ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CAMK2D
Previous Symbol	CAMKD
Approved Name	calcium/calmodulin-dependent protein kinase II delta
Previous Name	"calcium/calmodulin-dependent protein kinase (CaM kinase) II delta"
Location	4q26
Position	chr4:114372188-114683083, -1
External Links	HGNC: 1462 Entrez Gene: 817 Ensembl: ENSG00000145349 UCSC: uc003ibi.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Lesch[2011]_11	chr4:114833251-115343086 (NCBI Build 35 (hg17))	509835	4q26	Duplication	Maternal (healthy)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 30)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 30)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0030315	T-tubule	cellular component	IEA	12
GO:0005886	plasma membrane	cellular component	TAS	839
GO:0060333	interferon-gamma-mediated signaling pathway	biological process	TAS	12
GO:0019221	cytokine-mediated signaling pathway	biological process	TAS	33
GO:0043194	axon initial segment	cellular component	IEA	3
GO:0007268	synaptic transmission	biological process	TAS	103
GO:0030666	endocytic vesicle membrane	cellular component	TAS	14
GO:0005524	ATP binding	molecular function	NAS	265
GO:0060341	regulation of cellular localization	biological process	IMP[17179159]	1
GO:0046777	protein autophosphorylation	biological process	IEA	26
GO:0006468	protein phosphorylation	biological process	IDA[17179159]; NAS	58
GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	biological process	TAS[19482609]	3
GO:0005654	nucleoplasm	cellular component	TAS	210
GO:0010613	positive regulation of cardiac muscle hypertrophy	biological process	IMP[17179159]	2
GO:0006816	calcium ion transport	biological process	IEA	32
GO:0033017	sarcoplasmic reticulum membrane	cellular component	IEA	9
GO:0060048	cardiac muscle contraction	biological process	IEA	9
GO:0001558	regulation of cell growth	biological process	NAS[9060999]	12
GO:0008016	regulation of heart contraction	biological process	TAS[17157285]	8
GO:0043025	neuronal cell body	cellular component	IEA	56
GO:0018105	peptidyl-serine phosphorylation	biological process	IEA	13
GO:0004683	calmodulin-dependent protein kinase activity	molecular function	IEA	2
GO:0014704	intercalated disc	cellular component	IEA	10
GO:0002028	regulation of sodium ion transport	biological process	IEA	4
GO:0005954	calcium- and calmodulin-dependent protein kinase complex	cellular component	TAS[11264466]	2
GO:0005829	cytosol	cellular component	TAS	485
GO:0031594	neuromuscular junction	cellular component	IEA	9
GO:0005516	calmodulin binding	molecular function	IEA	33
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	biological process	TAS[17157285]	4
GO:0000082	G1/S transition of mitotic cell cycle	biological process	IEA	27

Gene related KEGG pathways (count: 8)

ID	Name	No. of Genes in ADHDgene
hsa04720	Long-term potentiation	16
hsa04740	Olfactory transduction	170
hsa04916	Melanogenesis	18
hsa04912	GnRH signaling pathway	30
hsa05214	Glioma	8
hsa04310	Wnt signaling pathway	25
hsa04020	Calcium signaling pathway	66
hsa04012	ErbB signaling pathway	20

Genes shared at least 5 GO terms with CAMK2D (count: 18)

Gene Symbol	Pathway Count	Pathway List
PDPK1	7	plasma membrane; synaptic transmission; ATP binding; protein autophosphorylation; protein phosphorylation; nucleoplasm; cytosol;
UBB	6	plasma membrane; cytokine-mediated signaling pathway; endocytic vesicle membrane; nucleoplasm; cytosol; G1/S transition of mitotic cell cycle;
UBC	6	plasma membrane; cytokine-mediated signaling pathway; endocytic vesicle membrane; nucleoplasm; cytosol; G1/S transition of mitotic cell cycle;
PAK1	6	plasma membrane; ATP binding; protein autophosphorylation; protein phosphorylation; intercalated disc; cytosol;
GSK3B	6	plasma membrane; ATP binding; protein phosphorylation; neuronal cell body; peptidyl-serine phosphorylation; cytosol;
ILK	6	plasma membrane; ATP binding; protein phosphorylation; neuronal cell body; peptidyl-serine phosphorylation; cytosol;
RYR2	6	plasma membrane; calcium ion transport; sarcoplasmic reticulum membrane; cardiac muscle contraction; calmodulin binding; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;
RYR1	5	T-tubule; plasma membrane; calcium ion transport; sarcoplasmic reticulum membrane; calmodulin binding;
ADRBK1	5	plasma membrane; ATP binding; cardiac muscle contraction; peptidyl-serine phosphorylation; cytosol;
SYK	5	plasma membrane; ATP binding; protein autophosphorylation; protein phosphorylation; cytosol;
PRKD1	5	plasma membrane; ATP binding; protein autophosphorylation; peptidyl-serine phosphorylation; cytosol;
MYO10	5	plasma membrane; ATP binding; neuronal cell body; cytosol; calmodulin binding;
CACNA1C	5	plasma membrane; synaptic transmission; neuronal cell body; calmodulin binding; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;
IRF7	5	interferon-gamma-mediated signaling pathway; cytokine-mediated signaling pathway; protein phosphorylation; nucleoplasm; cytosol;
MAPK3	5	cytokine-mediated signaling pathway; ATP binding; protein phosphorylation; nucleoplasm; cytosol;
MAPK1	5	synaptic transmission; ATP binding; nucleoplasm; peptidyl-serine phosphorylation; cytosol;
PLK1	5	ATP binding; protein phosphorylation; nucleoplasm; peptidyl-serine phosphorylation; cytosol;
STK11	5	ATP binding; protein autophosphorylation; protein phosphorylation; regulation of cell growth; cytosol;

Genes shared at least 2 KEGG pathways with CAMK2D (count: 32)

Gene Symbol	Pathway Count	Pathway List
MAPK3	5	Long-term potentiation; Melanogenesis; GnRH signaling pathway; Glioma; ErbB signaling pathway;
ADCY3	5	Long-term potentiation; Olfactory transduction; Melanogenesis; GnRH signaling pathway; Calcium signaling pathway;
PLCB2	5	Long-term potentiation; Melanogenesis; GnRH signaling pathway; Wnt signaling pathway; Calcium signaling pathway;
MAPK1	5	Long-term potentiation; Melanogenesis; GnRH signaling pathway; Glioma; ErbB signaling pathway;
PLCB3	5	Long-term potentiation; Melanogenesis; GnRH signaling pathway; Wnt signaling pathway; Calcium signaling pathway;
ITPR2	3	Long-term potentiation; GnRH signaling pathway; Calcium signaling pathway;
CACNA1C	3	Long-term potentiation; GnRH signaling pathway; Calcium signaling pathway;
ITPR1	3	Long-term potentiation; GnRH signaling pathway; Calcium signaling pathway;
CREBBP	3	Long-term potentiation; Melanogenesis; Wnt signaling pathway;
PPP3R2	3	Long-term potentiation; Wnt signaling pathway; Calcium signaling pathway;
ADCY4	3	Melanogenesis; GnRH signaling pathway; Calcium signaling pathway;
GSK3B	3	Melanogenesis; Wnt signaling pathway; ErbB signaling pathway;
ADCY9	3	Melanogenesis; GnRH signaling pathway; Calcium signaling pathway;
ADCY2	3	Melanogenesis; GnRH signaling pathway; Calcium signaling pathway;
MAPK9	3	GnRH signaling pathway; Wnt signaling pathway; ErbB signaling pathway;
PLCG2	3	Glioma; Calcium signaling pathway; ErbB signaling pathway;
GRM1	2	Long-term potentiation; Calcium signaling pathway;
GRIN2A	2	Long-term potentiation; Calcium signaling pathway;
GRM5	2	Long-term potentiation; Calcium signaling pathway;
GNAL	2	Olfactory transduction; Calcium signaling pathway;
WNT10A	2	Melanogenesis; Wnt signaling pathway;
WNT11	2	Melanogenesis; Wnt signaling pathway;
WNT6	2	Melanogenesis; Wnt signaling pathway;
FZD4	2	Melanogenesis; Wnt signaling pathway;
CACNA1D	2	GnRH signaling pathway; Calcium signaling pathway;
CACNA1S	2	GnRH signaling pathway; Calcium signaling pathway;
CACNA1F	2	GnRH signaling pathway; Calcium signaling pathway;
PIK3R1	2	Glioma; ErbB signaling pathway;
PIK3CG	2	Glioma; ErbB signaling pathway;
SHC3	2	Glioma; ErbB signaling pathway;
CCND1	2	Glioma; Wnt signaling pathway;
ERBB2	2	Calcium signaling pathway; ErbB signaling pathway;

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Region: chr4:114372188..114683083 View in gBrowse