ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ALG2
Symbol Alias	CDGIi, FLJ14511, hALPG2, NET38
Approved Name	asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae)
Previous Name	asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase)
Location	9q31.1
Position	chr9:101978707-101984246, -
External Links	HGNC: 23159 Entrez Gene: 85365 Ensembl: ENSG00000119523 UCSC: uc004azf.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q22	chr9:90400000-102600000	3 (1/1/1)

Gene related GO terms (count: 19)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051592	response to calcium ion	Biological Process	IDA[17196169]	9
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IDA[17196169]	87
GO:0048306	calcium-dependent protein binding	Molecular Function	IMP[14999017]; IPI[16957052]	5
GO:0047485	protein N-terminus binding	Molecular Function	IPI[12445460]	23
GO:0046982	protein heterodimerization activity	Molecular Function	IPI[11278427]	68
GO:0044267	cellular protein metabolic process	Biological Process		64
GO:0043687	post-translational protein modification	Biological Process		37
GO:0043495	protein anchor	Molecular Function	IMP[16957052]	1
GO:0033577	protein glycosylation in endoplasmic reticulum	Biological Process	IGI[12684507]	1
GO:0018279	protein N-linked glycosylation via asparagine	Biological Process		24
GO:0016021	integral to membrane	Cellular Component		845
GO:0016020	membrane	Cellular Component	IDA[16996505]	139
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0006488	dolichol-linked oligosaccharide biosynthetic process	Biological Process	IGI[12684507]	8
GO:0005634	nucleus	Cellular Component	IDA[17196169]	770
GO:0005737	cytoplasm	Cellular Component	IDA[17196169]	690
GO:0004378	GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity	Molecular Function		1
GO:0005515	protein binding	Molecular Function	IPI[11883939]	910
GO:0000033	alpha-1,3-mannosyltransferase activity	Molecular Function	IDA[12684507]	2

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00510	N-Glycan biosynthesis	11	N-glycans or asparagine-linked glycans are major constituent...... N-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glycosidic bond, GlcNAc b1- Asn. Biosynthesis of N-glycans begins on the cytoplasmic face of the ER membrane with the transferase reaction of UDP-GlcNAc and the lipid-like precursor P-Dol (dolichol phosphate) to generate GlcNAc a1- PP-Dol. After sequential addition of monosaccharides by ALG glycosyltransferases [MD:M00055], the N-glycan precursor is attached by the OST (oligosaccharyltransferase) complex to the polypeptide chain that is being synthesized and translocated through the ER membrane. The protein-bound N-glycan precursor is subsequently trimmed, extended, and modified in the ER and Golgi by a complex series of reactions catalyzed by membrane-bound glycosidases and glycosyltransferases. N-glycans thus synthesized are classified into three types: high-mannose type, complex type, and hybrid type. Defects in N-glycan biosynthesis lead to a variety of human diseases known as congenital disorders of glycosylation [DS:H00118 H00119]. More...
hsa01100	Metabolic pathways	237

Genes shared at least 5 GO terms with ALG2 (count: 14)

Gene Symbol	Pathway Count	Pathway List
ALG8	7	cellular protein metabolic process; post-translational protein modification; protein N-linked glycosylation via asparagine; integral to membrane; endoplasmic reticulum membrane; dolichol-linked oligosaccharide biosynthetic process; alpha-1,3-mannosyltransferase activity;
DPAGT1	7	cellular protein metabolic process; post-translational protein modification; protein N-linked glycosylation via asparagine; integral to membrane; membrane; endoplasmic reticulum membrane; dolichol-linked oligosaccharide biosynthetic process;
ALG10	6	cellular protein metabolic process; post-translational protein modification; protein N-linked glycosylation via asparagine; integral to membrane; endoplasmic reticulum membrane; dolichol-linked oligosaccharide biosynthetic process;
ALG9	6	cellular protein metabolic process; post-translational protein modification; protein N-linked glycosylation via asparagine; integral to membrane; endoplasmic reticulum membrane; dolichol-linked oligosaccharide biosynthetic process;
LMAN1	6	cellular protein metabolic process; post-translational protein modification; protein N-linked glycosylation via asparagine; integral to membrane; endoplasmic reticulum membrane; protein binding;
STT3A	6	cellular protein metabolic process; post-translational protein modification; protein N-linked glycosylation via asparagine; integral to membrane; endoplasmic reticulum membrane; protein binding;
ERBB2	5	perinuclear region of cytoplasm; protein heterodimerization activity; integral to membrane; nucleus; protein binding;
SNCA	5	perinuclear region of cytoplasm; protein N-terminus binding; nucleus; cytoplasm; protein binding;
TYR	5	perinuclear region of cytoplasm; protein heterodimerization activity; integral to membrane; cytoplasm; protein binding;
STX1A	5	calcium-dependent protein binding; protein N-terminus binding; protein heterodimerization activity; integral to membrane; protein binding;
CANX	5	cellular protein metabolic process; post-translational protein modification; protein N-linked glycosylation via asparagine; endoplasmic reticulum membrane; protein binding;
MAN1A1	5	cellular protein metabolic process; post-translational protein modification; protein N-linked glycosylation via asparagine; integral to membrane; membrane;
STS	5	cellular protein metabolic process; post-translational protein modification; integral to membrane; membrane; endoplasmic reticulum membrane;
SYVN1	5	protein N-linked glycosylation via asparagine; integral to membrane; endoplasmic reticulum membrane; nucleus; protein binding;

Genes shared at least 2 KEGG pathways with ALG2 (count: 10)

Gene Symbol	Pathway Count	Pathway List
ALG10	2	N-Glycan biosynthesis; Metabolic pathways;
ALG8	2	N-Glycan biosynthesis; Metabolic pathways;
ALG9	2	N-Glycan biosynthesis; Metabolic pathways;
DPAGT1	2	N-Glycan biosynthesis; Metabolic pathways;
GANAB	2	N-Glycan biosynthesis; Metabolic pathways;
MAN1A1	2	N-Glycan biosynthesis; Metabolic pathways;
MAN2A2	2	N-Glycan biosynthesis; Metabolic pathways;
MGAT1	2	N-Glycan biosynthesis; Metabolic pathways;
MGAT4B	2	N-Glycan biosynthesis; Metabolic pathways;
STT3A	2	N-Glycan biosynthesis; Metabolic pathways;

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Region: chr9:101978707..101984246 View in gBrowse