ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Other Variant Report

Basic Info

Name	HTR1B_G861C
Type	point mutation
Related Gene	HTR1B
No. of Study	3 (significant: 2; non-significant 1; trend: 0)

Variant related studies (count: 3)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Li J, 2005	C/G		allelic TDT P-value=0.413, McNemar X²=0.669 in AD...... allelic TDT P-value=0.413, McNemar X²=0.669 in ADHD; allelic TDT P-value=0.27, McNemar X²=1.217 in ADHD combined type; allelic TDT P-value=0.052, McNemar X²=3.766 in ADHD inattentive type More...	no biased transmission was observed in families of ADHD prob...... no biased transmission was observed in families of ADHD probands; a preferential transmission of G allele was observed in ADHD-I trios, but not ADHD-C More...	Non-significant
Quist JF, 2003	G/C		allelic TDT P-value=0.09, X²=2.91 in entire sampl...... allelic TDT P-value=0.09, X²=2.91 in entire sample; allelic TDT P-value=0.03, X²=4.80 for paternal transmission; allelic TDT P-value=0.49, X²=0.47 for maternal transmission More...	revealed a trend towards preferential transmission of the 86...... revealed a trend towards preferential transmission of the 861G allele and exhibited significantly greater paternal transmission of the G allele to the affected child More...	Significant
Hawi Z, 2002	G/C		HHRR P-value=0.0065 (RR [95% CI]=1.24 [1.05-1.45], TDT P-val...... HHRR P-value=0.0065 (RR [95% CI]=1.24 [1.05-1.45], TDT P-value=0.014 (OR=1.44) in Total sample; HHRR P-value=0.0018 (RR [95% CI]=1.57 [1.15-2.16], TDT P-value=0.0037 (OR=2.2) in Ireland sample; HHRR P-value=0.08 (RR [95% CI]=1.26 [0.96-1.65], TDT P-value=0.14 (OR=1.52) in Wales/Manchester sample; HHRR P-value=0.33 (RR [95% CI]= 1.29 [0.73-2.27], TDT P-value=0.6 (OR=1.27) in England/Birmingham sample; HHRR P-value=0.44 (RR [95% CI]= 0.89 [0.67-1.19], TDT P-value=0.51 (OR=0.76) in England/London sample More...	Significant preferential transmission of the allele 861G of ...... Significant preferential transmission of the allele 861G of the HTR1B was observed in the total sample More...	Significant