoplasmic reticulum membrane;
PIK3CG	5	small molecule metabolic process; membrane; phospholipid metabolic process; inflammatory response; cytosol;
PRKD1	5	small molecule metabolic process; phospholipid metabolic process; inflammatory response; cytosol; phospholipid binding;
PLCD1	5	lipase activity; intracellular signal transduction; phospholipid metabolic process; cytosol; phospholipid binding;

Genes shared at least 2 KEGG pathways with PLA2G4C (count: 0)

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Region: chr19:48551100..48614109 View in gBrowse