ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

KEGG Pathway Report

Basic Info

ID	hsa04060
Name	Cytokine-cytokine receptor interaction
Description	Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
No. of Genes in ADHDgene	38
Source	Pathway by Database Search

Pathway related genes in ADHDgene (count: 38)

Literature-origin genes (count: 5)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
CNTF	ciliary neurotrophic factor	11q12	1(1/0/0)
IL20RA	interleukin 20 receptor, alpha	6q23.3	1(0/0/1)
BMPR1B	bone morphogenetic protein receptor, type IB	4q23-q24	1(0/0/1)
CNTFR	ciliary neurotrophic factor receptor	9p13	1(1/0/0)
VEGFA	vascular endothelial growth factor A	6p12	1(0/1/0)

Genes from other sources (count: 33)

Approved Symbol	Approved Name	Location	Source
IL7R	interleukin 7 receptor	5p13	Mapped by significant region
PRLR	prolactin receptor	5p14-p13	Mapped by significant region
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	5q31.1-q33.1	Mapped by significant region
IL10RA	interleukin 10 receptor, alpha	11q23	Mapped by significant region
CCR5	chemokine (C-C motif) receptor 5	3p21	Mapped by PBA pathway
IL18	interleukin 18 (interferon-gamma-inducing factor)	11q22.2-q22.3	Mapped by significant region
IL6	interleukin 6 (interferon, beta 2)	7p21-p15	Mapped by significant region
IL22RA2	interleukin 22 receptor, alpha 2	6q24.1-q24.2	Mapped by significant region
RELT	RELT tumor necrosis factor receptor	11q13.2	Mapped by significant region
CTF1	cardiotrophin 1	16p11.2	Mapped by CNV
GHR	growth hormone receptor	5p14-p12	Mapped by CNV; Mapped by significant region
IFNGR1	interferon gamma receptor 1	6q23-q24	Mapped by significant region
LIFR	leukemia inhibitory factor receptor alpha	5p13-p12	Mapped by significant region
CLCF1	cardiotrophin-like cytokine factor 1	11q13.3	Mapped by significant region
TGFBR1	transforming growth factor, beta receptor 1	9q22	Mapped by significant region
VEGFB	vascular endothelial growth factor B	11q13	Mapped by significant region
CXCR2	chemokine (C-X-C motif) receptor 2	2q35	Mapped by significant region
CXCR1	chemokine (C-X-C motif) receptor 1	2q35	Mapped by significant region
CXCR5	chemokine (C-X-C motif) receptor 5	11q23.3	Mapped by significant region
TNFSF18	tumor necrosis factor (ligand) superfamily, member 18	1q23	Mapped by significant region
TNFRSF11A	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	18q22.1	Mapped by CNV
TNFSF15	tumor necrosis factor (ligand) superfamily, member 15	9q32	Mapped by significant region
TNFRSF13B	tumor necrosis factor receptor superfamily, member 13B	17p11.2	Mapped by significant region
EDA2R	ectodysplasin A2 receptor	Xq11.1	Mapped by CNV
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	9q33	Mapped by significant region
TNFSF4	tumor necrosis factor (ligand) superfamily, member 4	1q25	Mapped by significant region
CCL27	chemokine (C-C motif) ligand 27	9p13	Mapped by LD-proxy
CCL19	chemokine (C-C motif) ligand 19	9p13	Mapped by LD-proxy
OSMR	oncostatin M receptor	5p13.2	Mapped by significant region
IL5RA	interleukin 5 receptor, alpha	3p26-p24	Mapped by CNV
CXCL12	chemokine (C-X-C motif) ligand 12	10q11.1	Mapped by PBA pathway
IL11RA	interleukin 11 receptor, alpha	9p13	Mapped by LD-proxy
FLT4	fms-related tyrosine kinase 4	5q34-q35	Mapped by CNV