ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	FLT4
Symbol Alias	VEGFR3, PCL
Approved Name	fms-related tyrosine kinase 4
Location	5q34-q35
Position	chr5:180028506-180076624, -
External Links	HGNC: 3767 Entrez Gene: 2324 Ensembl: ENSG00000037280 UCSC: uc003mlz.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_14	chr5:178157153-180497731 (NCBI36 / hg18)	2340579	5q35.3	dup

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 32)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 32)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005515	protein binding	Molecular Function		910
GO:0005524	ATP binding	Molecular Function		228
GO:0005576	extracellular region	Cellular Component		240
GO:0005634	nucleus	Cellular Component		770
GO:0005737	cytoplasm	Cellular Component		690
GO:0005886	plasma membrane	Cellular Component	IDA[7898938]	772
GO:0005887	integral to plasma membrane	Cellular Component		220
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process	TAS[10835628]	16
GO:0001934	positive regulation of protein phosphorylation	Biological Process	IMP[11532940]	22
GO:0001938	positive regulation of endothelial cell proliferation	Biological Process	IMP[11532940]	8
GO:0001944	vasculature development	Biological Process		3
GO:0001945	lymph vessel development	Biological Process		3
GO:0001946	lymphangiogenesis	Biological Process	IMP[19779139]	4
GO:0002040	sprouting angiogenesis	Biological Process		4
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Molecular Function	IMP[7898938]	5
GO:0005021	vascular endothelial growth factor-activated receptor activity	Molecular Function	IDA[9012504]; IMP[11532940]	1
GO:0019838	growth factor binding	Molecular Function	IPI[9435229]	8
GO:0019903	protein phosphatase binding	Molecular Function		12
GO:0035924	cellular response to vascular endothelial growth factor stimulus	Biological Process	IDA[9435229]; IMP[19779139]	3
GO:0043066	negative regulation of apoptotic process	Biological Process	IMP[11532940]	77
GO:0008284	positive regulation of cell proliferation	Biological Process	IGI[11574540]; IMP[19779139]	69
GO:0010575	positive regulation vascular endothelial growth factor production	Biological Process	IMP[19779139]	4
GO:0010595	positive regulation of endothelial cell migration	Biological Process	IMP[11532940]	7
GO:0018108	peptidyl-tyrosine phosphorylation	Biological Process	IDA[7898938]	3
GO:0048514	blood vessel morphogenesis	Biological Process		4
GO:0060312	regulation of blood vessel remodeling	Biological Process		1
GO:0070374	positive regulation of ERK1 and ERK2 cascade	Biological Process	IMP[11532940]	22
GO:0090037	positive regulation of protein kinase C signaling cascade	Biological Process	IMP[11532940]	6
GO:0043410	positive regulation of MAPK cascade	Biological Process	IMP[19779139]	17
GO:0046330	positive regulation of JNK cascade	Biological Process	IMP[16076871]	12
GO:0046777	protein autophosphorylation	Biological Process	IDA[7675451]	23
GO:0048010	vascular endothelial growth factor receptor signaling pathway	Biological Process	IDA[9012504]; IGI[11574540]; IMP[11532940]	6

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04510	Focal adhesion	40	Cell-matrix adhesions play essential roles in important biol...... Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling. More...
hsa04060	Cytokine-cytokine receptor interaction	38	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...

Genes shared at least 5 GO terms with FLT4 (count: 64)

Gene Symbol	Pathway Count	Pathway List
PRKD1	11	protein binding; ATP binding; nucleus; cytoplasm; plasma membrane; integral to plasma membrane; positive regulation of endothelial cell proliferation; cellular response to vascular endothelial growth factor stimulus; positive regulation of endothelial cell migration; protein autophosphorylation; vascular endothelial growth factor receptor signaling pathway;
VEGFA	11	protein binding; extracellular region; cytoplasm; positive regulation of protein phosphorylation; positive regulation of endothelial cell proliferation; cellular response to vascular endothelial growth factor stimulus; negative regulation of apoptotic process; positive regulation of cell proliferation; positive regulation of endothelial cell migration; positive regulation of protein kinase C signaling cascade; vascular endothelial growth factor receptor signaling pathway;
ERBB2	10	protein binding; ATP binding; nucleus; plasma membrane; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of protein phosphorylation; transmembrane receptor protein tyrosine kinase activity; growth factor binding; protein phosphatase binding; protein autophosphorylation;
GHR	7	protein binding; extracellular region; nucleus; plasma membrane; integral to plasma membrane; growth factor binding; protein phosphatase binding;
MUSK	7	protein binding; ATP binding; integral to plasma membrane; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of protein phosphorylation; transmembrane receptor protein tyrosine kinase activity; protein autophosphorylation;
SYK	7	protein binding; ATP binding; plasma membrane; lymph vessel development; peptidyl-tyrosine phosphorylation; blood vessel morphogenesis; protein autophosphorylation;
ADAM17	6	protein binding; cytoplasm; plasma membrane; integral to plasma membrane; positive regulation of protein phosphorylation; positive regulation of cell proliferation;
GSK3B	6	protein binding; ATP binding; nucleus; cytoplasm; plasma membrane; negative regulation of apoptotic process;
PYCARD	6	protein binding; extracellular region; nucleus; cytoplasm; positive regulation of ERK1 and ERK2 cascade; positive regulation of JNK cascade;
SNCA	6	protein binding; extracellular region; nucleus; cytoplasm; plasma membrane; negative regulation of apoptotic process;
TGFBR1	6	protein binding; ATP binding; plasma membrane; growth factor binding; negative regulation of apoptotic process; positive regulation of cell proliferation;
TLR4	6	protein binding; cytoplasm; plasma membrane; integral to plasma membrane; positive regulation of ERK1 and ERK2 cascade; positive regulation of JNK cascade;
VEGFB	6	protein binding; extracellular region; positive regulation of endothelial cell proliferation; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; vascular endothelial growth factor receptor signaling pathway;
NTRK2	6	ATP binding; integral to plasma membrane; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell proliferation; positive regulation of MAPK cascade; protein autophosphorylation;
CTGF	6	extracellular region; plasma membrane; positive regulation of protein phosphorylation; positive regulation of cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of JNK cascade;
FGF10	6	extracellular region; nucleus; plasma membrane; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; positive regulation of MAPK cascade;
FGF4	6	extracellular region; nucleus; positive regulation of protein phosphorylation; negative regulation of apoptotic process; positive regulation of cell proliferation; positive regulation of ERK1 and ERK2 cascade;
ADRA1A	6	nucleus; plasma membrane; integral to plasma membrane; positive regulation of ERK1 and ERK2 cascade; positive regulation of protein kinase C signaling cascade; positive regulation of MAPK cascade;
TBX1	6	nucleus; positive regulation of protein phosphorylation; lymph vessel development; positive regulation of cell proliferation; blood vessel morphogenesis; positive regulation of MAPK cascade;
EDNRA	6	plasma membrane; integral to plasma membrane; positive regulation of protein phosphorylation; negative regulation of apoptotic process; positive regulation of cell proliferation; positive regulation of ERK1 and ERK2 cascade;
ADRA2A	5	protein binding; cytoplasm; plasma membrane; integral to plasma membrane; positive regulation of cell proliferation;
ADRB1	5	protein binding; nucleus; cytoplasm; plasma membrane; integral to plasma membrane;
ADRB2	5	protein binding; nucleus; plasma membrane; integral to plasma membrane; positive regulation of MAPK cascade;
ADRB3	5	protein binding; nucleus; plasma membrane; integral to plasma membrane; positive regulation of MAPK cascade;
APC	5	protein binding; nucleus; cytoplasm; plasma membrane; negative regulation of apoptotic process;
ARRB1	5	protein binding; nucleus; cytoplasm; plasma membrane; positive regulation of ERK1 and ERK2 cascade;
ARRB2	5	protein binding; nucleus; cytoplasm; plasma membrane; positive regulation of ERK1 and ERK2 cascade;
BCAR1	5	protein binding; cytoplasm; plasma membrane; positive regulation of endothelial cell migration; vascular endothelial growth factor receptor signaling pathway;
BDKRB2	5	protein binding; plasma membrane; integral to plasma membrane; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptotic process;
CBL	5	protein binding; nucleus; cytoplasm; plasma membrane; negative regulation of apoptotic process;
CHD1L	5	protein binding; ATP binding; nucleus; cytoplasm; plasma membrane;
CRYAB	5	protein binding; nucleus; cytoplasm; plasma membrane; negative regulation of apoptotic process;
CTNND1	5	protein binding; nucleus; cytoplasm; plasma membrane; protein phosphatase binding;
EHD3	5	protein binding; ATP binding; nucleus; cytoplasm; plasma membrane;
FGF19	5	protein binding; extracellular region; positive regulation of cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of JNK cascade;
FLCN	5	protein binding; nucleus; cytoplasm; plasma membrane; positive regulation of protein phosphorylation;
FRK	5	protein binding; ATP binding; nucleus; cytoplasm; plasma membrane;
GAB2	5	protein binding; cytoplasm; plasma membrane; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell proliferation;
IGF2	5	protein binding; extracellular region; positive regulation of protein phosphorylation; positive regulation of cell proliferation; positive regulation of MAPK cascade;
ILK	5	protein binding; ATP binding; cytoplasm; plasma membrane; positive regulation of cell proliferation;
INS	5	protein binding; extracellular region; negative regulation of apoptotic process; positive regulation of cell proliferation; positive regulation of MAPK cascade;
MALT1	5	protein binding; nucleus; cytoplasm; plasma membrane; negative regulation of apoptotic process;
MAP3K11	5	protein binding; ATP binding; cytoplasm; positive regulation of JNK cascade; protein autophosphorylation;
MAPK1	5	protein binding; ATP binding; nucleus; cytoplasm; positive regulation of cell proliferation;
MAPK3	5	protein binding; ATP binding; nucleus; positive regulation of protein phosphorylation; positive regulation of ERK1 and ERK2 cascade;
MARK2	5	protein binding; ATP binding; nucleus; plasma membrane; protein autophosphorylation;
MC1R	5	protein binding; cytoplasm; plasma membrane; integral to plasma membrane; positive regulation of protein kinase C signaling cascade;
MIF	5	protein binding; extracellular region; cytoplasm; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade;
NEK6	5	protein binding; ATP binding; nucleus; cytoplasm; protein autophosphorylation;
PAK1	5	protein binding; ATP binding; cytoplasm; plasma membrane; protein autophosphorylation;
PIK3CG	5	protein binding; ATP binding; cytoplasm; plasma membrane; negative regulation of apoptotic process;
PRKAA1	5	protein binding; ATP binding; nucleus; negative regulation of apoptotic process; positive regulation of cell proliferation;
PRKCB	5	protein binding; ATP binding; nucleus; cytoplasm; plasma membrane;
RELA	5	protein binding; nucleus; cytoplasm; negative regulation of apoptotic process; positive regulation of cell proliferation;
ROR2	5	protein binding; ATP binding; integral to plasma membrane; transmembrane receptor protein tyrosine kinase signaling pathway; transmembrane receptor protein tyrosine kinase activity;
SEMA4D	5	protein binding; plasma membrane; integral to plasma membrane; positive regulation of protein phosphorylation; negative regulation of apoptotic process;
SIK2	5	protein binding; ATP binding; nucleus; cytoplasm; protein autophosphorylation;
SMG1	5	protein binding; ATP binding; nucleus; cytoplasm; protein autophosphorylation;
XRCC5	5	protein binding; ATP binding; nucleus; cytoplasm; negative regulation of apoptotic process;
YAP1	5	protein binding; nucleus; cytoplasm; negative regulation of apoptotic process; positive regulation of cell proliferation;
KARS	5	ATP binding; extracellular region; nucleus; cytoplasm; plasma membrane;
ROS1	5	ATP binding; plasma membrane; transmembrane receptor protein tyrosine kinase signaling pathway; transmembrane receptor protein tyrosine kinase activity; protein phosphatase binding;
IL6	5	extracellular region; negative regulation of apoptotic process; positive regulation of cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of MAPK cascade;
FOXC2	5	nucleus; lymphangiogenesis; negative regulation of apoptotic process; positive regulation of endothelial cell migration; vascular endothelial growth factor receptor signaling pathway;

Genes shared at least 2 KEGG pathways with FLT4 (count: 2)

Gene Symbol	Pathway Count	Pathway List
VEGFA	2	Focal adhesion; Cytokine-cytokine receptor interaction;
VEGFB	2	Focal adhesion; Cytokine-cytokine receptor interaction;

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Region: chr5:180028506..180076624 View in gBrowse