ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	INHA
Approved Name	inhibin, alpha
Location	2q33-qter
Position	chr2:220433884-220440435, +
External Links	HGNC: 6065 Entrez Gene: 3623 Ensembl: ENSG00000123999 UCSC: uc002vmk.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2q35	chr2:215300000-221500000	1 (1/0/0)

Gene related GO terms (count: 35)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 35)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045786	negative regulation of cell cycle	Biological Process	TAS[12456957]	9
GO:0045650	negative regulation of macrophage differentiation	Biological Process	TAS[12456957]	1
GO:0046882	negative regulation of follicle-stimulating hormone secretion	Biological Process	NAS[3267209]	1
GO:0046881	positive regulation of follicle-stimulating hormone secretion	Biological Process	TAS[12456957]	1
GO:0051726	regulation of cell cycle	Biological Process	IDA[9032295]	8
GO:0046982	protein heterodimerization activity	Molecular Function		68
GO:0042127	regulation of cell proliferation	Biological Process	IDA[9032295]	20
GO:0034711	inhibin binding	Molecular Function		1
GO:0042541	hemoglobin biosynthetic process	Biological Process	IDA[1310063]	1
GO:0042326	negative regulation of phosphorylation	Biological Process	TAS[12456957]	5
GO:0043512	inhibin A complex	Cellular Component	IDA[7890768]	1
GO:0043025	neuronal cell body	Cellular Component		51
GO:0045578	negative regulation of B cell differentiation	Biological Process	TAS[12456957]	2
GO:0045077	negative regulation of interferon-gamma biosynthetic process	Biological Process	TAS[12456957]	1
GO:0008083	growth factor activity	Molecular Function	TAS[12324653]	25
GO:0008584	male gonad development	Biological Process		7
GO:0007267	cell-cell signaling	Biological Process	TAS[12456957]	38
GO:0007399	nervous system development	Biological Process	NAS[10320815]	54
GO:0030218	erythrocyte differentiation	Biological Process	NAS[1310063]	4
GO:0034673	inhibin-betaglycan-ActRII complex	Cellular Component	IDA[10746731]	1
GO:0009605	response to external stimulus	Biological Process	TAS[10320815]	1
GO:0030154	cell differentiation	Biological Process	TAS[12456957]	51
GO:0005515	protein binding	Molecular Function	IPI[2575216,10746731]	910
GO:0005576	extracellular region	Cellular Component	TAS[12456957]	240
GO:0005125	cytokine activity	Molecular Function	TAS[12456957]	19
GO:0005179	hormone activity	Molecular Function	TAS[12456957]	7
GO:0007165	signal transduction	Biological Process	TAS[3267209]	171
GO:0007166	cell surface receptor signaling pathway	Biological Process	TAS[12456957]	35
GO:0006917	induction of apoptosis	Biological Process	IDA[8267637]	31
GO:0007050	cell cycle arrest	Biological Process	TAS[12456957]	25
GO:0001501	skeletal system development	Biological Process	TAS[10865214]	16
GO:0005102	receptor binding	Molecular Function	IPI[9032295]	61
GO:0001917	photoreceptor inner segment	Cellular Component		5
GO:0001750	photoreceptor outer segment	Cellular Component		8
GO:0001541	ovarian follicle development	Biological Process	NAS[9166111]	4

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with INHA (count: 14)

Gene Symbol	Pathway Count	Pathway List
CLCF1	7	protein heterodimerization activity; growth factor activity; protein binding; extracellular region; cytokine activity; cell surface receptor signaling pathway; receptor binding;
VEGFA	7	protein heterodimerization activity; growth factor activity; nervous system development; protein binding; extracellular region; cytokine activity; ovarian follicle development;
NTF3	6	growth factor activity; cell-cell signaling; nervous system development; extracellular region; signal transduction; receptor binding;
PTPRK	5	negative regulation of cell cycle; neuronal cell body; protein binding; signal transduction; photoreceptor outer segment;
ERBB2	5	protein heterodimerization activity; nervous system development; protein binding; signal transduction; cell surface receptor signaling pathway;
IL12B	5	protein heterodimerization activity; growth factor activity; protein binding; cytokine activity; cell cycle arrest;
TXN	5	neuronal cell body; cell-cell signaling; protein binding; extracellular region; signal transduction;
FGF3	5	growth factor activity; cell-cell signaling; protein binding; extracellular region; signal transduction;
FGF9	5	growth factor activity; male gonad development; cell-cell signaling; extracellular region; signal transduction;
GDNF	5	growth factor activity; nervous system development; extracellular region; signal transduction; receptor binding;
IGF2	5	growth factor activity; protein binding; extracellular region; hormone activity; skeletal system development;
TNFSF8	5	cell-cell signaling; cytokine activity; signal transduction; induction of apoptosis; receptor binding;
MIF	5	protein binding; extracellular region; cytokine activity; cell surface receptor signaling pathway; receptor binding;
TGFBR1	5	protein binding; signal transduction; induction of apoptosis; cell cycle arrest; skeletal system development;

Genes shared at least 2 KEGG pathways with INHA (count: 0)

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Region: chr2:220433884..220440435 View in gBrowse