ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PLCD4
Approved Name	phospholipase C, delta 4
Location	2q35
Position	chr2:219472488-219501907, +
External Links	HGNC: 9062 Entrez Gene: 84812 Ensembl: ENSG00000115556 UCSC: uc002vij.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2q35	chr2:215300000-221500000	1 (1/0/0)

Gene related GO terms (count: 10)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 10)

ID	Name	Type	No. of Genes in ADHDgene
GO:0035556	intracellular signal transduction	Biological Process	44
GO:0016042	lipid catabolic process	Biological Process	32
GO:0016020	membrane	Cellular Component	139
GO:0007340	acrosome reaction	Biological Process	1
GO:0005783	endoplasmic reticulum	Cellular Component	100
GO:0005634	nucleus	Cellular Component	770
GO:0005543	phospholipid binding	Molecular Function	61
GO:0005509	calcium ion binding	Molecular Function	124
GO:0004435	phosphatidylinositol phospholipase C activity	Molecular Function	20
GO:0004871	signal transducer activity	Molecular Function	49

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00562	Inositol phosphate metabolism	14
hsa04070	Phosphatidylinositol signaling system	19
hsa04020	Calcium signaling pathway	63	Ca2+ that enters the cell from the outside is a principal so...... Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs). More...

Genes shared at least 5 GO terms with PLCD4 (count: 5)

Gene Symbol	Pathway Count	Pathway List
PLCB3	6	intracellular signal transduction; lipid catabolic process; membrane; calcium ion binding; phosphatidylinositol phospholipase C activity; signal transducer activity;
PLCD1	6	intracellular signal transduction; lipid catabolic process; phospholipid binding; calcium ion binding; phosphatidylinositol phospholipase C activity; signal transducer activity;
PLCB2	5	intracellular signal transduction; lipid catabolic process; calcium ion binding; phosphatidylinositol phospholipase C activity; signal transducer activity;
PLCL1	5	intracellular signal transduction; phospholipid binding; calcium ion binding; phosphatidylinositol phospholipase C activity; signal transducer activity;
PLCH1	5	lipid catabolic process; phospholipid binding; calcium ion binding; phosphatidylinositol phospholipase C activity; signal transducer activity;

Genes shared at least 2 KEGG pathways with PLCD4 (count: 18)

Gene Symbol	Pathway Count	Pathway List
PLCB2	4	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system; Calcium signaling pathway;
PLCB3	4	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system; Calcium signaling pathway;
PLCD1	4	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system; Calcium signaling pathway;
PLCE1	4	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system; Calcium signaling pathway;
PLCG2	4	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system; Calcium signaling pathway;
CDIPT	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
INPP5A	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
INPPL1	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
IPPK	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PI4K2B	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PI4KA	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PIK3C3	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
DGKH	2	Metabolic pathways; Phosphatidylinositol signaling system;
NOS1	2	Metabolic pathways; Calcium signaling pathway;
PIK3CG	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;
ITPR1	2	Phosphatidylinositol signaling system; Calcium signaling pathway;
ITPR2	2	Phosphatidylinositol signaling system; Calcium signaling pathway;
PRKCB	2	Phosphatidylinositol signaling system; Calcium signaling pathway;

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Region: chr2:219472488..219501907 View in gBrowse