Gene Report
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Basic Info
Approved Symbol |
PRLR
|
Approved Name |
prolactin receptor |
Location |
5p14-p13 |
Position |
chr5:35048861-35230794, - |
External Links |
HGNC: 9446
Entrez Gene: 5618
Ensembl: ENSG00000113494
UCSC: uc003jjm.2
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by significant region |
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Gene related studies (count: 0)
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Gene related SNPs (count: 0)
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Gene related CNVs (count: 0)
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Gene related other variant (count: 0)
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Gene related regions (count: 1)
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Gene related GO terms (count: 20)
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Gene related KEGG pathways (count: 3)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa04080 |
Neuroactive ligand-receptor interaction |
93 |
|
hsa04060 |
Cytokine-cytokine receptor interaction |
38 |
Cytokines are soluble extracellular proteins or glycoprotein......
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
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|
hsa04630 |
Jak-STAT signaling pathway |
22 |
The Janus kinase/signal transducers and activators of transc......
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
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|
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Genes shared at least 5 GO terms with PRLR (count: 4)
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Genes shared at least 2 KEGG pathways with PRLR (count: 16)
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