ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Gene Report

Basic Info
Approved Symbol ADRA2C
Previous Symbol ADRA2L2, ADRA2RL2
Symbol Alias ADRARL2
Approved Name adrenoceptor alpha 2C
Previous Name "adrenergic, alpha-2C-, receptor"
Location 4p16.3
Position chr4:3768075-3770251, 1
External Links HGNC: 283
Entrez Gene: 152
Ensembl: ENSG00000184160
UCSC: uc003ghm.3
No. of Studies 7 (significant: 2; non-significant: 4; trend: 1)
Source Literature-origin; Mapped by Literature SNP

Gene related studies (count: 7)
Reference Statistical Values/Author Comments Result of Statistical Analysis
Hawi, Z., 2012 This gene did not show significant association with ADHD. Non-significant
Cho SC, 2008(a) ADRA2C(GT)n repeat polymorphism is involved in the etiology of ADHD Significant
Guan L, 2009 1 SNP in this gene achieved significance for ADHD and ADHD-C in single SNP association analysis. Significant
Barr CL, 2001(c) there was no evidence for biased transmission of any of the alleles of the ADRA2C polymorphism Non-significant
Feng J, 2001 C444T was found to occur in ADHD patients in this mutational analysis Trend
Brookes K, 2006 UNPHASED TDT P-value=0.496, global P-value=0.942, WHAP TDT P_sum P-value=0.972, no SNP with nominal P-value<0.05 located in this gene Non-significant
De Luca V, 2004 (b) no preferential transmission of any allele of microsatellite polymorphism in ADRA2C Non-significant

Gene related SNPs (count: 2)

Literature-origin SNPs (count: 2)

LD-proxies (count: 0)


Gene related CNVs (count: 0)

Gene related other variant (count: 2)

Gene related regions (count: 0)

Gene related GO terms (count: 28)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 28)


Gene related KEGG pathways (count: 1)

Genes shared at least 5 GO terms with ADRA2C (count: 46)

Genes shared at least 2 KEGG pathways with ADRA2C (count: 0)

View in gBrowse

Region: chr4:3768075..3770251 View in gBrowse
View in gBrowse