ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0005085
Name guanyl-nucleotide exchange factor activity
Type molecular function
No. of Genes in ADHDgene  17
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 17)

Literature-origin genes (count: 3)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
TRIO trio Rho guanine nucleotide exchange factor 5p14-p15.1 1(0/0/1) TAS[8643598]
TIAM2 T-cell lymphoma invasion and metastasis 2 6q25 1(0/0/1) TAS[10512681]
NET1 neuroepithelial cell transforming 1 10p15 1(1/0/0) TAS[8649828]

Genes from other sources Help (count: 14)

Approved Symbol Approved Name Source Evidence[PMID]
GAPVD1 GTPase activating protein and VPS9 domains 1 Mapped by significant region IMP[16410077]
RASGEF1C RasGEF domain family, member 1C Mapped by CNV IEA
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa Mapped by CNV IDA[11323413]
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 Mapped by CNV; Mapped by significant region IMP[17599059]
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 Mapped by significant region NAS[9949213]
RGL4 ral guanine nucleotide dissociation stimulator-like 4 Mapped by CNV IEA
PLCE1 phospholipase C, epsilon 1 Mapped by PBA pathway TAS[11022047]
SPATA13 spermatogenesis associated 13 Mapped by Literature SNP; Mapped by CNV IDA[19934221]; IMP[17599059]
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) Mapped by significant region TAS[9789079]
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Mapped by significant region IDA
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 Mapped by significant region NAS[10747847]
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 Mapped by significant region IDA[12071859]
FGD3 FYVE, RhoGEF and PH domain containing 3 Mapped by significant region ISS
DOCK8 dedicator of cytokinesis 8 Mapped by CNV IEA