ADHDgene Database

Gene Report

Basic Info

Approved Symbol	LIFR
Symbol Alias	CD118
Approved Name	leukemia inhibitory factor receptor alpha
Previous Name	"leukemia inhibitory factor receptor"
Location	5p13-p12
Position	chr5:38475065-38608456, -1
External Links	HGNC: 6597 Entrez Gene: 3977 Ensembl: ENSG00000113594 UCSC: uc003jli.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
5p	chr5:0-48400000	1 (1/0/0)
5p13	chr5:28900000-42500000	3 (1/1/1)

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0008284	positive regulation of cell proliferation	biological process	IDA[8999038]	75
GO:0038165	oncostatin-M-mediated signaling pathway	biological process	IDA[8999038]	2
GO:0005127	ciliary neurotrophic factor receptor binding	molecular function	IPI[12707266]	3
GO:0019221	cytokine-mediated signaling pathway	biological process	IDA[7957045]	33
GO:0007166	cell surface receptor signaling pathway	biological process	TAS[1915266]	36
GO:0005887	integral to plasma membrane	cellular component	TAS[1915266]	236
GO:0005576	extracellular region	cellular component	IEA	267
GO:0048861	leukemia inhibitory factor signaling pathway	biological process	IDA[12643274]	2
GO:0070120	ciliary neurotrophic factor-mediated signaling pathway	biological process	IDA[12643274]	3
GO:0034097	response to cytokine stimulus	biological process	IDA[8999038]	11
GO:0004923	leukemia inhibitory factor receptor activity	molecular function	IDA[7957045]; IDA[12643274]	1
GO:0004897	ciliary neurotrophic factor receptor activity	molecular function	IDA[12643274]	2
GO:0004924	oncostatin-M receptor activity	molecular function	IDA[8999038]	2
GO:0019838	growth factor binding	molecular function	IPI[8999038]	10

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04630	Jak-STAT signaling pathway	25
hsa04060	Cytokine-cytokine receptor interaction	39

Genes shared at least 5 GO terms with LIFR (count: 2)

Gene Symbol	Pathway Count	Pathway List
OSMR	6	positive regulation of cell proliferation; oncostatin-M-mediated signaling pathway; cell surface receptor signaling pathway; response to cytokine stimulus; oncostatin-M receptor activity; growth factor binding;
CLCF1	5	positive regulation of cell proliferation; ciliary neurotrophic factor receptor binding; cytokine-mediated signaling pathway; cell surface receptor signaling pathway; extracellular region;

Genes shared at least 2 KEGG pathways with LIFR (count: 16)

Gene Symbol	Pathway Count	Pathway List
IL5RA	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
OSMR	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
IL7R	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
CNTF	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
IL12B	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
GHR	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
IFNGR1	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
IL22RA2	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
IL10RA	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
IL11RA	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
CNTFR	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
CTF1	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
PRLR	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
IL6	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
CLCF1	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;
IL20RA	2	Jak-STAT signaling pathway; Cytokine-cytokine receptor interaction;

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Region: chr5:38475065..38608456 View in gBrowse