ADHDgene Database

Gene Report

Basic Info

Approved Symbol	MTNR1B
Approved Name	melatonin receptor 1B
Location	11q21-q22
Position	chr11:92702789-92718232, +
External Links	HGNC: 7464 Entrez Gene: 4544 Ensembl: ENSG00000134640 UCSC: uc001pdk.1
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by significant region

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Chaste P, 2011	Several damaging mutations were found in patients with ADHD, but no significant enrichment compared with the general population.	Trend

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 4)

Variant Name	Variant Type	No. of Studies (significant/non-significant/trend)
MTNR1B_G/A_R231H	point mutation	1 (0/0/1)
MTNR1B_G/A_G24E	point mutation	1 (0/0/1)
MTNR1B_C/T_R138C	point mutation	1 (0/0/1)
MTNR1B_A/G_K243R	point mutation	1 (0/0/1)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005886	plasma membrane	Cellular Component		772
GO:0004930	G-protein coupled receptor activity	Molecular Function	TAS[7568007]	236
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	Biological Process	TAS[7568007]	18
GO:0005887	integral to plasma membrane	Cellular Component	TAS[7568007]	220
GO:0007268	synaptic transmission	Biological Process	TAS[7568007]	96
GO:0008502	melatonin receptor activity	Molecular Function		2
GO:0042593	glucose homeostasis	Biological Process		18
GO:0050796	regulation of insulin secretion	Biological Process		22

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93

Genes shared at least 5 GO terms with MTNR1B (count: 1)

Gene Symbol	Pathway Count	Pathway List
HTR1E	5	plasma membrane; G-protein coupled receptor activity; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; integral to plasma membrane; synaptic transmission;

Genes shared at least 2 KEGG pathways with MTNR1B (count: 0)

View in gBrowse

Region: chr11:92702789..92718232 View in gBrowse