ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Other Variant Report

Basic Info
Name HTR1B_G861C
Type point mutation
Related Gene HTR1B
No. of Study 3 (significant: 2; non-significant 1; trend: 0)

Variant related studies (count: 3)
Reference Allele Change Risk Allele Statistical Values Author Comments Result of Statistical Analysis
Quist JF, 2003 G/C allelic TDT P-value=0.09, X2=2.91 in entire sampl...... allelic TDT P-value=0.09, X2=2.91 in entire sample; allelic TDT P-value=0.03, X2=4.80 for paternal transmission; allelic TDT P-value=0.49, X2=0.47 for maternal transmission More... revealed a trend towards preferential transmission of the 86...... revealed a trend towards preferential transmission of the 861G allele and exhibited significantly greater paternal transmission of the G allele to the affected child More... Significant
Li J, 2005 C/G allelic TDT P-value=0.413, McNemar X2=0.669 in AD...... allelic TDT P-value=0.413, McNemar X2=0.669 in ADHD; allelic TDT P-value=0.27, McNemar X2=1.217 in ADHD combined type; allelic TDT P-value=0.052, McNemar X2=3.766 in ADHD inattentive type More... no biased transmission was observed in families of ADHD prob...... no biased transmission was observed in families of ADHD probands; a preferential transmission of G allele was observed in ADHD-I trios, but not ADHD-C More... Non-significant
Hawi Z, 2002 G/C HHRR P-value=0.0065 (RR [95% CI]=1.24 [1.05-1.45], TDT P-val...... HHRR P-value=0.0065 (RR [95% CI]=1.24 [1.05-1.45], TDT P-value=0.014 (OR=1.44) in Total sample; HHRR P-value=0.0018 (RR [95% CI]=1.57 [1.15-2.16], TDT P-value=0.0037 (OR=2.2) in Ireland sample; HHRR P-value=0.08 (RR [95% CI]=1.26 [0.96-1.65], TDT P-value=0.14 (OR=1.52) in Wales/Manchester sample; HHRR P-value=0.33 (RR [95% CI]= 1.29 [0.73-2.27], TDT P-value=0.6 (OR=1.27) in England/Birmingham sample; HHRR P-value=0.44 (RR [95% CI]= 0.89 [0.67-1.19], TDT P-value=0.51 (OR=0.76) in England/London sample More... Significant preferential transmission of the allele 861G of ...... Significant preferential transmission of the allele 861G of the HTR1B was observed in the total sample More... Significant