ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MCF2L
Symbol Alias	KIAA0362, DBS, OST, ARHGEF14
Approved Name	MCF.2 cell line derived transforming sequence-like
Location	13q34
Position	chr13:113548692-113754053, 1
External Links	HGNC: 14576 Entrez Gene: 23263 Ensembl: ENSG00000126217 UCSC: uc010tjr.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2010]_155	chr13:112336427-112835822 (NCBI Build 35 (hg17))	499396	13q34	Duplication	Maternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 12)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007266	Rho protein signal transduction	biological process	IEA	12
GO:0035023	regulation of Rho protein signal transduction	biological process	IEA	10
GO:0007264	small GTPase mediated signal transduction	biological process	TAS	65
GO:0048011	nerve growth factor receptor signaling pathway	biological process	TAS	51
GO:0005829	cytosol	cellular component	TAS	485
GO:0005545	1-phosphatidylinositol binding	molecular function	IEA	6
GO:0005886	plasma membrane	cellular component	IEA	839
GO:0051056	regulation of small GTPase mediated signal transduction	biological process	TAS	32
GO:0005089	Rho guanyl-nucleotide exchange factor activity	molecular function	IEA	12
GO:0006915	apoptotic process	biological process	TAS	127
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IEA	141
GO:0030027	lamellipodium	cellular component	IEA	29

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MCF2L (count: 14)

Gene Symbol	Pathway Count	Pathway List
TIAM2	8	regulation of Rho protein signal transduction; small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; cytosol; regulation of small GTPase mediated signal transduction; Rho guanyl-nucleotide exchange factor activity; apoptotic process; lamellipodium;
ARHGEF17	7	regulation of Rho protein signal transduction; small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; cytosol; regulation of small GTPase mediated signal transduction; Rho guanyl-nucleotide exchange factor activity; apoptotic process;
ARHGEF4	7	regulation of Rho protein signal transduction; small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; cytosol; regulation of small GTPase mediated signal transduction; Rho guanyl-nucleotide exchange factor activity; apoptotic process;
ARHGEF12	7	regulation of Rho protein signal transduction; small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; cytosol; regulation of small GTPase mediated signal transduction; Rho guanyl-nucleotide exchange factor activity; apoptotic process;
TRIO	7	regulation of Rho protein signal transduction; small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; cytosol; regulation of small GTPase mediated signal transduction; Rho guanyl-nucleotide exchange factor activity; apoptotic process;
ARHGEF2	7	regulation of Rho protein signal transduction; small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; cytosol; regulation of small GTPase mediated signal transduction; Rho guanyl-nucleotide exchange factor activity; apoptotic process;
FGD3	7	small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; cytosol; regulation of small GTPase mediated signal transduction; Rho guanyl-nucleotide exchange factor activity; apoptotic process; lamellipodium;
NET1	6	small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; cytosol; regulation of small GTPase mediated signal transduction; Rho guanyl-nucleotide exchange factor activity; apoptotic process;
RHOD	5	Rho protein signal transduction; small GTPase mediated signal transduction; cytosol; plasma membrane; regulation of small GTPase mediated signal transduction;
MAPK3	5	small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; cytosol; apoptotic process; positive regulation of transcription from RNA polymerase II promoter;
RHOT2	5	small GTPase mediated signal transduction; cytosol; plasma membrane; regulation of small GTPase mediated signal transduction; apoptotic process;
UBC	5	nerve growth factor receptor signaling pathway; cytosol; plasma membrane; apoptotic process; positive regulation of transcription from RNA polymerase II promoter;
UBB	5	nerve growth factor receptor signaling pathway; cytosol; plasma membrane; apoptotic process; positive regulation of transcription from RNA polymerase II promoter;
PIK3R1	5	nerve growth factor receptor signaling pathway; cytosol; 1-phosphatidylinositol binding; plasma membrane; positive regulation of transcription from RNA polymerase II promoter;

Genes shared at least 2 KEGG pathways with MCF2L (count: 0)

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Region: chr13:113548692..113754053 View in gBrowse