ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs12259062 dbSNP Ensembl
Location	Chr10:92610045(Fwd)
Variant Alleles	A/G
Ancestral Allele	G
Functional Annotation	intron_variant.
Consequence to Transcript	intron_variant(ENST00000336152; ENST00000371719; ENST00000277874; ENST00000371721)
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Ribases M, 2009(b)			Case-control test: lowest P-value=0.02 for genotype analysis...... Case-control test: lowest P-value=0.02 for genotype analysis, P-value=0.048 for allele analysis in adult combined ADHD. More...	no significance after correcting for multiple comparisons no significance after correcting for multiple comparisons	Significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
HTR7	5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)	10q21-q24	1(0/1/0)

Genes from other sources (count: 0)

SNPs in LD with rs12259062 (count: 27) View in gBrowse (chr10:92447675..92666683 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 1)

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs11186320	intron_variant	1(1/0/0)	0.873[CEU]; 1.0[CHB]; 1.0[JPT]

LD-proxies (count: 26)

rs_ID	Functional Annotation	r²[population]
rs4933618	intron_variant; nc_transcript_variant; upstream_gene_variant	0.881[CEU]; 0.87[CHB]; 0.821[JPT]; 1.0[YRI]
rs4522081	3_prime_UTR_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	0.881[CEU]; 0.954[CHB]; 0.86[JPT]
rs7913746		0.804[CEU]
rs7896973	intron_variant; nc_transcript_variant; upstream_gene_variant	0.881[CEU]; 0.954[CHB]; 1.0[YRI]
rs12254390	upstream_gene_variant	0.879[CEU]; 0.954[CHB]; 0.863[JPT]; 1.0[YRI]
rs10881844	intron_variant; nc_transcript_variant	0.873[CEU]; 0.904[CHB]; 1.0[YRI]
rs11599902	intron_variant	0.873[CEU]; 1.0[CHB]; 1.0[JPT]
rs7909232	intron_variant; nc_transcript_variant; upstream_gene_variant	0.873[CEU]; 0.953[CHB]; 0.86[JPT]; 1.0[YRI]
rs12246757	intron_variant; nc_transcript_variant; upstream_gene_variant	0.877[CEU]; 0.954[CHB]; 0.863[JPT]; 1.0[YRI]
rs11186351	intron_variant; nc_transcript_variant; upstream_gene_variant	0.88[CEU]; 0.953[CHB]; 1.0[YRI]
rs4520504	intron_variant	0.832[CEU]; 1.0[CHB]; 1.0[JPT]
rs2105411		0.804[CEU]
rs11597471	intron_variant	0.873[CEU]; 1.0[CHB]; 0.952[JPT]
rs7913864		0.832[CEU]
rs7083729		0.858[CEU]; 0.945[CHB]; 0.896[JPT]; 1.0[YRI]
rs7896481		0.804[CEU]
rs4568910	downstream_gene_variant; intron_variant; nc_transcript_variant	0.881[CEU]; 0.954[CHB]; 1.0[YRI]
rs7089472	downstream_gene_variant; intron_variant; nc_transcript_variant	0.873[CEU]; 0.953[CHB]; 1.0[YRI]
rs2000322		0.873[CEU]
rs7087400	intron_variant	0.836[CEU]; 1.0[CHB]; 1.0[JPT]
rs10881818		0.804[CEU]
rs10785972	intron_variant	0.843[CEU]; 1.0[CHB]; 1.0[JPT]
rs7101301	intron_variant; nc_transcript_variant; upstream_gene_variant	0.873[CEU]; 0.952[CHB]; 0.809[JPT]; 1.0[YRI]
rs12259401	intron_variant	1.0[CHB]; 1.0[JPT]
rs10881838	intron_variant	0.873[CEU]; 1.0[CHB]; 0.953[JPT]
rs7900048	downstream_gene_variant; intron_variant; nc_transcript_variant	0.873[CEU]; 0.908[CHB]; 0.857[JPT]; 1.0[YRI]