ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0000187
Name activation of MAPK activity
Type biological process
No. of Genes in ADHDgene  22
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 22)

Literature-origin genes (count: 8)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
DRD4 dopamine receptor D4 11p15.5 67(49/18/0) IDA[15755724]
MAP2K5 mitogen-activated protein kinase kinase 5 15q22.31 1(1/0/0) ISS
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 15q13.3 2(0/1/1) IDA[10771023]
GRM1 glutamate receptor, metabotropic 1 6q24 1(1/0/0) IEA
FGF10 fibroblast growth factor 10 5p13-p12 1(0/1/0) IDA[14975937]
MAP2K3 mitogen-activated protein kinase kinase 3 17q11.2 1(0/1/0) TAS
NTF3 neurotrophin 3 12p13 4(1/3/0) IDA
ITGA1 integrin, alpha 1 5q11.1 2(0/2/0) IEA

Genes from other sources Help (count: 14)

Approved Symbol Approved Name Source Evidence[PMID]
UBB ubiquitin B Mapped by significant region TAS
C5 complement component 5 Mapped by significant region TAS[7649993]
UBC ubiquitin C Mapped by CNV TAS
TLR4 toll-like receptor 4 Mapped by significant region ISS
LPAR1 lysophosphatidic acid receptor 1 Mapped by significant region IEA
MAP3K11 mitogen-activated protein kinase kinase kinase 11 Mapped by significant region IMP[15258589]
PLA2G1B phospholipase A2, group IB (pancreas) Mapped by PBA pathway ISS[15528384]
GHR growth hormone receptor Mapped by CNV; Mapped by significant region ISS
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit Mapped by significant region NAS[11546797]
C1QTNF2 C1q and tumor necrosis factor related protein 2 Mapped by significant region IEA
MAPK1 mitogen-activated protein kinase 1 Mapped by LD-proxy TAS
GNG3 guanine nucleotide binding protein (G protein), gamma 3 Mapped by significant region TAS[10075696]
PLCE1 phospholipase C, epsilon 1 Mapped by PBA pathway IDA[11022047]
MAPK3 mitogen-activated protein kinase 3 Mapped by CNV TAS