ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ADRA2B
Previous Symbol	ADRA2L1, ADRA2RL1
Symbol Alias	ADRARL1
Approved Name	adrenergic, alpha-2B-, receptor
Location	2q11.1
Position	chr2:96778623-96781888, -
External Links	HGNC: 282 Entrez Gene: 151 Ensembl: ENSG00000222040 UCSC: uc002svi.2
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Hawi, Z., 2012	Although suggestive evidence of association (nominal p <= 0.05) with the genes SLC6A2, ADRA1A, ADRA1B and ADRA2B was observed, none remained significant after permutation adjustments. These findings provide evidence of a contribution of the noradrenaline system to the genetic aetiology of ADHD.	Significant

Gene related SNPs (count: 8)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs2312955	Chr2:96777168(Fwd)	downstream_gene_variant	1(1/0/0)

LD-proxies (count: 7)

rs_ID	Location	Functional Annotation
rs13019188	Chr2:96774199(Fwd)	downstream_gene_variant
rs4426564	Chr2:96780986(Fwd)	synonymous_variant
rs7604842	Chr2:96777340(Fwd)	downstream_gene_variant
rs10183151	Chr2:96774786(Fwd)	downstream_gene_variant
rs2229169	Chr2:96780716(Fwd)	synonymous_variant
rs4907299	Chr2:96780122(Fwd)	3_prime_UTR_variant
rs2692894	Chr2:96784934(Fwd)	downstream_gene_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 21)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0032148	activation of protein kinase B activity	Biological Process	IDA[17215105]	6
GO:0030168	platelet activation	Biological Process		38
GO:0035625	epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	Biological Process	IDA[17215105]	4
GO:0032811	negative regulation of epinephrine secretion	Biological Process	NAS[16531006]	3
GO:0045777	positive regulation of blood pressure	Biological Process		6
GO:0045666	positive regulation of neuron differentiation	Biological Process	IDA[17215105]	13
GO:0070474	positive regulation of uterine smooth muscle contraction	Biological Process		3
GO:0051379	epinephrine binding	Molecular Function	IDA[17215105]	5
GO:0071883	activation of MAPK activity by adrenergic receptor signaling pathway	Biological Process	IDA[17215105]	3
GO:0000165	MAPK cascade	Biological Process		10
GO:0001525	angiogenesis	Biological Process		35
GO:0003056	regulation of vascular smooth muscle contraction	Biological Process		2
GO:0004938	alpha2-adrenergic receptor activity	Molecular Function	IDA[17215105]	3
GO:0005515	protein binding	Molecular Function	IPI[16531006]	910
GO:0005886	plasma membrane	Cellular Component		772
GO:0005887	integral to plasma membrane	Cellular Component	TAS[2164221]	220
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process	TAS[2164221]	72
GO:0007267	cell-cell signaling	Biological Process	TAS[2164221]	38
GO:0007565	female pregnancy	Biological Process		14
GO:0007596	blood coagulation	Biological Process		83
GO:0010700	negative regulation of norepinephrine secretion	Biological Process	NAS[16531006]; TAS[19477270]	4

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93

Genes shared at least 5 GO terms with ADRA2B (count: 13)

Gene Symbol	Pathway Count	Pathway List
ADRA2C	16	activation of protein kinase B activity; platelet activation; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway; negative regulation of epinephrine secretion; positive regulation of neuron differentiation; epinephrine binding; activation of MAPK activity by adrenergic receptor signaling pathway; alpha2-adrenergic receptor activity; protein binding; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway; cell-cell signaling; female pregnancy; blood coagulation; negative regulation of norepinephrine secretion;
ADRA2A	14	activation of protein kinase B activity; platelet activation; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway; negative regulation of epinephrine secretion; epinephrine binding; activation of MAPK activity by adrenergic receptor signaling pathway; alpha2-adrenergic receptor activity; protein binding; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway; female pregnancy; blood coagulation; negative regulation of norepinephrine secretion;
PIK3CG	6	platelet activation; angiogenesis; protein binding; plasma membrane; G-protein coupled receptor signaling pathway; blood coagulation;
CCR5	6	MAPK cascade; protein binding; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway; cell-cell signaling;
INS	5	activation of protein kinase B activity; MAPK cascade; protein binding; G-protein coupled receptor signaling pathway; cell-cell signaling;
APOA1	5	platelet activation; protein binding; plasma membrane; G-protein coupled receptor signaling pathway; blood coagulation;
BCAR1	5	platelet activation; protein binding; plasma membrane; G-protein coupled receptor signaling pathway; blood coagulation;
F2RL2	5	platelet activation; protein binding; plasma membrane; integral to plasma membrane; blood coagulation;
GP1BB	5	platelet activation; protein binding; plasma membrane; integral to plasma membrane; blood coagulation;
SYK	5	platelet activation; angiogenesis; protein binding; plasma membrane; blood coagulation;
TRPC3	5	platelet activation; protein binding; plasma membrane; integral to plasma membrane; blood coagulation;
OXTR	5	positive regulation of blood pressure; positive regulation of uterine smooth muscle contraction; plasma membrane; integral to plasma membrane; female pregnancy;
ADORA2A	5	protein binding; plasma membrane; integral to plasma membrane; cell-cell signaling; blood coagulation;

Genes shared at least 2 KEGG pathways with ADRA2B (count: 0)

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Region: chr2:96778623..96781888 View in gBrowse