ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PRLR
Approved Name	prolactin receptor
Location	5p14-p13
Position	chr5:35048861-35230794, -
External Links	HGNC: 9446 Entrez Gene: 5618 Ensembl: ENSG00000113494 UCSC: uc003jjm.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
5p13	chr5:28900000-42500000	3 (1/1/1)

Gene related GO terms (count: 20)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006694	steroid biosynthetic process	Biological Process	NAS[10585417]	4
GO:0007166	cell surface receptor signaling pathway	Biological Process	NAS[10585417]	35
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	Biological Process	IDA[10585417]	3
GO:0007566	embryo implantation	Biological Process	TAS[9009200]	3
GO:0007595	lactation	Biological Process	NAS[10585417]	7
GO:0009986	cell surface	Cellular Component	IDA[10585417]	70
GO:0016021	integral to membrane	Cellular Component		845
GO:0017046	peptide hormone binding	Molecular Function	IPI[7984244]	5
GO:0031904	endosome lumen	Cellular Component		2
GO:0038161	prolactin signaling pathway	Biological Process	NAS[10585417]; TAS[2558309]	1
GO:0042110	T cell activation	Biological Process	NAS[10585417]	8
GO:0042803	protein homodimerization activity	Molecular Function	NAS[10585417]	113
GO:0042977	activation of JAK2 kinase activity	Biological Process	NAS[10585417]	2
GO:0042978	ornithine decarboxylase activator activity	Molecular Function	NAS[10585417]	1
GO:0043066	negative regulation of apoptotic process	Biological Process	NAS[10585417]	77
GO:0046872	metal ion binding	Molecular Function		170
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway	Biological Process		5
GO:0005886	plasma membrane	Cellular Component		772
GO:0005576	extracellular region	Cellular Component		240
GO:0004925	prolactin receptor activity	Molecular Function	NAS[10585417]	1

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04060	Cytokine-cytokine receptor interaction	38	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...
hsa04630	Jak-STAT signaling pathway	22	The Janus kinase/signal transducers and activators of transc...... The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors. More...

Genes shared at least 5 GO terms with PRLR (count: 4)

Gene Symbol	Pathway Count	Pathway List
GHR	8	cell surface; integral to membrane; peptide hormone binding; protein homodimerization activity; activation of JAK2 kinase activity; JAK-STAT cascade involved in growth hormone signaling pathway; plasma membrane; extracellular region;
VEGFA	5	lactation; cell surface; protein homodimerization activity; negative regulation of apoptotic process; extracellular region;
CRYAB	5	cell surface; protein homodimerization activity; negative regulation of apoptotic process; metal ion binding; plasma membrane;
ENPP1	5	cell surface; integral to membrane; protein homodimerization activity; metal ion binding; plasma membrane;

Genes shared at least 2 KEGG pathways with PRLR (count: 16)

Gene Symbol	Pathway Count	Pathway List
GHR	3	Neuroactive ligand-receptor interaction; Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
CLCF1	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
CNTF	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
CNTFR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
CTF1	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IFNGR1	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL10RA	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL11RA	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL12B	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL20RA	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL22RA2	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL5RA	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL6	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL7R	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
LIFR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
OSMR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;

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Region: chr5:35048861..35230794 View in gBrowse