ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CASR
Previous Symbol	HHC, HHC1
Symbol Alias	FHH, NSHPT, GPRC2A
Approved Name	calcium-sensing receptor
Previous Name	hypocalciuric hypercalcemia 1
Name Alias	severe neonatal hyperparathyroidism
Location	3q21.1
Position	chr3:121902530-122005344, +
External Links	HGNC: 1514 Entrez Gene: 846 Ensembl: ENSG00000036828 UCSC: uc003eev.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 13)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016298	lipase activity	Molecular Function		49

GO terms by database search (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005887	integral to plasma membrane	Cellular Component	TAS[7759551]	220
GO:0005886	plasma membrane	Cellular Component		772
GO:0005515	protein binding	Molecular Function		910
GO:0005513	detection of calcium ion	Biological Process	TAS[7759551]	4
GO:0004930	G-protein coupled receptor activity	Molecular Function		236
GO:0004435	phosphatidylinositol phospholipase C activity	Molecular Function	TAS[7874174]	20
GO:0001503	ossification	Biological Process	TAS[7874174]	9
GO:0070509	calcium ion import	Biological Process		6
GO:0009653	anatomical structure morphogenesis	Biological Process	TAS[7916660]	26
GO:0007635	chemosensory behavior	Biological Process	TAS[7759551]	2
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process	TAS[7759551]	72
GO:0006874	cellular calcium ion homeostasis	Biological Process	TAS[7874174]	16

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with CASR (count: 10)

Gene Symbol	Pathway Count	Pathway List
BDKRB2	6	integral to plasma membrane; plasma membrane; protein binding; phosphatidylinositol phospholipase C activity; lipase activity; G-protein coupled receptor signaling pathway;
C3AR1	6	integral to plasma membrane; plasma membrane; G-protein coupled receptor activity; phosphatidylinositol phospholipase C activity; lipase activity; G-protein coupled receptor signaling pathway;
CCR5	6	integral to plasma membrane; plasma membrane; protein binding; phosphatidylinositol phospholipase C activity; lipase activity; G-protein coupled receptor signaling pathway;
CHRM1	5	integral to plasma membrane; plasma membrane; phosphatidylinositol phospholipase C activity; lipase activity; G-protein coupled receptor signaling pathway;
CHRM3	5	integral to plasma membrane; plasma membrane; phosphatidylinositol phospholipase C activity; lipase activity; G-protein coupled receptor signaling pathway;
DRD3	5	integral to plasma membrane; plasma membrane; protein binding; G-protein coupled receptor signaling pathway; cellular calcium ion homeostasis;
EDNRA	5	integral to plasma membrane; plasma membrane; phosphatidylinositol phospholipase C activity; lipase activity; G-protein coupled receptor signaling pathway;
F2RL2	5	integral to plasma membrane; plasma membrane; protein binding; phosphatidylinositol phospholipase C activity; lipase activity;
LPAR1	5	integral to plasma membrane; plasma membrane; protein binding; G-protein coupled receptor activity; G-protein coupled receptor signaling pathway;
S1PR3	5	integral to plasma membrane; plasma membrane; G-protein coupled receptor activity; anatomical structure morphogenesis; G-protein coupled receptor signaling pathway;

Genes shared at least 2 KEGG pathways with CASR (count: 0)

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Region: chr3:121902530..122005344 View in gBrowse