ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	DPAGT1
Previous Symbol	DPAGT2, DPAGT
Symbol Alias	GPT, D11S366, DGPT, ALG7, CDG-Ij
Approved Name	dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
Location	11q23.3
Position	chr11:118967213-118979041, -
External Links	HGNC: 2995 Entrez Gene: 1798 Ensembl: ENSG00000172269 UCSC: uc001pvi.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006487	protein N-linked glycosylation	Biological Process	IMP[19549906]	2
GO:0006488	dolichol-linked oligosaccharide biosynthetic process	Biological Process		8
GO:0008963	phospho-N-acetylmuramoyl-pentapeptide-transferase activity	Molecular Function		1
GO:0016020	membrane	Cellular Component	IDA[8179616]	139
GO:0003975	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity	Molecular Function	IDA[8179616]; IMP[12872255]	1
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0006047	UDP-N-acetylglucosamine metabolic process	Biological Process		1
GO:0051259	protein oligomerization	Biological Process		8
GO:0044267	cellular protein metabolic process	Biological Process		64
GO:0043687	post-translational protein modification	Biological Process		37
GO:0043231	intracellular membrane-bounded organelle	Cellular Component	IDA[12872255]	62
GO:0030176	integral to endoplasmic reticulum membrane	Cellular Component	NAS[12872255]	14
GO:0019408	dolichol biosynthetic process	Biological Process	IDA[8179616]	1
GO:0018279	protein N-linked glycosylation via asparagine	Biological Process		24
GO:0016757	transferase activity, transferring glycosyl groups	Molecular Function		1
GO:0016021	integral to membrane	Cellular Component		845

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00510	N-Glycan biosynthesis	11	N-glycans or asparagine-linked glycans are major constituent...... N-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glycosidic bond, GlcNAc b1- Asn. Biosynthesis of N-glycans begins on the cytoplasmic face of the ER membrane with the transferase reaction of UDP-GlcNAc and the lipid-like precursor P-Dol (dolichol phosphate) to generate GlcNAc a1- PP-Dol. After sequential addition of monosaccharides by ALG glycosyltransferases [MD:M00055], the N-glycan precursor is attached by the OST (oligosaccharyltransferase) complex to the polypeptide chain that is being synthesized and translocated through the ER membrane. The protein-bound N-glycan precursor is subsequently trimmed, extended, and modified in the ER and Golgi by a complex series of reactions catalyzed by membrane-bound glycosidases and glycosyltransferases. N-glycans thus synthesized are classified into three types: high-mannose type, complex type, and hybrid type. Defects in N-glycan biosynthesis lead to a variety of human diseases known as congenital disorders of glycosylation [DS:H00118 H00119]. More...
hsa01100	Metabolic pathways	237

Genes shared at least 5 GO terms with DPAGT1 (count: 8)

Gene Symbol	Pathway Count	Pathway List
ALG8	7	protein N-linked glycosylation; dolichol-linked oligosaccharide biosynthetic process; endoplasmic reticulum membrane; cellular protein metabolic process; post-translational protein modification; protein N-linked glycosylation via asparagine; integral to membrane;
ALG2	7	dolichol-linked oligosaccharide biosynthetic process; membrane; endoplasmic reticulum membrane; cellular protein metabolic process; post-translational protein modification; protein N-linked glycosylation via asparagine; integral to membrane;
ALG10	6	dolichol-linked oligosaccharide biosynthetic process; endoplasmic reticulum membrane; cellular protein metabolic process; post-translational protein modification; protein N-linked glycosylation via asparagine; integral to membrane;
ALG9	6	dolichol-linked oligosaccharide biosynthetic process; endoplasmic reticulum membrane; cellular protein metabolic process; post-translational protein modification; protein N-linked glycosylation via asparagine; integral to membrane;
STS	6	membrane; endoplasmic reticulum membrane; cellular protein metabolic process; post-translational protein modification; intracellular membrane-bounded organelle; integral to membrane;
MAN1A1	5	membrane; cellular protein metabolic process; post-translational protein modification; protein N-linked glycosylation via asparagine; integral to membrane;
LMAN1	5	endoplasmic reticulum membrane; cellular protein metabolic process; post-translational protein modification; protein N-linked glycosylation via asparagine; integral to membrane;
STT3A	5	endoplasmic reticulum membrane; cellular protein metabolic process; post-translational protein modification; protein N-linked glycosylation via asparagine; integral to membrane;

Genes shared at least 2 KEGG pathways with DPAGT1 (count: 10)

Gene Symbol	Pathway Count	Pathway List
ALG10	2	N-Glycan biosynthesis; Metabolic pathways;
ALG2	2	N-Glycan biosynthesis; Metabolic pathways;
ALG8	2	N-Glycan biosynthesis; Metabolic pathways;
ALG9	2	N-Glycan biosynthesis; Metabolic pathways;
GANAB	2	N-Glycan biosynthesis; Metabolic pathways;
MAN1A1	2	N-Glycan biosynthesis; Metabolic pathways;
MAN2A2	2	N-Glycan biosynthesis; Metabolic pathways;
MGAT1	2	N-Glycan biosynthesis; Metabolic pathways;
MGAT4B	2	N-Glycan biosynthesis; Metabolic pathways;
STT3A	2	N-Glycan biosynthesis; Metabolic pathways;

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Region: chr11:118967213..118979041 View in gBrowse