ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	LIFR
Symbol Alias	CD118
Approved Name	leukemia inhibitory factor receptor alpha
Previous Name	leukemia inhibitory factor receptor
Location	5p13-p12
Position	chr5:38475065-38608456, -
External Links	HGNC: 6597 Entrez Gene: 3977 Ensembl: ENSG00000113594 UCSC: uc003jli.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
5p13	chr5:28900000-42500000	3 (1/1/1)

Gene related GO terms (count: 14)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004897	ciliary neurotrophic factor receptor activity	Molecular Function	IDA[12643274]	2
GO:0004923	leukemia inhibitory factor receptor activity	Molecular Function	IDA[7957045,12643274]	1
GO:0004924	oncostatin-M receptor activity	Molecular Function	IDA[8999038]	2
GO:0005576	extracellular region	Cellular Component		240
GO:0005127	ciliary neurotrophic factor receptor binding	Molecular Function	IPI[12707266]	3
GO:0007166	cell surface receptor signaling pathway	Biological Process	TAS[1915266]	35
GO:0005887	integral to plasma membrane	Cellular Component	TAS[1915266]	220
GO:0019221	cytokine-mediated signaling pathway	Biological Process	IDA[7957045]	28
GO:0008284	positive regulation of cell proliferation	Biological Process	IDA[8999038]	69
GO:0034097	response to cytokine stimulus	Biological Process	IDA[8999038]	9
GO:0019838	growth factor binding	Molecular Function	IPI[8999038]	8
GO:0048861	leukemia inhibitory factor signaling pathway	Biological Process	IDA[12643274]	2
GO:0038165	oncostatin-M-mediated signaling pathway	Biological Process	IDA[8999038]	2
GO:0070120	ciliary neurotrophic factor-mediated signaling pathway	Biological Process	IDA[12643274]	3

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04060	Cytokine-cytokine receptor interaction	38	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...
hsa04630	Jak-STAT signaling pathway	22	The Janus kinase/signal transducers and activators of transc...... The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors. More...

Genes shared at least 5 GO terms with LIFR (count: 2)

Gene Symbol	Pathway Count	Pathway List
OSMR	6	oncostatin-M receptor activity; cell surface receptor signaling pathway; positive regulation of cell proliferation; response to cytokine stimulus; growth factor binding; oncostatin-M-mediated signaling pathway;
CLCF1	5	extracellular region; ciliary neurotrophic factor receptor binding; cell surface receptor signaling pathway; cytokine-mediated signaling pathway; positive regulation of cell proliferation;

Genes shared at least 2 KEGG pathways with LIFR (count: 16)

Gene Symbol	Pathway Count	Pathway List
CLCF1	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
CNTF	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
CNTFR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
CTF1	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
GHR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IFNGR1	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL10RA	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL11RA	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL12B	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL20RA	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL22RA2	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL5RA	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL6	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL7R	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
OSMR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
PRLR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;

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Region: chr5:38475065..38608456 View in gBrowse