ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0050796
Name regulation of insulin secretion
Type biological process
No. of Genes in ADHDgene  25
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 25)

Literature-origin genes (count: 9)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
SNAP25 synaptosomal-associated protein, 25kDa 20p12-p11.2 21(16/5/0) TAS
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 6p12 1(1/0/0) IMP[19325541]
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 12p13.3 3(0/3/0) TAS
ADRA2C adrenoceptor alpha 2C 4p16.3 7(2/4/1) TAS
STX1A syntaxin 1A (brain) 7q11.2 3(2/1/0) TAS
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 17p13.1 2(0/2/0) TAS
CNR1 cannabinoid receptor 1 (brain) 6q14-q15 1(1/0/0) IEA
ADRA2A adrenoceptor alpha 2A 10q25.2 13(4/9/0) TAS
MTNR1B melatonin receptor 1B 11q21-q22 1(0/0/1) IMP

Genes from other sources Help (count: 16)

Approved Symbol Approved Name Source Evidence[PMID]
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit Mapped by PBA pathway TAS
CHRM3 cholinergic receptor, muscarinic 3 Mapped by CNV; Mapped by PBA pathway TAS
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) Mapped by LD-proxy TAS
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 Mapped by CNV TAS
SYT9 synaptotagmin IX Mapped by CNV IEA
SYT7 synaptotagmin VII Mapped by significant region IEA
RFX6 regulatory factor X, 6 Mapped by significant region IMP
SEC11C SEC11 homolog C (S. cerevisiae) Mapped by significant region TAS
CPT1A carnitine palmitoyltransferase 1A (liver) Mapped by CNV; Mapped by significant region IEA
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit Mapped by PBA pathway TAS
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit Mapped by significant region; Mapped by PBA pathway TAS
SSTR5 somatostatin receptor 5 Mapped by significant region IEA
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta Mapped by CNV TAS
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 Mapped by Literature SNP TAS
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) Mapped by significant region TAS
INS insulin Mapped by Literature SNP TAS