Gene Report
Basic Info
Approved Symbol |
PIGL
|
Approved Name |
phosphatidylinositol glycan anchor biosynthesis, class L |
Previous Name |
phosphatidylinositol glycan, class L |
Name Alias |
N-acetylglucosaminylphosphatidylinositol deacetylase |
Location |
17p12-p11.2 |
Position |
chr17:16120509-16229573, + |
External Links |
HGNC: 8966
Entrez Gene: 9487
Ensembl: ENSG00000108474
UCSC: uc002gpv.2
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by significant region |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 1)
Gene related GO terms (count: 9)
Gene related KEGG pathways (count: 2)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa01100 |
Metabolic pathways |
237 |
|
hsa00563 |
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis |
4 |
Cell surface proteins can be attached to the cell membrane v......
Cell surface proteins can be attached to the cell membrane via the glycolipid structure called glycosylphosphatidylinositol (GPI) anchor. Hundreds of GPI-anchored proteins have been identified in many eukaryotes ranging from protozoa and fungi to mammals. All protein-linked GPI anchors share a common core structure, characterized by the substructure Man (a1-4) GlcN (a1-6) myo-inositol-1P-lipid. Biosynthesis of GPI anchors proceeds in three stages: (i) preassembly of a GPI precursor in the ER membrane, (ii) attachment of the GPI to the C-terminus of a newly synthesized protein in the lumen of the ER, and (iii) lipid remodeling and/or carbohydrate side-chain modifications in the ER and the Golgi. Defects of GPI anchor biosynthesis gene result in a genetic disorder, paroxysmal nocturnal hemoglobinuria.
More...
|
Genes shared at least 5 GO terms with PIGL (count: 4)
Genes shared at least 2 KEGG pathways with PIGL (count: 3)
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