ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ADRA1D
Symbol Alias	ADRA1R, ADRA1A, ADRA1
Approved Name	adrenergic, alpha-1D-, receptor
Location	20p13
Position	chr20:4201278-4229721, -
External Links	HGNC: 280 Entrez Gene: 146 Ensembl: ENSG00000171873 UCSC: uc002wkr.2
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Hawi, Z., 2012	This gene did not show significant association with ADHD.	Non-significant

Gene related SNPs (count: 14)

Literature-origin SNPs (count: 11)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs6133098	Chr20:4217249(Fwd)	intron_variant	1(0/1/0)
rs6116268	Chr20:4211440(Fwd)	intron_variant	1(0/1/0)
rs3787442	Chr20:4225394(Fwd)	intron_variant	1(0/1/0)
rs4815670	Chr20:4216864(Fwd)	intron_variant	1(0/1/0)
rs3787441	Chr20:4205060(Fwd)	intron_variant	1(0/1/0)
rs6052456	Chr20:4225573(Fwd)	intron_variant	1(0/1/0)
rs1556832	Chr20:4215557(Fwd)	intron_variant	1(0/1/0)
rs8183794	Chr20:4210448(Fwd)	intron_variant	1(0/1/0)
rs8118409	Chr20:4216663(Fwd)	intron_variant	1(0/1/0)
rs6084670	Chr20:4222509(Fwd)	intron_variant	1(0/1/0)
rs709024	Chr20:4201984(Fwd)	3_prime_UTR_variant	1(0/1/0)

LD-proxies (count: 3)

rs_ID	Location	Functional Annotation
rs2236554	Chr20:4202041(Fwd)	3_prime_UTR_variant
rs2326478	Chr20:4208247(Fwd)	intron_variant
rs835880	Chr20:4208895(Fwd)	intron_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 12)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0008284	positive regulation of cell proliferation	Biological Process	TAS[10860850]	69
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	Biological Process	TAS[10820200]	13
GO:0007267	cell-cell signaling	Biological Process	TAS[1656955]	38
GO:0007275	multicellular organismal development	Biological Process	TAS[10820200]	71
GO:0008283	cell proliferation	Biological Process	TAS[10820200]	60
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process	TAS[1656955]	72
GO:0006259	DNA metabolic process	Biological Process	TAS[10969806]	4
GO:0005887	integral to plasma membrane	Cellular Component	TAS[7746284]	220
GO:0005886	plasma membrane	Cellular Component		772
GO:0004937	alpha1-adrenergic receptor activity	Molecular Function		3
GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure	Biological Process		3
GO:0001986	negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure	Biological Process		1

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04270	Vascular smooth muscle contraction	33	The vascular smooth muscle cell (VSMC) is a highly specializ...... The vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regulate the blood flow and pressure. More...
hsa04020	Calcium signaling pathway	63	Ca2+ that enters the cell from the outside is a principal so...... Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs). More...
hsa04970	Salivary secretion	22	Saliva has manifold functions in maintaining the integrity o...... Saliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for example. Salivary secretion occurs in response to stimulation by neurotransmitters released from autonomic nerve endings. There are two secretory pathways: protein exocytosis and fluid secretion. Sympathetic stimulation leads to the activation of adenylate cyclase and accumulation of intracellular cAMP. The elevation of cAMP causes the secretion of proteins such as amylase and mucin. In contrast, parasympathetic stimulation activates phospholipase C and causes the elevation of intracellular Ca2+, which leads to fluid secretion; that is, water and ion transport. Ca2+ also induces amylase secretion, but the amount is smaller than that induced by cAMP. More...

Genes shared at least 5 GO terms with ADRA1D (count: 4)

Gene Symbol	Pathway Count	Pathway List
ADRA1B	8	adenylate cyclase-modulating G-protein coupled receptor signaling pathway; cell-cell signaling; multicellular organismal development; cell proliferation; G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; alpha1-adrenergic receptor activity;
ADRA1A	6	cell-cell signaling; G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; alpha1-adrenergic receptor activity; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure;
CHRM1	5	positive regulation of cell proliferation; cell proliferation; G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane;
EDNRA	5	positive regulation of cell proliferation; cell proliferation; G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane;

Genes shared at least 2 KEGG pathways with ADRA1D (count: 45)

Gene Symbol	Pathway Count	Pathway List
ADRA1A	4	Neuroactive ligand-receptor interaction; Vascular smooth muscle contraction; Calcium signaling pathway; Salivary secretion;
ADRA1B	4	Neuroactive ligand-receptor interaction; Vascular smooth muscle contraction; Calcium signaling pathway; Salivary secretion;
ADORA2A	3	Neuroactive ligand-receptor interaction; Vascular smooth muscle contraction; Calcium signaling pathway;
ADRB1	3	Neuroactive ligand-receptor interaction; Calcium signaling pathway; Salivary secretion;
ADRB2	3	Neuroactive ligand-receptor interaction; Calcium signaling pathway; Salivary secretion;
ADRB3	3	Neuroactive ligand-receptor interaction; Calcium signaling pathway; Salivary secretion;
CHRM3	3	Neuroactive ligand-receptor interaction; Calcium signaling pathway; Salivary secretion;
EDNRA	3	Neuroactive ligand-receptor interaction; Vascular smooth muscle contraction; Calcium signaling pathway;
ADCY4	3	Vascular smooth muscle contraction; Calcium signaling pathway; Salivary secretion;
ITPR1	3	Vascular smooth muscle contraction; Calcium signaling pathway; Salivary secretion;
ITPR2	3	Vascular smooth muscle contraction; Calcium signaling pathway; Salivary secretion;
PLCB2	3	Vascular smooth muscle contraction; Calcium signaling pathway; Salivary secretion;
PLCB3	3	Vascular smooth muscle contraction; Calcium signaling pathway; Salivary secretion;
PRKCB	3	Vascular smooth muscle contraction; Calcium signaling pathway; Salivary secretion;
BDKRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKAR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKBR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRNA7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRIN2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2C	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR4	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR5A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
LTB4R2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
OXTR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
TACR3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CACNA1C	2	Vascular smooth muscle contraction; Calcium signaling pathway;
CACNA1D	2	Vascular smooth muscle contraction; Calcium signaling pathway;
CACNA1F	2	Vascular smooth muscle contraction; Calcium signaling pathway;
CACNA1S	2	Vascular smooth muscle contraction; Calcium signaling pathway;
GUCY1A2	2	Vascular smooth muscle contraction; Salivary secretion;
PRKG1	2	Vascular smooth muscle contraction; Salivary secretion;
ATP2B3	2	Calcium signaling pathway; Salivary secretion;
NOS1	2	Calcium signaling pathway; Salivary secretion;
RYR3	2	Calcium signaling pathway; Salivary secretion;

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Region: chr20:4201278..4229721 View in gBrowse