ADHDgene Database

Gene Report

Basic Info

Approved Symbol	PTGER4
Symbol Alias	EP4
Approved Name	prostaglandin E receptor 4 (subtype EP4)
Location	5p13.1
Position	chr5:40679600-40693837, +
External Links	HGNC: 9596 Entrez Gene: 5734 Ensembl: ENSG00000171522 UCSC: uc003jlz.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
5p13	chr5:28900000-42500000	3 (1/1/1)

Gene related GO terms (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:2000420	negative regulation of eosinophil extravasation	Biological Process		1
GO:0070371	ERK1 and ERK2 cascade	Biological Process		7
GO:0071260	cellular response to mechanical stimulus	Biological Process		14
GO:0051492	regulation of stress fiber assembly	Biological Process		3
GO:0060348	bone development	Biological Process		2
GO:0050728	negative regulation of inflammatory response	Biological Process	IDA[16424369]	11
GO:0050729	positive regulation of inflammatory response	Biological Process		8
GO:0050715	positive regulation of cytokine secretion	Biological Process		8
GO:0050710	negative regulation of cytokine secretion	Biological Process		4
GO:0042093	T-helper cell differentiation	Biological Process		2
GO:0033624	negative regulation of integrin activation	Biological Process		1
GO:0032496	response to lipopolysaccharide	Biological Process		22
GO:0030278	regulation of ossification	Biological Process		1
GO:0016021	integral to membrane	Cellular Component	NAS[8163486]	845
GO:0009612	response to mechanical stimulus	Biological Process		9
GO:0007254	JNK cascade	Biological Process		11
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	Biological Process	IDA[8163486]	13
GO:0006955	immune response	Biological Process	IEP[8862514]	45
GO:0005886	plasma membrane	Cellular Component		772
GO:0005515	protein binding	Molecular Function	IPI[16424369]	910
GO:0004957	prostaglandin E receptor activity	Molecular Function	IDA[8163486]	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93

Genes shared at least 5 GO terms with PTGER4 (count: 1)

Gene Symbol	Pathway Count	Pathway List
TLR4	6	cellular response to mechanical stimulus; positive regulation of inflammatory response; response to lipopolysaccharide; immune response; plasma membrane; protein binding;

Genes shared at least 2 KEGG pathways with PTGER4 (count: 0)

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Region: chr5:40679600..40693837 View in gBrowse