ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	STS
Previous Symbol	ARSC1
Symbol Alias	ARSC
Approved Name	steroid sulfatase (microsomal), isozyme S
Previous Name	steroid sulfatase (microsomal), arylsulfatase C, isozyme S
Name Alias	arylsulfatase C
Location	Xp22.32
Position	chrX:7137472-7272851, +
External Links	HGNC: 11425 Entrez Gene: 412 Ensembl: ENSG00000101846 UCSC: uc004cry.3
No. of Studies	3 (significant: 2; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 3)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Stergiakouli E, 2011	They did not replicate the previously identified association with rs12861247 in this case-control sample	Non-significant
Brookes KJ, 2010	7 SNPs had significant evidence for association, but cannot survive stringent correction for multiple testing; haplotype CGGTTCTGCTGG P-value=0.02, X² =10.13, but did not survive Bonferroni correction	Significant
Brookes KJ, 2008(b)	STS global P-value=0.039; haplotype-specific P-value=0.03, OR=1.52; support the hypothesis that the STS gene is a potential candidate for ADHD susceptibility	Significant

Gene related SNPs (count: 57)

Literature-origin SNPs (count: 15)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs1000900	ChrX:7152113(Fwd)	intron_variant	1(0/1/0)
rs6639786	ChrX:7161475(Fwd)	intron_variant	1(1/0/0)
rs2024159	ChrX:7166212(Fwd)	intron_variant	1(0/1/0)
rs1473666	ChrX:7066051(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant	1(0/1/0)
rs12861247	ChrX:7174199(Fwd)	intron_variant	3(2/1/0)
rs4403552	ChrX:7243304(Fwd)	intron_variant	1(0/1/0)
rs5934769	ChrX:7169518(Fwd)	intron_variant	1(1/0/0)
rs2270112	ChrX:7170925(Fwd)	intron_variant	2(2/0/0)
rs5934740	ChrX:7157652(Fwd)	intron_variant	2(0/2/0)
rs5933863	ChrX:7270694(Fwd)	3_prime_UTR_variant	1(0/1/0)
rs11095437	ChrX:7165491(Fwd)	intron_variant	1(0/1/0)
rs5934770	ChrX:7169546(Fwd)	intron_variant	1(1/0/0)
rs7058445	ChrX:7172508(Fwd)	intron_variant	2(0/2/0)
rs17335568	ChrX:7174813(Fwd)	intron_variant	1(1/0/0)
rs17268988	ChrX:7254481(Fwd)	intron_variant	1(0/1/0)

LD-proxies (count: 42)

rs_ID	Location	Functional Annotation
rs5979315	ChrX:7204036(Fwd)	intron_variant
rs3788889	ChrX:7165191(Fwd)	intron_variant
rs5934700	ChrX:7139497(Fwd)	intron_variant
rs5934915	ChrX:7215336(Fwd)	intron_variant
rs6639783	ChrX:7157128(Fwd)	intron_variant
rs5934917	ChrX:7216751(Fwd)	intron_variant
rs5933779	ChrX:7143665(Fwd)	intron_variant
rs2072326	ChrX:7138066(Fwd)	intron_variant
rs5933826	ChrX:7179088(Fwd)	intron_variant
rs4595309	ChrX:7180530(Fwd)	intron_variant
rs2098072	ChrX:7146353(Fwd)	intron_variant
rs5933793	ChrX:7150497(Fwd)	intron_variant
rs5934881	ChrX:7191186(Fwd)	intron_variant
rs4132409	ChrX:7198069(Fwd)	intron_variant
rs5933830	ChrX:7181079(Fwd)	intron_variant
rs5934850	ChrX:7184615(Fwd)	intron_variant
rs5978404	ChrX:7202513(Fwd)	intron_variant
rs5978405	ChrX:7209427(Fwd)	intron_variant
rs5934904	ChrX:7198469(Fwd)	intron_variant
rs5934907	ChrX:7199917(Fwd)	intron_variant
rs5979331	ChrX:7216341(Fwd)	intron_variant
rs5934918	ChrX:7217969(Fwd)	intron_variant
rs5934913	ChrX:7212277(Fwd)	intron_variant
rs6639811	ChrX:7215803(Fwd)	intron_variant
rs5934937	ChrX:7241082(Fwd)	intron_variant
rs5934914	ChrX:7214805(Fwd)	intron_variant
rs5933846	ChrX:7196593(Fwd)	intron_variant
rs5934958	ChrX:7266199(Fwd)	intron_variant
rs4830673	ChrX:7144530(Fwd)	intron_variant
rs11798506	ChrX:7150017(Fwd)	intron_variant
rs5979338	ChrX:7222219(Fwd)	intron_variant
rs5979364	ChrX:7244205(Fwd)	intron_variant
rs6639825	ChrX:7260656(Fwd)	intron_variant
rs1131289	ChrX:7270996(Fwd)	3_prime_UTR_variant
rs5934842	ChrX:7182283(Fwd)	intron_variant
rs13648	ChrX:7272225(Fwd)	3_prime_UTR_variant
rs5934743	ChrX:7159174(Fwd)	intron_variant
rs5934979	ChrX:7276562(Fwd)	downstream_gene_variant
rs6530079	ChrX:7277081(Fwd)	downstream_gene_variant
rs6639817	ChrX:7225221(Fwd)	intron_variant
rs3923341	ChrX:7218900(Fwd)	intron_variant
rs17268974	ChrX:7236970(Fwd)	intron_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 22)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0046872	metal ion binding	Molecular Function		170
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0044267	cellular protein metabolic process	Biological Process		64
GO:0004773	steryl-sulfatase activity	Molecular Function		1
GO:0005768	endosome	Cellular Component	TAS[2668275]	27
GO:0005764	lysosome	Cellular Component	TAS[2668275]	31
GO:0005886	plasma membrane	Cellular Component	TAS[2668275]	772
GO:0006644	phospholipid metabolic process	Biological Process		59
GO:0006665	sphingolipid metabolic process	Biological Process		16
GO:0006687	glycosphingolipid metabolic process	Biological Process		9
GO:0005783	endoplasmic reticulum	Cellular Component	TAS[2668275]	100
GO:0005788	endoplasmic reticulum lumen	Cellular Component		33
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0005794	Golgi apparatus	Cellular Component	TAS[2668275]	157
GO:0016020	membrane	Cellular Component	TAS[2668275]	139
GO:0016021	integral to membrane	Cellular Component		845
GO:0043231	intracellular membrane-bounded organelle	Cellular Component	TAS[6957717]	62
GO:0043687	post-translational protein modification	Biological Process		37
GO:0006706	steroid catabolic process	Biological Process	TAS[6957717]	1
GO:0007565	female pregnancy	Biological Process		14
GO:0008484	sulfuric ester hydrolase activity	Molecular Function	IDA[15962010]	2
GO:0008544	epidermis development	Biological Process	TAS[9252398]	12

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00140	Steroid hormone biosynthesis	24	Steroid hormones derived from cholesterol are a class of bio...... Steroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 compound, to the first C21 steroid, pregnenolone, which is converted by a bifunctional enzyme complex to the gestagen hormone, progesterone [MD:M00107]. Pregnenolone and progesterone are the starting materials for the three groups of steroids: C21 steroids of glucocorticoids and mineralocorticoids, C19 steroids of androgens, and C18 steroids of estrogens. (i) Progesterone is converted by hydroxylations at carbons 21 and 11 to corticosterone, which is further modified by hydroxylation and oxydoreduction at carbon 18 to yield aldosterone, a mineralcorticoid [MD:M00108]. Cortisol, the main glucocorticoid, is formed from 17alpha-hydroxyprogesterone with 11-deoxycortisol as an intermediate [MD:M00109]. (ii) Male hormone testosterone is formed from pregnenolone by two pathways, delta5 pathway via dehydroepiandrosterone and delta4 pathway via androstenedione [MD:M00110]. The enzyme CYP17A1 is responsible for the 17,20 lyase and 17alpha-hydroxylase activities in respective pathways. (iii) Female hormones estrone and estradiol are formed from testosterone and 4-androstene-3,17-dione by oxidative removal of the C19 methyl group and subsequent aromatization of ring A [MD:M00111]. In addition to these three groups, recent studies show that there is another group, termed neurosteroids, synthesized in the brain rather than the peripheral endocrine gland. More...

Genes shared at least 5 GO terms with STS (count: 36)

Gene Symbol	Pathway Count	Pathway List
SMPD4	9	metal ion binding; small molecule metabolic process; phospholipid metabolic process; sphingolipid metabolic process; glycosphingolipid metabolic process; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; integral to membrane;
ARSJ	8	metal ion binding; small molecule metabolic process; cellular protein metabolic process; phospholipid metabolic process; sphingolipid metabolic process; glycosphingolipid metabolic process; endoplasmic reticulum lumen; post-translational protein modification;
SUMF1	8	metal ion binding; small molecule metabolic process; cellular protein metabolic process; phospholipid metabolic process; sphingolipid metabolic process; glycosphingolipid metabolic process; endoplasmic reticulum lumen; post-translational protein modification;
ENPP7	8	small molecule metabolic process; plasma membrane; phospholipid metabolic process; sphingolipid metabolic process; glycosphingolipid metabolic process; Golgi apparatus; membrane; integral to membrane;
UGCG	7	small molecule metabolic process; phospholipid metabolic process; sphingolipid metabolic process; glycosphingolipid metabolic process; membrane; integral to membrane; epidermis development;
PRKD1	6	metal ion binding; small molecule metabolic process; plasma membrane; phospholipid metabolic process; sphingolipid metabolic process; Golgi apparatus;
SMPD2	6	metal ion binding; small molecule metabolic process; plasma membrane; phospholipid metabolic process; sphingolipid metabolic process; glycosphingolipid metabolic process;
ACHE	6	small molecule metabolic process; plasma membrane; phospholipid metabolic process; endoplasmic reticulum lumen; Golgi apparatus; membrane;
LPCAT1	6	small molecule metabolic process; phospholipid metabolic process; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; integral to membrane;
PLD1	6	small molecule metabolic process; endosome; phospholipid metabolic process; endoplasmic reticulum membrane; Golgi apparatus; membrane;
DPAGT1	6	cellular protein metabolic process; endoplasmic reticulum membrane; membrane; integral to membrane; intracellular membrane-bounded organelle; post-translational protein modification;
ADCY4	5	metal ion binding; small molecule metabolic process; plasma membrane; membrane; integral to membrane;
B4GALT4	5	metal ion binding; small molecule metabolic process; cellular protein metabolic process; integral to membrane; post-translational protein modification;
B4GALT6	5	metal ion binding; small molecule metabolic process; cellular protein metabolic process; integral to membrane; post-translational protein modification;
FURIN	5	metal ion binding; cellular protein metabolic process; plasma membrane; integral to membrane; post-translational protein modification;
LMAN1	5	metal ion binding; cellular protein metabolic process; endoplasmic reticulum membrane; integral to membrane; post-translational protein modification;
CDIPT	5	small molecule metabolic process; plasma membrane; phospholipid metabolic process; endoplasmic reticulum membrane; integral to membrane;
COMT	5	small molecule metabolic process; plasma membrane; integral to membrane; intracellular membrane-bounded organelle; female pregnancy;
CTGF	5	small molecule metabolic process; plasma membrane; Golgi apparatus; intracellular membrane-bounded organelle; epidermis development;
CUBN	5	small molecule metabolic process; plasma membrane; endoplasmic reticulum; Golgi apparatus; membrane;
DGAT2	5	small molecule metabolic process; phospholipid metabolic process; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane;
FADS1	5	small molecule metabolic process; endoplasmic reticulum membrane; membrane; integral to membrane; intracellular membrane-bounded organelle;
NEU3	5	small molecule metabolic process; plasma membrane; phospholipid metabolic process; sphingolipid metabolic process; glycosphingolipid metabolic process;
PNPLA3	5	small molecule metabolic process; phospholipid metabolic process; endoplasmic reticulum membrane; membrane; integral to membrane;
PNPLA8	5	small molecule metabolic process; phospholipid metabolic process; endoplasmic reticulum membrane; membrane; integral to membrane;
SPTLC1	5	small molecule metabolic process; phospholipid metabolic process; sphingolipid metabolic process; endoplasmic reticulum membrane; integral to membrane;
SPTLC3	5	small molecule metabolic process; phospholipid metabolic process; sphingolipid metabolic process; endoplasmic reticulum membrane; integral to membrane;
ALG2	5	cellular protein metabolic process; endoplasmic reticulum membrane; membrane; integral to membrane; post-translational protein modification;
CANX	5	cellular protein metabolic process; endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum membrane; post-translational protein modification;
MAN1A1	5	cellular protein metabolic process; endoplasmic reticulum; membrane; integral to membrane; post-translational protein modification;
PIGL	5	cellular protein metabolic process; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; post-translational protein modification;
SORT1	5	endosome; plasma membrane; endoplasmic reticulum membrane; Golgi apparatus; integral to membrane;
UNC93B1	5	endosome; lysosome; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane;
PTCH1	5	plasma membrane; Golgi apparatus; integral to membrane; intracellular membrane-bounded organelle; epidermis development;
TMED10	5	plasma membrane; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; integral to membrane;
TMED2	5	endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; integral to membrane; intracellular membrane-bounded organelle;

Genes shared at least 2 KEGG pathways with STS (count: 0)

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Region: chrX:7137472..7272851 View in gBrowse