ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CLCF1
Symbol Alias	NNT1, BSF3, CLC, NR6, CISS2
Approved Name	cardiotrophin-like cytokine factor 1
Previous Name	CRLF1 associated cytokine-like factor 1
Name Alias	B-cell stimulating factor 3, "cold-induced sweating syndrome 2"
Location	11q13.3
Position	chr11:67131639-67141648, -
External Links	HGNC: 17412 Entrez Gene: 23529 Ensembl: ENSG00000175505 UCSC: uc001okq.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 21)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0043066	negative regulation of apoptotic process	Biological Process	TAS[14632778]	77
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein	Biological Process	IDA[11285233]; TAS[14632778]	7
GO:0046982	protein heterodimerization activity	Molecular Function	IDA[10966616]	68
GO:0043524	negative regulation of neuron apoptotic process	Biological Process	IDA[11285233]	19
GO:0019221	cytokine-mediated signaling pathway	Biological Process	NAS[10500198]	28
GO:0008284	positive regulation of cell proliferation	Biological Process	IDA[11285233]	69
GO:0030890	positive regulation of B cell proliferation	Biological Process		4
GO:0030183	B cell differentiation	Biological Process		8
GO:0007166	cell surface receptor signaling pathway	Biological Process		35
GO:0005576	extracellular region	Cellular Component	IDA[10966616]; NAS[10448081]	240
GO:0008083	growth factor activity	Molecular Function	TAS[14632778]	25
GO:0007259	JAK-STAT cascade	Biological Process		2
GO:0005125	cytokine activity	Molecular Function	IDA[10966616]; NAS[10500198]	19
GO:0005102	receptor binding	Molecular Function	IPI[15272019]	61
GO:0005515	protein binding	Molecular Function	IPI[10966616]	910
GO:0005127	ciliary neurotrophic factor receptor binding	Molecular Function	IDA[11285233,10966616]	3
GO:0002639	positive regulation of immunoglobulin production	Biological Process		3
GO:0097058	CRLF-CLCF1 complex	Cellular Component	IDA[10966616]	2
GO:0097059	CNTFR-CLCF1 complex	Cellular Component	IDA[11285233]	2
GO:0048295	positive regulation of isotype switching to IgE isotypes	Biological Process		1
GO:0048711	positive regulation of astrocyte differentiation	Biological Process		4

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04060	Cytokine-cytokine receptor interaction	38	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...
hsa04630	Jak-STAT signaling pathway	22	The Janus kinase/signal transducers and activators of transc...... The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors. More...

Genes shared at least 5 GO terms with CLCF1 (count: 11)

Gene Symbol	Pathway Count	Pathway List
IL6	7	negative regulation of apoptotic process; positive regulation of tyrosine phosphorylation of Stat3 protein; cytokine-mediated signaling pathway; positive regulation of cell proliferation; extracellular region; growth factor activity; cytokine activity;
MIF	7	negative regulation of apoptotic process; positive regulation of B cell proliferation; cell surface receptor signaling pathway; extracellular region; cytokine activity; receptor binding; protein binding;
VEGFA	7	negative regulation of apoptotic process; protein heterodimerization activity; positive regulation of cell proliferation; extracellular region; growth factor activity; cytokine activity; protein binding;
INHA	7	protein heterodimerization activity; cell surface receptor signaling pathway; extracellular region; growth factor activity; cytokine activity; receptor binding; protein binding;
VEGFB	6	negative regulation of apoptotic process; protein heterodimerization activity; negative regulation of neuron apoptotic process; extracellular region; growth factor activity; protein binding;
CNTF	6	positive regulation of tyrosine phosphorylation of Stat3 protein; negative regulation of neuron apoptotic process; positive regulation of cell proliferation; growth factor activity; ciliary neurotrophic factor receptor binding; CRLF-CLCF1 complex;
GDNF	5	negative regulation of apoptotic process; negative regulation of neuron apoptotic process; extracellular region; growth factor activity; receptor binding;
IL12B	5	positive regulation of tyrosine phosphorylation of Stat3 protein; protein heterodimerization activity; growth factor activity; cytokine activity; protein binding;
NTF3	5	negative regulation of neuron apoptotic process; positive regulation of cell proliferation; extracellular region; growth factor activity; receptor binding;
EREG	5	cytokine-mediated signaling pathway; positive regulation of cell proliferation; extracellular region; growth factor activity; protein binding;
LIFR	5	cytokine-mediated signaling pathway; positive regulation of cell proliferation; cell surface receptor signaling pathway; extracellular region; ciliary neurotrophic factor receptor binding;

Genes shared at least 2 KEGG pathways with CLCF1 (count: 16)

Gene Symbol	Pathway Count	Pathway List
CNTF	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
CNTFR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
CTF1	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
GHR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IFNGR1	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL10RA	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL11RA	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL12B	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL20RA	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL22RA2	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL5RA	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL6	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL7R	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
LIFR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
OSMR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
PRLR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;

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Region: chr11:67131639..67141648 View in gBrowse