ADHDgene Database

Gene Report

Basic Info

Approved Symbol	LAMTOR1
Previous Symbol	C11orf59
Symbol Alias	FLJ20625, p18, p27RF-Rho, Pdro, Ragulator1
Approved Name	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Previous Name	chromosome 11 open reading frame 59
Name Alias	p27kip1 releasing factor from RhoA, "protein associated with DRMs and endosomes"
Location	11q13.4
Position	chr11:71808338-71814433, -
External Links	HGNC: 26068 Entrez Gene: 55004 Ensembl: ENSG00000149357 UCSC: uc009ytb.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 25)

ID	Name	Type	No. of Genes in ADHDgene
GO:0045121	membrane raft	Cellular Component	22
GO:0060620	regulation of cholesterol import	Biological Process	1
GO:0043231	intracellular membrane-bounded organelle	Cellular Component	62
GO:0043410	positive regulation of MAPK cascade	Biological Process	17
GO:0071230	cellular response to amino acid stimulus	Biological Process	5
GO:0071986	Ragulator complex	Cellular Component	1
GO:0007040	lysosome organization	Biological Process	7
GO:0007032	endosome organization	Biological Process	7
GO:0010874	regulation of cholesterol efflux	Biological Process	1
GO:0010872	regulation of cholesterol esterification	Biological Process	1
GO:0005765	lysosomal membrane	Cellular Component	17
GO:0005764	lysosome	Cellular Component	31
GO:0005886	plasma membrane	Cellular Component	772
GO:0005794	Golgi apparatus	Cellular Component	157
GO:0032947	protein complex scaffold	Molecular Function	5
GO:0032439	endosome localization	Biological Process	1
GO:0042632	cholesterol homeostasis	Biological Process	18
GO:0034613	cellular protein localization	Biological Process	9
GO:0031902	late endosome membrane	Cellular Component	15
GO:0016049	cell growth	Biological Process	11
GO:0032418	lysosome localization	Biological Process	2
GO:0032008	positive regulation of TOR signaling cascade	Biological Process	5
GO:0001919	regulation of receptor recycling	Biological Process	2
GO:0005085	guanyl-nucleotide exchange factor activity	Molecular Function	17
GO:0005515	protein binding	Molecular Function	910

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with LAMTOR1 (count: 6)

Gene Symbol	Pathway Count	Pathway List
NPC1	7	membrane raft; lysosomal membrane; lysosome; Golgi apparatus; cholesterol homeostasis; late endosome membrane; protein binding;
ABCA1	6	membrane raft; lysosome organization; plasma membrane; Golgi apparatus; cholesterol homeostasis; protein binding;
CAV3	6	membrane raft; plasma membrane; protein complex scaffold; cholesterol homeostasis; cell growth; protein binding;
GJA1	5	membrane raft; lysosome; plasma membrane; Golgi apparatus; protein binding;
RPTOR	5	cellular response to amino acid stimulus; lysosome; cell growth; positive regulation of TOR signaling cascade; protein binding;
VPS33B	5	lysosomal membrane; lysosome; late endosome membrane; lysosome localization; protein binding;

Genes shared at least 2 KEGG pathways with LAMTOR1 (count: 0)

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Region: chr11:71808338..71814433 View in gBrowse