ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	S1PR3
Previous Symbol	EDG3
Symbol Alias	EDG-3
Approved Name	sphingosine-1-phosphate receptor 3
Previous Name	endothelial differentiation, sphingolipid G-protein-coupled receptor, 3
Name Alias	sphingosine-1-phosphate receptor 3
Location	9q22.1-q22.2
Position	chr9:91606362-91619925, +
External Links	HGNC: 3167 Entrez Gene: 1903 Ensembl: ENSG00000213694 UCSC: uc004aqe.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q22	chr9:90400000-102600000	3 (1/1/1)

Gene related GO terms (count: 13)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0038036	sphingosine-1-phosphate receptor activity	Molecular Function		1
GO:0009653	anatomical structure morphogenesis	Biological Process	TAS[10555146]	26
GO:0032651	regulation of interleukin-1 beta production	Biological Process		1
GO:0008284	positive regulation of cell proliferation	Biological Process	TAS[10617617]	69
GO:0008289	lipid binding	Molecular Function	TAS[9409733]	23
GO:0007204	elevation of cytosolic calcium ion concentration	Biological Process	TAS[9409733]	20
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	Biological Process		6
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process	TAS[10617617]	72
GO:0006954	inflammatory response	Biological Process		51
GO:0005887	integral to plasma membrane	Cellular Component	TAS[9409733]	220
GO:0005886	plasma membrane	Cellular Component		772
GO:0004930	G-protein coupled receptor activity	Molecular Function	TAS[10555146]	236
GO:0001816	cytokine production	Biological Process		5

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93

Genes shared at least 5 GO terms with S1PR3 (count: 9)

Gene Symbol	Pathway Count	Pathway List
C3AR1	6	elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; inflammatory response; integral to plasma membrane; plasma membrane; G-protein coupled receptor activity;
CASR	5	anatomical structure morphogenesis; G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; G-protein coupled receptor activity;
CXCR2	5	positive regulation of cell proliferation; elevation of cytosolic calcium ion concentration; inflammatory response; integral to plasma membrane; plasma membrane;
EDNRA	5	positive regulation of cell proliferation; elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane;
BDKRB2	5	elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; inflammatory response; integral to plasma membrane; plasma membrane;
CCR5	5	elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; inflammatory response; integral to plasma membrane; plasma membrane;
LPAR1	5	elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; G-protein coupled receptor activity;
OPRM1	5	elevation of cytosolic calcium ion concentration; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; G-protein coupled receptor activity;
PIK3CG	5	elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; inflammatory response; plasma membrane; cytokine production;

Genes shared at least 2 KEGG pathways with S1PR3 (count: 0)

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Region: chr9:91606362..91619925 View in gBrowse