ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TMED2
Symbol Alias	RNP24, P24A
Approved Name	transmembrane emp24 domain trafficking protein 2
Location	12q24.31
Position	chr12:124069076-124082688, +
External Links	HGNC: 16996 Entrez Gene: 10959 Ensembl: ENSG00000086598 UCSC: uc001ufg.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_26	chr12:122465458-124605386 (NCBI36 / hg18)	2139929	12q24.31-12q24.32	dup

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 28)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 28)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0072661	protein targeting to plasma membrane	Biological Process		5
GO:0042589	zymogen granule membrane	Cellular Component		4
GO:0043231	intracellular membrane-bounded organelle	Cellular Component		62
GO:0048205	COPI coating of Golgi vesicle	Biological Process	TAS[10761932]	8
GO:0048208	COPII vesicle coating	Biological Process		2
GO:0001892	embryonic placenta development	Biological Process		4
GO:0001893	maternal placenta development	Biological Process		2
GO:0001843	neural tube closure	Biological Process		10
GO:0005783	endoplasmic reticulum	Cellular Component	IDA[12237308]	100
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0001947	heart looping	Biological Process		5
GO:0005515	protein binding	Molecular Function		910
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	Cellular Component		10
GO:0032580	Golgi cisterna membrane	Cellular Component		18
GO:0032525	somite rostral/caudal axis specification	Biological Process		2
GO:0030663	COPI-coated vesicle membrane	Cellular Component		1
GO:0036342	post-anal tail morphogenesis	Biological Process		3
GO:0035459	cargo loading into vesicle	Biological Process		2
GO:0035264	multicellular organism growth	Biological Process		10
GO:0034260	negative regulation of GTPase activity	Biological Process	IDA[10761932]	4
GO:0006888	ER to Golgi vesicle-mediated transport	Biological Process		24
GO:0006886	intracellular protein transport	Biological Process		43
GO:0005794	Golgi apparatus	Cellular Component	IDA[12237308]	157
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	Cellular Component	IDA[12237308]	17
GO:0030137	COPI-coated vesicle	Cellular Component		4
GO:0016021	integral to membrane	Cellular Component		845
GO:0010628	positive regulation of gene expression	Biological Process		28
GO:0007030	Golgi organization	Biological Process	IMP[17693410]	11

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with TMED2 (count: 14)

Gene Symbol	Pathway Count	Pathway List
TMED10	15	zymogen granule membrane; COPI coating of Golgi vesicle; COPII vesicle coating; endoplasmic reticulum; endoplasmic reticulum membrane; protein binding; endoplasmic reticulum-Golgi intermediate compartment membrane; cargo loading into vesicle; ER to Golgi vesicle-mediated transport; intracellular protein transport; Golgi apparatus; endoplasmic reticulum-Golgi intermediate compartment; COPI-coated vesicle; integral to membrane; Golgi organization;
LMAN1	7	endoplasmic reticulum membrane; protein binding; endoplasmic reticulum-Golgi intermediate compartment membrane; ER to Golgi vesicle-mediated transport; endoplasmic reticulum-Golgi intermediate compartment; integral to membrane; Golgi organization;
PTCH1	6	protein targeting to plasma membrane; intracellular membrane-bounded organelle; neural tube closure; protein binding; Golgi apparatus; integral to membrane;
YIF1A	6	intracellular membrane-bounded organelle; endoplasmic reticulum membrane; protein binding; Golgi apparatus; endoplasmic reticulum-Golgi intermediate compartment; integral to membrane;
STX18	6	endoplasmic reticulum; endoplasmic reticulum membrane; protein binding; ER to Golgi vesicle-mediated transport; intracellular protein transport; integral to membrane;
STX5	6	endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment membrane; ER to Golgi vesicle-mediated transport; intracellular protein transport; Golgi apparatus; integral to membrane;
ERGIC1	6	endoplasmic reticulum membrane; protein binding; endoplasmic reticulum-Golgi intermediate compartment membrane; ER to Golgi vesicle-mediated transport; endoplasmic reticulum-Golgi intermediate compartment; integral to membrane;
SEC22B	6	endoplasmic reticulum membrane; protein binding; endoplasmic reticulum-Golgi intermediate compartment membrane; ER to Golgi vesicle-mediated transport; endoplasmic reticulum-Golgi intermediate compartment; integral to membrane;
LTC4S	5	intracellular membrane-bounded organelle; endoplasmic reticulum; endoplasmic reticulum membrane; protein binding; integral to membrane;
STS	5	intracellular membrane-bounded organelle; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; integral to membrane;
STX16	5	intracellular membrane-bounded organelle; protein binding; intracellular protein transport; Golgi apparatus; integral to membrane;
ATL3	5	endoplasmic reticulum; endoplasmic reticulum membrane; ER to Golgi vesicle-mediated transport; integral to membrane; Golgi organization;
USE1	5	endoplasmic reticulum; endoplasmic reticulum membrane; protein binding; ER to Golgi vesicle-mediated transport; integral to membrane;
COG3	5	protein binding; Golgi cisterna membrane; ER to Golgi vesicle-mediated transport; intracellular protein transport; Golgi apparatus;

Genes shared at least 2 KEGG pathways with TMED2 (count: 0)

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Region: chr12:124069076..124082688 View in gBrowse