ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ARHGEF17
Symbol Alias	TEM4, KIAA0337, p164-RhoGEF
Approved Name	Rho guanine nucleotide exchange factor (GEF) 17
Name Alias	Rho-specific guanine-nucleotide exchange factor 164 kDa, "tumor endothelial marker 4"
Location	11q13.3
Position	chr11:73019663-73080425, +
External Links	HGNC: 21726 Entrez Gene: 9828 Ensembl: ENSG00000110237 UCSC: uc001otu.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 9)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051056	regulation of small GTPase mediated signal transduction	Biological Process		30
GO:0035023	regulation of Rho protein signal transduction	Biological Process		9
GO:0048011	nerve growth factor receptor signaling pathway	Biological Process		42
GO:0007264	small GTPase mediated signal transduction	Biological Process		58
GO:0030036	actin cytoskeleton organization	Biological Process	IDA[12071859]	21
GO:0005829	cytosol	Cellular Component		447
GO:0006915	apoptotic process	Biological Process		111
GO:0005085	guanyl-nucleotide exchange factor activity	Molecular Function	IDA[12071859]	17
GO:0005089	Rho guanyl-nucleotide exchange factor activity	Molecular Function		11

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with ARHGEF17 (count: 8)

Gene Symbol	Pathway Count	Pathway List
ARHGEF4	8	regulation of small GTPase mediated signal transduction; regulation of Rho protein signal transduction; nerve growth factor receptor signaling pathway; small GTPase mediated signal transduction; cytosol; apoptotic process; guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity;
FGD3	8	regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; small GTPase mediated signal transduction; actin cytoskeleton organization; cytosol; apoptotic process; guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity;
TIAM2	8	regulation of small GTPase mediated signal transduction; regulation of Rho protein signal transduction; nerve growth factor receptor signaling pathway; small GTPase mediated signal transduction; cytosol; apoptotic process; guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity;
TRIO	8	regulation of small GTPase mediated signal transduction; regulation of Rho protein signal transduction; nerve growth factor receptor signaling pathway; small GTPase mediated signal transduction; cytosol; apoptotic process; guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity;
ARHGEF12	7	regulation of small GTPase mediated signal transduction; regulation of Rho protein signal transduction; nerve growth factor receptor signaling pathway; small GTPase mediated signal transduction; cytosol; apoptotic process; Rho guanyl-nucleotide exchange factor activity;
ARHGEF2	7	regulation of small GTPase mediated signal transduction; regulation of Rho protein signal transduction; nerve growth factor receptor signaling pathway; small GTPase mediated signal transduction; cytosol; apoptotic process; Rho guanyl-nucleotide exchange factor activity;
MCF2L	7	regulation of small GTPase mediated signal transduction; regulation of Rho protein signal transduction; nerve growth factor receptor signaling pathway; small GTPase mediated signal transduction; cytosol; apoptotic process; Rho guanyl-nucleotide exchange factor activity;
NET1	7	regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; small GTPase mediated signal transduction; cytosol; apoptotic process; guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity;

Genes shared at least 2 KEGG pathways with ARHGEF17 (count: 0)

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Region: chr11:73019663..73080425 View in gBrowse