ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs7058445 dbSNP Ensembl
Location	ChrX:7172508(Fwd)
Variant Alleles	T/C
Ancestral Allele	T
Functional Annotation	intron_variant.
Consequence to Transcript	intron_variant(ENST00000217961)
No. of Studies	2 (significant: 0; non-significant: 2; trend: 0)
Source	Literature-origin

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Brookes KJ, 2010			TDT P-value=0.68, OR=1.14 TDT P-value=0.68, OR=1.14	no significant association no significant association	Non-significant
Brookes KJ, 2008(b)			TDT P-value=0.32, OR=1.2 TDT P-value=0.32, OR=1.2	not significantly associated not significantly associated	Non-significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
STS	steroid sulfatase (microsomal), isozyme S	Xp22.32	3(2/1/0)

Genes from other sources (count: 0)

SNPs in LD with rs7058445 (count: 39) View in gBrowse (chrX:6984240..7315751 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 3)

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs2024159	intron_variant	1(0/1/0)	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 0.965[GIH]; 1.0[JPT]; 1.0[LWK]; 0.942[MEX]; 1.0[MKK]; 1.0[TSI]; 1.0[YRI]
rs11095437	intron_variant	1(0/1/0)	0.88[CEU]; 1.0[GIH]; 0.942[MEX]; 0.906[TSI]
rs1000900	intron_variant	1(0/1/0)	1.0[CEU]; 1.0[CHB]; 0.959[CHD]; 1.0[GIH]; 1.0[JPT]; 0.941[MEX]; 1.0[TSI]

LD-proxies (count: 36)

rs_ID	Functional Annotation	r²[population]
rs1131289	3_prime_UTR_variant	1.0[CEU]; 0.822[CHB]; 0.928[JPT]
rs5979338	intron_variant	1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 0.965[GIH]; 1.0[JPT]; 0.887[MEX]; 0.906[TSI]
rs13648	3_prime_UTR_variant	1.0[CEU]; 0.822[CHB]; 0.928[JPT]; 0.827[MEX]
rs6639825	intron_variant	1.0[CEU]; 0.822[CHB]; 0.863[GIH]; 0.928[JPT]; 0.853[TSI]
rs4830735		1.0[CEU]; 0.822[CHB]; 0.928[JPT]; 0.862[TSI]
rs5934979	downstream_gene_variant	1.0[CEU]; 0.898[GIH]; 0.863[JPT]; 0.853[TSI]
rs2379207	synonymous_variant	0.88[CEU]; 0.935[CHB]; 1.0[CHD]; 0.802[GIH]; 0.928[JPT]; 1.0[TSI]
rs12556704	intron_variant	1.0[ASW]; 0.88[CEU]; 0.935[CHB]; 1.0[CHD]; 0.802[GIH]; 0.928[JPT]; 0.868[LWK]; 0.942[MEX]; 0.977[MKK]; 1.0[TSI]; 0.904[YRI]
rs5978432		1.0[CEU]; 0.822[CHB]; 0.863[JPT]; 0.83[MEX]
rs4830399	intron_variant; nc_transcript_variant	0.879[CEU]; 0.857[CHB]; 0.887[JPT]; 1.0[YRI]
rs11798506	intron_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 1.0[YRI]
rs12557020	intron_variant	0.862[CEU]; 0.911[CHB]; 0.912[JPT]
rs1465067	intron_variant; nc_transcript_variant	0.815[ASW]; 0.88[CEU]; 0.935[CHB]; 1.0[CHD]; 0.802[GIH]; 0.928[JPT]; 0.942[MEX]; 1.0[MKK]; 1.0[TSI]; 1.0[YRI]
rs12689752	intron_variant	1.0[ASW]; 0.88[CEU]; 0.935[CHB]; 1.0[CHD]; 0.802[GIH]; 0.928[JPT]; 0.933[LWK]; 0.942[MEX]; 1.0[MKK]; 1.0[TSI]; 1.0[YRI]
rs1131197	intron_variant; missense_variant; nc_transcript_variant; non_coding_exon_variant	0.88[CEU]; 0.935[CHB]; 1.0[CHD]; 0.802[GIH]; 0.928[JPT]; 0.942[MEX]; 1.0[TSI]
rs4830590	downstream_gene_variant; intron_variant	1.0[ASW]; 0.875[CEU]; 0.935[CHB]; 1.0[CHD]; 0.802[GIH]; 0.928[JPT]; 0.942[MEX]; 1.0[MKK]; 1.0[TSI]; 1.0[YRI]
rs5979364	intron_variant	0.872[CEU]; 0.931[GIH]; 0.83[MEX]
rs5933846	intron_variant	1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 0.942[MEX]; 0.952[TSI]
rs4131206		1.0[CEU]; 0.822[CHB]; 0.898[GIH]; 0.928[JPT]; 0.83[MEX]; 0.859[TSI]
rs5935121		1.0[CEU]; 0.822[CHB]; 0.898[GIH]; 0.928[JPT]; 0.899[TSI]
rs5934958	intron_variant	1.0[CEU]; 0.822[CHB]; 0.898[GIH]; 0.928[JPT]; 0.884[MEX]; 0.815[TSI]
rs6530084		0.939[CEU]; 0.822[CHB]; 0.863[JPT]
rs11095393		0.932[CEU]
rs12687927		0.939[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 0.942[MEX]; 1.0[TSI]
rs5935116		0.88[CEU]
rs727519		1.0[CEU]; 1.0[CHB]; 1.0[JPT]
rs4830673	intron_variant	1.0[CEU]; 1.0[CHB]; 0.957[CHD]; 1.0[JPT]
rs17326009	downstream_gene_variant; intron_variant	1.0[ASW]; 0.88[CEU]; 0.935[CHB]; 0.916[CHD]; 0.802[GIH]; 0.928[JPT]; 0.868[LWK]; 0.942[MEX]; 1.0[MKK]; 1.0[TSI]; 0.904[YRI]
rs12859783		1.0[CEU]; 0.897[GIH]; 0.887[MEX]; 0.905[TSI]
rs12558888	intron_variant	0.866[CEU]; 0.923[CHB]; 0.905[JPT]; 0.897[YRI]
rs5934914	intron_variant	1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 0.931[GIH]; 1.0[JPT]; 0.887[MEX]; 0.952[TSI]
rs1029748		1.0[CEU]; 1.0[CHB]; 1.0[JPT]
rs1125438	intron_variant; nc_transcript_variant	1.0[ASW]; 0.88[CEU]; 1.0[CHB]; 1.0[CHD]; 0.802[GIH]; 0.928[JPT]; 0.933[LWK]; 0.942[MEX]; 1.0[MKK]; 1.0[TSI]; 1.0[YRI]
rs6530079	downstream_gene_variant	1.0[CEU]; 0.894[GIH]; 0.863[JPT]; 0.884[MEX]; 0.803[TSI]
rs941172	downstream_gene_variant; upstream_gene_variant	0.88[CEU]; 0.802[GIH]; 0.94[MEX]; 0.899[TSI]
rs5979400		0.822[CHB]; 0.928[JPT]