ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Gene Report

Basic Info
Approved Symbol ADRA2C
Previous Symbol ADRA2L2, ADRA2RL2
Symbol Alias ADRARL2
Approved Name adrenergic, alpha-2C-, receptor
Location 4p16.3
Position chr4:3768075-3770253, +
External Links HGNC: 283
Entrez Gene: 152
Ensembl: ENSG00000184160
UCSC: uc003ghm.2
No. of Studies 7 (significant: 2; non-significant: 4; trend: 1)
Source Literature-origin; Mapped by literature SNP

Gene related studies (count: 7)
Reference Statistical Values/Author Comments Result of Statistical Analysis
Feng J, 2001 C444T was found to occur in ADHD patients in this mutational analysis Trend
De Luca V, 2004 (b) no preferential transmission of any allele of microsatellite polymorphism in ADRA2C Non-significant
Barr CL, 2001(c) there was no evidence for biased transmission of any of the alleles of the ADRA2C polymorphism Non-significant
Guan L, 2009 1 SNP in this gene achieved significance for ADHD and ADHD-C in single SNP association analysis. Significant
Brookes K, 2006 UNPHASED TDT P-value=0.496, global P-value=0.942, WHAP TDT P_sum P-value=0.972, no SNP with nominal P-value<0.05 located in this gene Non-significant
Hawi, Z., 2012 This gene did not show significant association with ADHD. Non-significant
Cho SC, 2008(a) ADRA2C(GT)n repeat polymorphism is involved in the etiology of ADHD Significant

Gene related SNPs (count: 2)

Literature-origin SNPs (count: 2)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 2)

Gene related regions (count: 0)

Gene related GO terms (count: 28)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 28)

Gene related KEGG pathways (count: 1)

Genes shared at least 5 GO terms with ADRA2C (count: 44)

Genes shared at least 2 KEGG pathways with ADRA2C (count: 0)

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Region: chr4:3768075..3770253 View in gBrowse
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